Searchable abstracts of presentations at key conferences in endocrinology

ea0029p911 | Female Reproduction | ICEECE2012

The polymorphic variants K121Q of the plasma cell membrane glycoprotein and G972R of the insulin receptor substrate-1 modulate in opposite ways the clinical and biochemical profiles of women with polycystic ovary syndrome

Pappalardo M. , Trimarchi F. , Benvenga S.

Background: Insulin resistance (IR) is the common denominator of three multigenic disorders: type 2 diabetes mellitus, obesity, and PCOS. IR can result from genetic abnormalities involving proteins of the insulin signalling pathway, including PC-1 and IRS-1. The IRS-1 G972R variant had the highest world frequency and correlated with IR in PCOS Sicilian women (Horm Metab Res, 2010).Objective and methods: To determine: i) the rates of the G972R IRS-...

ea0037ep75 | Adrenal cortex | ECE2015

Biochemical control and clinical improvement is induced by long-term pasireotide administration in the majority of patients with Cushing's disease persistent after pituitary surgery

Messina Erika , Albani Adriana , Ferrau Francesco , Trimarchi Francesco , Cannavo Salvatore

Pasireotide (SOM230) is a multireceptor ligand somatostatin analogue with high binding affinity to somatostatin receptor subtype 5, which is predominantly expressed in ACTH-secreting pituitary adenomas. It is indicated for the treatment of adult patients with Cushing’s disease (CD) for whom pituitary surgery is not an option or has not been curative. Our study evaluated the effects of pasireotide, administered for 12 months at a dose of 600–900 μg/daily, in five...

ea0029p1626 | Thyroid (non-cancer) | ICEECE2012

A liquid formulation of L-thyroxine (L-T4) solves problems of incomplete normalization/suppression of serum TSH caused by proton pump inhibitors (PPI) on conventional tablet formulations of L-T4

Saraceno G. , Vita R. , Trimarchi F. , Benvenga S.

Background: PPI are known to diminish the intestinal absorption of L-T4, which is commonly ingested as tablets of L-T4 sodium salt. However, a liquid formulation is available (Tirosint, oral solution, IBSA Farmaceutici Italia s.r.l., Italy), in which the hormone is solubilized in 28.8% ethyl alcohol. One ml of this formulation (=28 drops) contains 100 mcg L-T4 sodium salt in 243 mg ethanol. Because this formulation contains L...

ea0081p738 | Thyroid | ECE2022

Predictors of associated autoimmune diseases in patients with Hashimoto′s thyroiditis.

Ruggeri Rosaria , Trunfio Francesca , Giuffrida Giuseppe , Trimarchi Francesco , Campenni Alfredo , Cannavo Salvatore

Background: Increased rates of autoimmune diseases (ADs) have been reported in association with Hashimoto′s thyroiditis (HT); however, the risk factors for coexisting ADs in HT patients have been poorly investigated.Objective: To evaluate the prevalence and factors associated with AD comorbidities in patients with HT.Materials and Methods: We recruited 687 patients (626 F and 61 M, mean age at diagnosis 39 ± 14.06 yr, F:...

ea0084ps2-06-56 | Hypothyroidism Treatment | ETA2022

Polychlorinated biphenyl congeners PCB 118 and PCB 126 induce upregulation PD-L1 expression in human thyrocytes through aryl hydrocarbon receptor (AHR) pathways

Ruggeri Rosaria , Minuti Aurelio , Aliquo Federica , Giani Fiorenza , Campenni Alfredo , Trimarchi Francesco , D'Ascola Angela , Cannavo Salvatore

Objective: Polychlorinated biphenyls (PCBs) are persistent organic pollutants that that have been reported to cause a variety of toxic effects, including inflammation and cancer, through binding to the aryl hydrocarbon receptor (AhR). In turn, AhR promotes xenobiotic detoxification and antioxidant defense, by up-regulating specific responsive genes, the so-called “AhR gene battery”. AhR is also involved in modulation of immune response, by regulating programmed cell ...

