Endocrine Abstracts

Dramatic improvements in cancer survival over the past four decades means that greater than 80% of children diagnosed with cancer can expect to survive for more than five years. For some cancers, such as acute lymphoblastic leukaemia and Hodgkin’s disease, cure rates exceed 90%. Currently, there are over 26000 young adults living in the UK, 600 000 across France, Italy, Switzerland, Netherlands and the Nordic countries and 363 000 in the US, who are survivors of childhood...

Approximately 1 in 650 children will develop a childhood malignancy by the age of 15 years. Improvements in diagnosis, treatment and supportive care over the last 30 years mean that approximately 80% of children diagnosed with cancer can now expect to survive more than five years. Approximately 1 in 250 young adults in the UK is a survivor (more than five years from end of therapy and disease-free) of childhood cancer. In the adult field it is estimated that 2 million people i...

Introduction: Children with type 1 diabetes mellitus (T1DM) are at increased risk of being overweight. Being overweight could be related to insulin requirements, female gender, and duration of diabetes. The aim of this study is to examine the Body Mass Index (BMI) of children and young people with T1DM at the Children’s Hospital for Wales and explore co-factors that may contribute to risk.Methods: A retrospective review of all patients with T1DM att...

3-M syndrome is an autosomal recessive primordial growth disorder characterized by pre- and post-natal growth restriction, facial dysmorphism and radiological abnormalities. Mutations in the gene CUL7 have been previously shown to cause 3-M syndrome. CUL7 is a member of the cullin family of E3 ubiquitin ligases involved in targeted protein degradation.We identified a large cohort of 3-M syndrome patients who did not carry CUL7 mutations but...