Endocrine Abstracts

With the success of statins in lowering LDL cholesterol and reducing cardiovascular disease (CVD) event rate, interest is shifting towards HDL cholesterol (HDL-C) as a potential target for therapeutic intervention.High HDL-C is associated with low CVD event rate. Reverse cholesterol transport may contribute to this association, and describes transfer of cholesterol on HDL particles from peripheral tissues to the liver. The transport process involves: ATP...

Objective: To describe the clinical presentation of forefoot and midfoot diabetic foot ulcers (DFUs) complicated by osteomyelitis and their outcomes with conservative management in a multi-disciplinary care environment and determine predictors of ulcer healing.Methods: This is a retrospective study of all consecutive cases of DFUs complicated by osteomyelitis presenting to our multi-disciplinary diabetes foot clinic between 1st January and 30th June 2016...

Schizophrenia is associated with higher risk of Type 2 diabetes. There are several reports of Type 2 diabetes presenting as diabetic ketoacidosis, particularly in young obese African-Caribbean subjects. We report 3 cases of new onset diabetes presenting with diabetic ketoacidosis (see Table 1) in African-Caribbean males treated with olanzapine for chronic schizophrenia.Table 1 Metabolic parameters on admissionCase</td...

Intracranial calcification seen on CT may be an incidental finding or it can be a direct cause of neurological symptoms depending on which areas of the brain are affected. The differential cause for the formation of intracranial calcium deposits include hypoparathyroidism, congenital infections i.e. toxoplasmosis and Fahr’s syndrome.A 50–year–old woman was referred to the transient ischaemic attack (TIA) clinic in December 2011, with recur...

A 69-year-old Iraqi lady presented with a 4-day history of diplopia, headache and right eye swelling. She had a pituitary adenoma diagnosed in Beirut when she was 20 years old and underwent trans-frontal surgeries and radiotherapy twice and further transsphenoidal surgery in 1980. She was on prednisolone 2 mg+1 mg and thyroxine 50 mcg daily.She initially presented to the ophthalmology clinic. Examination revealed a pupil-sparing 3rd nerve palsy of the ri...

A 69-year-old lady presented with a 4-day history of diplopia, headache and right eye swelling. She had a pituitary adenoma diagnosed in Beirut when she was 20 years old and underwent trans-frontal surgeries and radiotherapy twice and further transsphenoidal surgery in 1980. She initially presented to the ophthalmology clinic. Examination revealed a pupil-sparing 3rd nerve palsy of the right eye, with complete ptosis, proptosis and reduced visual acuity (6/9). She was referred...

The Charcot joint was originally described as tabetic arthopathy and published in 1868. This occurs in approximately 0.2% of people with diabetes and usually involves a prior peripheral neuropathy. Other factors involved in the pathogenesis of this osteoarthropathy are autonomic neuropathy & trauma.A 74-year-old male presented in August 2004 with a subacute history of right foot swelling & discomfort. There was no discreet history of preceding tr...

Non-alcoholic steatohepatitis is part of the spectrum of non-alcoholic fatty liver disease. It is characterised by triglyceride deposition in the liver associated with a lobular hepatitis and elevated circulating aminotransferases. It is associated with insulin resistance and commonly occurs in Type 2 diabetes but is much less widely recognised in patients with Type 1 diabetes.A 29 year old Caucasian male with longstanding Type 1 diabetes presented with ...