Endocrine Abstracts

Introduction/objective: The exact mechanism of autoimmune thyroid destruction in patients with Hashimoto’s thyroiditis (HT) remains unclear. Recently it has been found that the HT patients demonstrate increased levels of anti-DNA antibodies, which may be directed against various nuclear structures and may be involved in process of apoptosis. In this study, we examined the potential association between anti-DNA antibodies levels, thyroid function and activity of autoimmune...

The purpose of this study was to describe MRI signs of Hashimoto’s thyroiditis (HT) in patients from the iodine deficient region.30 euthyroid patients with HT from the iodine deficient region and 5 healthy individuals were examined by MRI in FSE T1 and T2 pulse sequences. The diagnosis was confirmed according to the standard criteria.The atrophic form of HT (2 cases) showed the reduction of thyroid volume with denominated lobu...

Objective: To study the effect of age and gender on manifestation of hyperprolactinaemia.Methods: Patients were examined using generally accepted methods of diagnosis. 207 patients with prolactinomas were divided into two groups: before and after 50 years. It was a retrospective study with no interventions to generally accepted methods of diagnosis and treatment. The outcomes were measured by frequency of hyperprolactinaemia symptoms according to age and...

Aim: To estimate pituitary disfunction development in patients with micro and macroadenonas before and after transnasal adenomectomy.Methods: A total of 222 patients at the age from 17 to 71 with pituitary adenomas were operated from 2007 to 2013. According to size the pituitary adenomas were classified as microadenomas (diameter less than 10 mm) and macroadenomas (more than 10 mm). Dynamic observation and redetermination of all hormones were performed w...

Introduction.: Circulating prolactin is predominantly monomeric, but when there presents more than 60% of polymeric, less bioactive forms, phenomenon of macroprolactinemia is diagnosed.For prolactinomas, serum prolactin levels generally parallel to tumor size, but tumor mass and prolactin levels may be dissociated due to hook-effect, when falsely low prolactin level observed. It is excluded by serial dilutions of serum samples.The ...

It is known that treatment of prolactinomas with dopamine agonists is accompanied by relapses of the disease after discontinuation of the treatment in about 50% of cases and long-term or lifelong medication is required. The aim of the study was to evaluate the effectiveness of surgery in achieving remission or biochemical control of the disease. We prospectively enrolled 32 consecutive patients with prolactinomas who underwent transsphenoidal resection performed by the highly ...

The mechanism of autoimmune destruction of thyrocytes in pathogenesis of Hashimoto thyroiditis remain unclear. It has been showed that the HT patients produce antibodies to DNA, which are directed against various structures of the nucleus and probably may be involved in process of apoptosis.In order to show that the increased production of anti-DNA antibodies is intrinsic property of HT, but not of another non-autoimmune thyroid diseases, we have measure...