Endocrine Abstracts

It is well known that there exists a correlative relationship between diabetes mellitus (DM) and sex hormone levels. However, it has not yet been found if it is caused either by hyperinsulinemia, or hyperglycemia or insulin resistance (IR). Eighty-one men with DM and 35 healthy men with normal glucose levels were examined. In each group the persons were divided into four age subgroups: 36–45 years old, 46–55, 56–65 and 66–75 years old. IR was estimated usin...

Background: The male preponderance among 15–30 yrs old patients with type 1 diabetes mellitus (T1DM) was repeatedly described. All-age gender distribution assessment was not done yet because of the difficulties in the type of DM recognition in insulin-treated (IT) patients diagnosed after 30 yrs of age. The possibility of such assessment has arisen from the use of population-based DM registers by patients stratification depending of their disease history.<p class="abs...

Introduction: The increased risk of cancer in patients with diabetes mellitus (DM) creates an interest in finding mechanisms of the possible association of antidiabetic drugs and carcinogenesis. Metformin has the most documented evidence of pleiotropic oncoprotective effects, including increased stabilization of tumour suppressor p53, inhibition of NF-κB activation, slowing of the cell cycle and inhibition of mitosis due to decreased expression of cyclin D and cyclin E, a...

Purpose: Thyroid cancer (TC) is the most common endocrine cancer worldwide, affecting mainly women of the reproductive age. However, no data exist with regard to its association with endometrial or uterine disorders. The aim of this study was to assess the risk of hyperproliferative pathology of the reproductive system in female TC survivors.Methods: This was a cross-sectional study in female patients, aged 20-45 years, diagnosed with papillary TC (PTC) ...

Introduction: Postoperative hypoparathyroidism is a rare, but complex endocrine disorder. The purpose of this study was to evaluate the symptoms, signs and sequelae of the disease in a major patient group in the post-Chernobyl era using a new questionnaire instrument.Methods: A random sample of 25 patients with symptomatic permanent hypoparathyroidism was chosen out of a group of 158. The patients underwent physical examination, determination of parathyr...

Diabetes mellitus is a global social and medical problem. In the world, there are 463 million diabetic patients, and in 2045 it is expected to be 700 million (IDF DIABETES ATLAS, Ninth edition 2019). In Ukraine, diabetes affects 7.6% of the Ukrainian population, which is 2.5 million people. According to changes in the public health system, we have separate registration of people with diabetes who receive insulin, but it does not include all diabetic patients. Previous years we...