Searchable abstracts of presentations at key conferences in endocrinology

ea0035p26 | Adrenal cortex | ECE2014

Recovery of the hypothalamo–pituitary adrenal axis following successful surgical treatment in various forms of Cushing's syndrome

Palimeri Sotiria , Tzanela Marinella , Assimakopoulou Athina , Tsagarakis Stlylianos

It is well known that successful treatment of Cushing’s syndrome (CS) leads to transient adrenal insufficiency due to suppression of the hypothalamo–pituitary–adrenal (HPA) axis by the long-standing cortisol excess. Reports on HPA recovery in recent years including CS patients with less florid clinical features are scarce. Herein we report our findings in a series of patients with various forms of CS successfully treated in our department over the last 15 years....

ea0014p547 | (1) | ECE2007

Effect of treatment with somatostatin analogue on glucose homeostasis in patients with acromegaly

Gavalas Nikos , Sabo Andrea , Papastathopoulou Lida , Botoula Efi , Tzanela Marinella

Long acting somatostatin analogues (SMS) are extensively used as second and even first line treatment of acromegaly. Except of the inhibition of GH secretion, somatostatin is a potent inhibitor of insulin secretion from the pancreatic b- cells. As defects of glucose homeostasis are very common in acromegaly, we decided to examine the effect of the control of GH hypersecretion with SMS on glucose metabolism.We study 44 acromegalic patients divided in 3 gr...

ea0049ep1047 | Pituitary - Clinical | ECE2017

Considerable delays to achieve adequate control in treating patients with acromegaly

Tzanela Marinella , Karapanou Olga , Giatra Christianna , Botoula Efstathia , Tiaka Elisabeth , Anastasia Lambraki , Tsagarakis Stylianos

Acromegaly is a rare disease that leads to considerable morbidity and mortality, both reversible by adequate control of the disease. However, patients that could be adequately controlled confront delays in achieving treatment targets. The aim of the present study was to estimate the time to disease control after diagnosis and the reason leading to control delays. We retrospectively studied 119 acromegalic patients (aged 46.4±12.5; 71 females). Following appropriate treatm...

ea0037ep79 | Adrenal cortex | ECE2015

Functional muscle capacity and daily physical activity deficits in patients with endogenous Cushing's syndrome

Assimakopoulou A , Louvaris Z , Balomenaki M , Chynkiamis N , Tzanela M , Vogiatzis I , Tsagarakis S

Cushing’s syndrome (CS) is a disease entity that through hypercortisolism affects all body’s tissues leading to increased morbidity, decreased quality of life and mortality. Muscles are among the tissues primarily affected. However, data on the impact of endogenous hypercortisolism on functional muscle capacity and daily physical activity levels are scarce. We studied 23 subjects with endogenous CS (mean age: 40.73±2.17 years) and 22 healthy aged and sex matched...

ea0035p950 | Steroid metabolism and action | ECE2014

Tissue cortisol vs lipolysis in ICU patients

Ilias Ioannis , Vassiliadi Dimitra , Theodorakopoulou Maria , Nikitas Nikitas , Tzanela Marinela , Apollonatou Sofia , Tsagarakis Stylianos , Dimopoulou Ioanna

Introduction: The interplay of cortisol (F) and adipose tissue is complex and in many aspects is still obscure. Plasma F has been shown to be positively associated with lipolysis.Aim: To study in adipose tissue indices of lipolysis vs tissue F with microdialysis (MD).Subjects and methods: We studied 46 mechanically ventilated patients with a diagnosis of septic/non-septic shock, systemic inflammatory response syndrome or s...

ea0032p28 | Adrenal cortex | ECE2013

The role of late-night salivary cortisol measurement in the diagnosis of subclinical hypercortisolism in patients with adrenal incidentalomas

Perogamvros I , Tzanela M , Koletti A , Tsirona S , Memi E , Tsagarakis S

The diagnosis of subclinical hypercortisolism (SH) is a challenging issue, especially as the high prevalence of adrenal incidentalomas (AI) is increasingly recognized. The diagnosis of subclinical hypercortisolism relies on a combination of tests that include overnight (ODST) or low dose dexamethasone suppression (LDDST), plasma ACTH, and 24-h urinary free cortisol (UFC). Late night salivary cortisol (LNSC) has been successfully used in the diagnosis of Cushing’s syndrome...

ea0032p896 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

Effect of treatment outcome on co-morbidities of Cushing's disease

Assimakopoulou Athina , Tzanela Marinella , Palimeri Sotiria , Karapanou Olga , Botoula Efi , Tsagarakis Stylianos

Generously supported by IPSEN)-->Endogenous hypercortisolism leads to increased morbidity and mortality. As Cushing’s disease (CD) is a rare disorder, data on co-morbidities outcome after current treatment interventions are scarce.We studied 78 patients with CD (67 females, 11 males, mean age 42.2±1.4 years), with a follow up of 90.8±7.8 months. All patients underwent transsphenoidal surgery (TSS...

ea0029p72 | Adrenal cortex | ICEECE2012

ACTH and cortisol responses to the combined DEXA-CRH test in patients with adrenal incidentalomas

Tzanela M. , Tsatlidis V. , Margelou E. , Tampourlou , Mazarakis N. , Piaditis G. , Tsagarakis S.

Adrenal incidentalomas (AI) are a common finding in patients studied by abdominal imaging and approximately 9–17% is found bilaterally. So far, the potential role of hypothalomo-pituitary adrenal (HPA) axis dysregulation in the pathogenesis of AI, especially of those found bilaterally, has not been addressed. The DEXA-CRH test has been previously used to detect dysregulation of the HPA axis; herein, it was used to assess ACTH and cortisol responses in a large group of pat...

ea0029p1513 | Pituitary Clinical | ICEECE2012

Therapeutic trends, long-term outcome and efficacy of different treatment modalities in acromegaly: a single center registry covering a 40 year period

Tzanela M. , Karapanou O. , Assimakopoulou A. , Papastathopoulou L. , Christophoraki M. , Tsagarakis S.

The aim of the study was to examine the therapeutic trends and the long-term outcome of available therapeutic modalities for acromegaly in a single center over a 40 year period.We retrospectively studied 300 acromegalic patients (131 men, 169 women, 153 macroadenomas and 147 microadenomas) from 1970 until 2010; 154 patients were diagnosed before 1990 (group A) and 146 after 1990 (group B). Outcome was evaluated by IGF1 and GH (random plus post OGTT) meas...

ea0022p701 | Obesity | ECE2010

The circulating pattern of adiponectin and resistin in critically ill patients with sepsis

Vassiliadi Dimitra , Tzanela Marinella , Dimopoulou Ioanna , Orfanos Stylianos , Kotanidou Anastasia , Armaganidis Apostolos , Tsagarakis Stylianos

Several alterations of the metabolic processes develop during sepsis. Adiponectin and resistin are amongst the main adipokines that may contribute to the metabolic adaptations observed in the context of critical illness. However, there is scarce data on the circulating pattern of these adipokines in human sepsis. Therefore we aimed to describe the variation in circulating levels of resistin and adiponectin during the course of sepsis and examine whether they are related to the...