ea0063gp178 | Benign Thyroid Disorders | ECE2019

Cystic fibrosis as a novel cause of thyroxine (l-t4) malabsorption and increased requirement

Giuffrida Giuseppe , Magazzu Giuseppe , Campenni Alfredo , Lucanto Maria Cristina , Trimarchi Francesco , Cannavo Salvatore , Ruggeri Rosaria Maddalena

Background: Cystic fibrosis (CF), a monogenic disease from mutations in the CFTR gene on chromosome 7, causes pancreatic insufficiency and impaired nutrients absorption. Unlike other malabsorption disorders, no data are available in literature on L-T4 absorption in CF. This study analyzed L-T4 absorption and requirement in hypothyroid CF patients.Methods: Ten CF patients (7 F, 3 M; mean age 37 yr), with autoimmune (n=6) or post-thyroidectomy (<e...

ea0029p1345 | Pituitary Basic | ICEECE2012

Increased interleukin 22 circulating levels in patients with tumors involving the hypothalamic-pituitary region

Cotta O. , Gangemi S. , Ferrau F. , Saitta S. , Torre M. , Puglisi S. , Trimarchi F. , Cannavo S.

Introduction: Cytokines have been suggested to be involved in modulating anti-tumor responses and promoting tumor growth. Some studies have indicated that cytokines could also be involved in the pathogenesis of pituitary tumors. Th17 cells, characterized by expression of several cytokines as interleukin 22 (IL 22), might have a role in tumor immune-surveillance. IL-22 is a cytokine involved in the modulation of tissue responses during inflammation and, through activation of St...

ea0029p1572 | Thyroid (non-cancer) | ICEECE2012

Gestational hyperthyroidism in women from mild to moderate iodine deficiency (ID) areas

Presti S. , Moleti M. , Di Bella B. , Sturniolo G. , Di Mauro F. , Trimarchi F. , Vermiglio F.

Graves’ disease (GD) and gestational transient thyrotoxicosis (GTT) are the main causes of hyperthyroidism in pregnancy, their prevalence ranging between 0.1–0.4% and 0.3–11%, respectively.Aim of the study: To evaluate both prevalence and outcome of gestational hyperthyroidism in mild to moderate ID areas.Subjects and methods: 482 consecutive pregnant women who had never undergone thyroid function evaluation before a...

ea0016p455 | Neuroendocrinology | ECE2008

Systemic comorbidities induce early vascular alterations in patients with active acromegaly

Ferrau Francesco , Romanello Giovanni , Squadrito Stefano , Carerj Scipione , Nipote Carmelo , Iudicello Raffaella , Trimarchi Francesco , Cannavo Salvatore

Mortality risk is increased in acromegalics, due to cerebrovascular and cardiovascular events. These events are namely related to atherosclerotic vascular alterations, both at coronary and peripheral level. Systemic comorbidities increase the risk of atherosclerosis, but the role of GH and IGF-1 excess is still debated. To evaluate the relationship between GH/IGF-1 excess, systemic atherogenic complications and vascular alterations we investigated stiffness index (β), pul...

ea0011p628 | Neuroendocrinology and behaviour | ECE2006

Sleep disorders in acromegaly: preliminary data demonstrating a high prevalence of restless leg syndrome (RLS)

Cannavo S , Condurso R , Squadrito S , Romanello G , Arico I , Mento G , Trimarchi F , Silvestri R

Sleep related breathing disorders (SRBD), due to bone mass and soft tissue swelling of the upper airways, are frequently reported by acromegalic patients, but sleep disorders other than SRBD were rarely studied in acromegaly. We evaluated 38 acromegalics (14 M, 24 F, age 52.8±2.3 yrs) by a structured interview for insomnia, excessive daytime sleepiness (EDS), SRBD, sleep related movement disorders (SRMD), circadian sleep disorders and parasomnias. Epworth sleepness scale ...