Searchable abstracts of presentations at key conferences in endocrinology

ea0029p1734 | Thyroid (non-cancer) | ICEECE2012

The influence of chronic stimulation of thyrotropin on nodular thyroid goiter

Medenica S. , Trbojevic B. , Ciric J. , Beleslin B. , Stojkovic M.

Introduction: Nodular goiter is clinically recognizable restricted structure changes of the thyroid gland. FNA is the first line diagnostic test for an enlarged thyroid gland. TSH is known as a thyroid growth factor, but the pathogenic role of this hormone in thyroid oncogenesis is unclear.Objective: The aim of this study is to analyze the relationship between elevated serum TSH concentrations and thyroid malignancies in patients with nodular thyroid goi...

ea0022p48 | Adrenal | ECE2010

Combined primary aldosteronism and preclinical Cushing's syndrome due to a large adrenocortical adenoma

Ciric Jasmina , Beleslin Biljana , Stojkovic Mirjana , Trbojevic Bozo , Zarkovic Milos

The rarest causes of primary aldosteronism are aldosterone producing carcinoma, ectopic aldosterone secretion and familial aldosteronism. There are also few cases reported of aldosterone and cortisol tumor cosecretion. We present a 38-year-old woman admitted to our hospital because of resistant hypertension, large adrenal tumor and hypokalemia. At age 32 hypertension was diagnosed, but routine laboratory and abdominal ultrasound examination were normal. Few months before admis...

ea0032p290 | Clinical case reports - Thyroid / Others | ECE2013

Neurogenic hypertension as a case report

Nisic Tanja , Stojkovic Mira , Stojanovic Milos , Ciric Jasmina , Beleslin Biljana , Lalic Tiana , Zarkovic Milos , Trbojevic Bozo

Introduction: Neurogenic hypertension is associated with unilateral neurovascular compression of the brainstem and cranial nerves V, IX-X, VII, VIII. Causes may include nerve injury, vascular compression, tumors. Symptomatology seems hyperactive dysfunction syndrome of the cranial nerves. In the clinical picture, it can be seen trigeminal neuralgia, vertigo, tinnitus, hemifacial spasm, and in some cases hypertension.Case report: Female patient, 45 years ...

ea0032p985 | Thyroid (non-cancer) | ECE2013

Efficacy and safety of combined parenenteral and oral steroid therapy in Graves' orbitopathy

Beleslin Biljana , Ciric Jasmina , Zarkovic Milos , Knezevic Miroslav , Stojkovic Mirjana , Lalic Tijana , Nisic Tanja , Trbojevic Boza

Introduction: Glucocorticoids (GC) are the first line treatment for moderate-to-severe and active Graves’ orbitopathy (GO), but optimal treatment is still undefined. The aim of the present study was to analyze the efficacy and tolerability of combined parenteral GC pulse therapy followed by oral GC in the interpulse period.Methods: The study includes 50 patients (48±10 years; 37 females) with untreated, active and moderate-to-severe GO. Patient...

ea0029p434 | Clinical case reports - Thyroid/Others | ICEECE2012

Primary hyperparathyroidism associated with autoimmune polyglandular syndrome type III and isolated IgA deficiency

Savic S. , Zarkovic M. , Ciric J. , Beleslin B. , Stojkovic M. , Nisic T. , Stojanovic M. , Trbojevic B.

Introduction: Isolated IgA deficiency (SIgAD) is the most common form of primary immunodeficiency. Patients with SIgAD have an increased risk of both systemic and organ-specific autoimmune diseases. Autoimmune thyroid diseases (AITD) and type 1 diabetes mellitus (T1DM) are the most common autoimmune endocrine disorders. They occur frequently together, and this combination is nominated as autoimmune polyglandular syndrome type 3 (APS 3). Primary hyperparathyroidism (PHPT) is th...

ea0029p980 | Female Reproduction | ICEECE2012

Differences in gonadal axis reaction to ketoconasole between PCOS and healthy individuals

Stojkovic M. , Savic S. , Beleslin B. , Ciric J. , Trbojevic B. , Zarkovic M.

Background: Ketoconazole is a synthetic antifungal drug, and powerful inhibitor of steroidogenesis. Oral ketoconazole blocks both ovarian and adrenal androgen biosynthesis, and glucocorticoid synthesis, leading to a reduction in circulating testosterone and cortisol levels. In subjects with an intact HPA axis, ketoconazole by decreasing cortisol levels leads to compensatory rise an ACTH level.Objectives: To assess influence ketoconasole induced changes i...

ea0022p793 | Thyroid | ECE2010

Differences in Graves' orbitopathy between hyperthyroid and hypothyroid/euthyroid patients

Beleslin Biljana , Ciric Jasmina , Zarkovic Milos , Stojkovic Mirjana , Ciric Slavica , Knezevic Miroslav , Trbojevic Bozo

Aim: The aim of this study was to compare clinical symptoms and TSH receptor antibodies (TRAb) in Graves orbitopathy (GO) in hyperthyroid patients to those patients with primarily hypothyroid and euthyroid status.Methods: Study group consisted of 54 primarily hyperthyroid (39 female, 14 male, 47±9 years) and 8 primarily hypothyroid and euthyroid patients (5 female, 3 male, 46±14 years). Clinical symptoms and TRAb were assessed. Assessment of th...

ea0020p605 | Neuroendocrinology, Pituitary and Behaviour | ECE2009

Hypothalamic–pituitary–adrenal axis in chronic fatigue syndrome

Marina Djordje , Jelic Svetlana , Kostic Nada , Caparevic Zorica , Trbojevic Bozo , Beleslin Biljana , Ilic Sanja , Zarkovic Milos

Background/objectives: The aim of the study was to assess hypothalamic–pituitary–adrenal (HPA) axis in patients with chronic fatigue syndrome (CFS).Design and methods: Twenty-three consecutive patients who fulfilled centers for disease control (CDC) criteria for CFS and twenty healthy controls were included in the study. Low dose ACTH test (1mcg of synthetic adrenocorticotropic hormone Synacthen) and insulin tolerance test (ITT) were done and b...

ea0016p24 | Adrenal | ECE2008

Association of diabetes mellitus and arterial hypertension in adrenal incidentaloma

Zarkovic Milos , Ciric Jasmina , Beleslin Biljana , Savic Slavica , Stojkovic Mirjana , Marina Djordje , Trbojevic Bozo

Background/objectives: The aim of the study was to assess association between diabetes mellitus (DM) and arterial hypertension (AH) in patients with adrenal incidentaloma.Design and methods: One hundred and eleven consecutive patients with incidentally discovered adrenal tumours were included in the study. OGTT was done and 24 h urinary catecholamines were measured. Aldosterone and plasma renine activity (PRA) were determined, and 1 mg dexametasone test ...

ea0016p619 | Reproduction | ECE2008

Intima-media tickness of carotid artery in young women with polycystic ovary syndrome

Stojkovic Mirjana , Civcic Milorad , Beleslin Biljana , Ciric Jasmina , Savic Slavica , Marina Djordje , Trbojevic Bozo , Zarkovic Milos

Background: Polycystic ovary syndrome (PCOS) is a common endocrine-metabolic disease that occurs in about 10% of women in reproductive age. Today, PCOS is considered not only reproductive edocrinopathy but also a metabolic disorder associated with long-term health risks, including diabetes mellitus and cardiovascular disease.Objectives: The aim of this study was to evaluate the presense of early vascular demage in normal-weight women with polycystic ovar...