Searchable abstracts of presentations at key conferences in endocrinology

ea0011p346 | Diabetes, metabolism and cardiovascular | ECE2006

Metabolic syndrome among patients with primary aldosteronism: a common feature?

Giacchetti G , Ronconi V , Turchi F , Agostinelli L , Rilli S , Boscaro M

In the light of recent data reporting a high rate of cardiovascular events in Primary Aldosteronism (PA) we investigated whether the Metabolic Syndrome (MS) represents a common feature in patients with PA. A cohort of 86 patients, mean age 51±12 yr was analysed: 59 patients (26 females and 39 males) with idiopathic hyperaldosteronism (IHA) and 27 patients (13 females and 14 males) with aldosterone producing adenoma (APA). Anthropometric parameters (height, weight, waist c...

ea0011p347 | Diabetes, metabolism and cardiovascular | ECE2006

Metabolic parameters in patients with primary aldosteronism: relation to snps of the adiponectin gene

Ronconi V , Agostinelli L , Turchi F , Rilli S , Boscaro M , Giacchetti G

Adiponectin, a recently discovered protein which is secreted by the adipose tissue, exerts anti-inflammatory and anti atherogenic properties, but also promotes glucose uptake by skeletal muscle and fatty acids oxidation. Patients with hypertension and obesity have reduced plasma levels of adiponectin so that they lack its beneficial metabolic effects. However no data are available in patients with primary aldosteronism (PA). In order to investigate the role of the adiponectin ...

ea0009p30 | Diabetes and metabolism | BES2005

Gene polymorphisms related to metabolic and cardiac complications in patients with primary aldosteronism

Ronconi V , Agostinelli L , Turchi F , Rilli S , Mantero F , Giacchetti G , Boscaro M

Primary aldosteronism (PA) is characterized by development of cardiovascular and metabolic complications. We retrospectively analyzed 78 patients with PA: 29 had aldosterone-producing adenoma (APA), and 49 had idiopathic hyperaldosteronism (IHA). The study of complications was performed by examining the lipid and glucose profiles (OGTT, HOMA and Quicki indexes) and the echocardiographic parameters. Single-nucleotide polymorphisms (SNPs) of the aldosterone synthase (minus 344C/...

ea0029p1343 | Pituitary Basic | ICEECE2012

Aryl hydrocarbon receptor interacting protein in somatotroph adenomas: a molecular target for somatostatin analogues?

Jaffrain-Rea M. , Angelini M. , Occhi G. , Turchi A. , Castermans E. , Ceccato F. , Arcella A. , Esposito V. , Giangaspero F. , Pennelli G. , Daly A. , Alesse E. , Scaroni C. , Beckers A.

The aryl hydrocarbon receptor interacting protein (AIP) gene is abundantly expressed in normal somatotrophs. Somatotropinomas in patients with germline AIP mutations (AIPmut) are typically more aggressive than non-AIPmut adenomas and associated with higher GH/IGF1 secretion. AIP downregulation may also occur in sporadic somatotropinomas, especially in invasive tumours. We wished to evaluate the impact of somatostatin analogues (SSA) pre-treatment on AIP expression in sporadic ...

ea0022p300 | Diabetes | ECE2010

Inpatient hypoglycaemia: the continuing problem and need for a proactive management protocol

Sobajo Cassandra , Rao-Balakrishna Prasanna

Hypoglycaemia is defined as capillary blood glucose (CBG) of ≤4 mmol/l irrespective of symptoms. We audited the recognition and management of inpatient hypoglycaemia with a view to identify potential areas for improvement.Methods: A total of 120 inpatients with diabetes were identified in the hospital on a single day, of whom n=32 had ≥1 episode(s) of hypoglycaemia, as evidenced by their CBG. Data relating to recognition and management...