Endocrine Abstracts

Introduction: Results of many studies indicate that the BsmI and FokI polymorphisms in the VDR gene may influence bone tissue metabolism and may be useful in means of identifying patients at greater risk of osteoporosis.Aim of the study: To determine frequency of polymorphic variants of VDR gene (BsmI and FokI) and its relationship to phenotypic features characterizing bone status (BMD).Materials and methods: 176 randomly selected ...

Introduction: It was found that vitamin D could have a direct effect of on adipocyte differentiation and metabolism and might be involved in glucose regulation of insulin secretion, which may be speculated from finding of a nuclear localization of 1,25-(OH)2D3 in the pancreatic islets. In recent years several polymorphisms in VDR gene, which are potent to alter the activity of VDR protein, have been described. BsmI and FokI polymorphisms were described in...

Introduction: Insulin resistance (IR) and visceral obesity, elements of metabolic syndrome (MS), contribute to hyperandogenaemia and may lead to hirsutism and other signs of hyperandrogenism. Little is known about the influence of metformin therapy (MET) on hormonal profile in women with MS and IR without menstrual irregularity.Aim: To asses the influence of MET on sex steroids concentrations in young women with MS.Methods: The stu...

Introduction: Metformin (MET) is mainly used in diabetes mellitus type 2 (DM2) therapy. Little is known about its effects in patients with metabolic syndrome (MS) and insulin resistance (IR) without DM2.Aim: To asses the influence of MET on carbohydrate metabolism in young prediabetic women with MS.Materials and methods: The study population: 30 women with MS aged 25–45 years before (M1) and after (M2) ME...

Introduction: Metabolic syndrome (MS) is connected to atherogenic dyslipidemia. Data concerning influence of metformin (MET) therapy on lipid profile in nondiabetic women with MS remains unclear.Aim: To asses the influence of MET on selected lipid, apolipoproteins AI, B concentrations and atherogenic indexes values in young women with MS.Materials and methods: The study population: 30 women with MS aged 25–45 years before (M<s...

Glypican-4 (Gpc-4) is novel adipokine interact with insulin receptor and affects insulin sensitivity in proteoglycans. Gpc-4 serum levels show gender differences; females having higher levels than men, what can suggest mediation by sex hormones. We investigated serum Gpc-4 levels and its association with cardiovascular risk predictors in women (20–35 years old) with PCOS (n=62) and healthy control (n=43) presented different sex hormones profile. The foll...

Plasticisers such as bisphenol A (BPA), bisphenol S (BPS), and phthalates (PAE) are commonly used in daily life in electronic equipment, cans, plastic food containers, and bottles. These substances can interact with oestrogen receptors as well as androgen receptors and therefore they are called endocrine disrupting chemicals (EDC). The aim of this study was to evaluate serum concentrations of BPA, BPS, and selected PAE in healthy women and women with polycystic ovary syndrome ...

Polycystic ovary syndrome (PCOS) is the most common endocrinopathy in women of reproductive age, that lead to infertility, type 2 diabetes and coronary heart disease.Bisphenol A (BPA) is one of the most abundant chemicals produced worldwide and is used as a plasticizer in daily life. Nowadays it is also well know that it can interact with estrogen receptors, androgen receptors and peroxisome proliferator-activated receptors γ (PPARγ). Therefore...

The endocannabinoid system has been suspected to contribute to the association of visceral fat accumulation with metabolic diseases. Insulin resistance play important role in etiology in PCOS. The aim of our study was developed the role of CNR1 polymorphisms (rs806368, rs12720071, rs1049353, 806381, rs10485170, rs6454674, rs2023239) in metabolic disorders in woman with PCOS. 88 woman (20–35 years old) with PCOS (recognized using Rotterdam criteria) and 77 woman (20–3...