Searchable abstracts of presentations at key conferences in endocrinology

ea0090rc11.5 | Rapid Communications 11: Late Breaking | ECE2023

Pregnancy after bariatric surgery – Experience from a tertiary hospital

Urbano Ferreira Helena , von Hafe Madalena , Dias Helena , Goncalves Juliana , Rodrigues Teresa , Belo Sandra , Freitas Paula

Introduction: Maternal obesity is associated with an increased risk of gestational diabetes, large for gestational age (LGA) newborns, preterm delivery, congenital malformations, and fetal death. On the other hand, bariatric surgery before pregnancy is associated with a reduction of obesity-associated complications, but also with an increased risk of small for gestational age (SGA) newborns, fetal growth restriction and micronutrient deficiencies during pregnancy.<p class=...

ea0090ep64 | Adrenal and Cardiovascular Endocrinology | ECE2023

Cushing’s Syndrome due Primary bilateral macronodular adrenal hyperplasia–a case series from a tertiary hospital

Goncalves Juliana , Ferreira Helena Urbano , Pedro Jorge , Carvalho Davide , Freitas Paula

Primary bilateral macronodular adrenal hyperplasia (PBMAH) is a rare cause of Cushing’s syndrome (CS). It is a highly heterogeneous disease with multiple adrenal macronodules and variable levels of cortisol excess. The pathogenesis is complex and different mechanisms such as aberrant hormone receptors, local production of ACTH in adrenal tissues and genetic mutations have been identified. The approach is not well established. Nine patients with PBMAH who are currently fol...

ea0090ep82 | Adrenal and Cardiovascular Endocrinology | ECE2023

Black adrenal adenoma mimicking an oncocytoma–a case report

Urbano Ferreira Helena , Goncalves Juliana , Belo Sandra , Carvalho Davide , Freitas Paula

Introduction: Black adrenal adenomas are rare and benign. They are named after their black appearance, due to lipofuscin pigment. Most frequently black adenomas are associated with ACTH-independent Cushing’s syndrome. They can also cause primary hyperaldosteronism or be nonfunctioning. Unlike most other adrenal adenomas, black adenomas exhibit high Hounsfield units (>30) on CT, and high standard uptake value on FDG-PET.Case presentation: A 67-ye...

ea0090ep717 | Pituitary and Neuroendocrinology | ECE2023

Bilateral petrosal sinus sampling – a 15-year experience from a tertiary hospital

Ferreira Helena Urbano , Goncalves Juliana , Belo Sandra , Alves Goncalo , Silva Maria Luis , Carvalho Davide , Freitas Paula

Introduction: In patients with ACTH-dependent Cushing Syndrome, differentiating between pituitary and ectopic sources can be challenging. Noninvasive testing can be performed, but bilateral inferior petrosal sinus sampling (BIPSS) remains the gold standard. In the last years however, novel imaging modalities, namely 3T-MRI with 3-dimensional spoiled gradient-echo sequence and 68Ga-tagged CRH combined with positron emission tomography, have been proposed as alternatives.<p ...

ea0049ep970 | Pituitary - Clinical | ECE2017

Somatostatin analogues-induced diabetes mellitus in acromegalic patients reverts after drug withdrawal: a long-term study

Cappellani Daniele , Urbani Claudio , Sardella Chiara , Marconcini Giulia , Marcocci Claudio , Rossi Giuseppe , Bogazzi Fausto

Context: Therapy with somatostatin analogues (SSAs) may have deleterious effects on glucose metabolism in patients with acromegaly, often leading to development of diabetes mellitus (DM).Aim of the study: To evaluate whether DM, which developed during therapy with SSAs, may revert after drug withdrawal and cure of acromegaly with pituitary adenomectomy.Design: Retrospective cohort study, in a tertiary referral center.<p class="...

ea0037ep1219 | Clinical Cases–Pituitary/Adrenal | ECE2015

Autoimmune hypophysitis: from pituitary expansion to empty sella: description of four cases

Marconcini Giulia , Lupi Isabella , Manetti Luca , Cosottini Mirco , Urbani Claudio , Martino Enio , Marcocci Claudio , Bogazzi Fausto

Four patients with autoimmune hypophysitis were followed since the diagnosis of the disease. All presented with severe headache, decreased libido, astenia. Case 1 and 3 presented polyuria and polydipsia. At MRI pituitary was enlarged, with high gadolinum uptake and stalk enlargement.Case 1, male 41 years. MRI volume: AP 13 mm, CC 7 mm. Hormonal assessment: central hypothyroidism, hypoadrenalism, hypogonadism, normal GH and IGF1, hyperprolactinemia, centr...

ea0070aep1065 | Hot topics (including COVID-19) | ECE2020

Efficacy and safety of long-acting pasireotide in acromegalic patients in the real life: The reappraisal of the first-dose follow-up visit

Urbani Claudio , Dassie Francesca , Zampetti Benedetta , Maria Di Certo Agostino , Cozzi Renato , Maffei Pietro , Bogazzi Fausto

Background: Pasireotide is a multi-ligand somatostatin analogue licensed in a long-acting release formulation (PAS-LAR) for the treatment of acromegaly. The real-life reports with PAS-LAR are still scanty.Objectives: To assess the efficacy and safety of PAS-LAR in patients with acromegaly.Patients and methods: Prospective observational multi-centre study enrolling acromegalics evaluated before (baseline) and 1, 6, 12, 24, and 36 mo...

ea0029p328 | Cardiovascular Endocrinology and Lipid Metabolism | ICEECE2012

Effect of medical therapy on 24-h blood pressure profile in acromegaly

Sardella C. , Nuzzo A. , Urbani C. , Lombardi M. , Scattina I. , Tomisti L. , Martino E. , Bogazzi F.

To investigate the blood pressure profile (BP) in active acromegaly and the effect of medical treatment of acromegaly on BP circadian rhythm, we studied 21 acromegalics before and after 3–60 months of treatment with somatostatin analogs (15/21) or pegvisomant (5/21) or both (5/21). Ambulatory 24-h BP was recorded. The 24-h mean BP (MBP), the mean systolic BP (SBP) and diastolic BP (DBP), the day-time (day) and night-time (night) MBP, SBP and DBP and the 24-h mean heart ra...

ea0029p1398 | Pituitary Clinical | ICEECE2012

Effects of medical therapy of acromegaly on glucose metabolism

Urbani C. , Calevro A. , Scattina I. , Lombardi M. , Sardella C. , Nuzzo A. , Marchello A. , Martino E. , Bogazzi F.

Introduction: Acromegaly is associated with alterations of glucose metabolism. The effect of somatostatin analogues (SMS) and pegvisomant (PEG) on glucose metabolism is still argument of debate.Study design: The purpose of this historical-prospective study was to compare, in a cohort of 47 patients with active acromegaly, the effects of SMS and PEG alone or in combination on glucose metabolism. All subjects were evaluated at baseline and at least 6 month...

ea0029p1465 | Pituitary Clinical | ICEECE2012

Colonic neoplasms in acromegaly: are there serum risk factors?

Lombardi M , Scattina I , Urbani C , Sardella C , Marchello A , Nuzzo A , Dell'Unto E , Martino E , Bogazzi F

Hyperinsulinemia has been associated to an increased risk of colorectal cancer and adenomas, while higher serum 25-hydroxy vitamin D3 and folate seem to reduce the development of colonic lesions in general population. Acromegalic patients have an increased risk of colonic tumors and an association between higher fasting insulin levels and risk of colonic adenomas has been previously demonstrated. No data are available about the influence of vitamin D and folate-homocysteine le...