Endocrine Abstracts

Pluripotent stem cells (PSC), both embryonic and induced (iPSC), are the most promising cell sources for replacement therapies. In particular for a disease like type 1 diabetes (T1D), caused by the loss of a single specific cell type that does not need to be transplanted back in its originating site to perform its function, a stem cell-based cell replacement therapy seems to be the ideal cure. At present, however, a successful strategy for the use of PSC in patients with diabe...

Neuroendocrine tumours (NETs) are heterogeneous neoplasm, arising from different endocrine cells distributed in many organs and tissues which share a common neuroendocrine phenotype. The neuroendocrine cells of the human body are confined to certain organs such as thyroid, pancreas or adrenals, or are dispersed throughout the body in the respiratory tract and abundantly in the intestinal mucosa. These cells belong to the diffuse endocrine cell system, which is the largest endo...

Background and Aim: The incidence of papillary thyroid microcarcinoma (mPTC) has dramatically increased in the last decades. The majority of these tumors remain small and clinically silent, only small number progress. Clinical practice guidelines currently suggest avoiding the cytological examination of subcentimeter nodules and reducing surgeries for mPTC. Several risk factors have been identified as strongly associated with a high-risk phenotype for mPTCs (e.g. gross nodal m...

Introduction: A subclinical inflammatory state in obesity may be the link between diabetes mellitus (DM) and atherogenesis. This study aimed to investigate the relationship between pro atherogenic factors (C reactive protein (CRP), interleukine 6 (IL-6), vascular adhesion molecular type 1 (VCAM-1)), and anti-atherogenic factor adiponectin in subjects with obesity and DM.Methods: One hundred and twelve subjects (51 men, 103 women) were enrolled: group DM ...

Protein ubiquitination modulates many physiological processes (e.g. cell proliferation). The ubiquitin-based signalling consists in both proteolytic and non-proteolytic functions: the first ones require modification of the target protein with polyubiquitination, a modification that induces the activation of the 26S-proteasome, whereas the second ones can be based on protein monoubiquitination. The recognition of ubiquitination diversity is dependent on specific Ub receptors th...

Diabetes technologies are evolving rapidly. They offer exciting opportunities to improve patient self-care but they may also be challenging for both patients and health-care providers. Thus, the use of technology may empower or burden. To understand and benefit from the use of these technologies we must first go beyond HbA1c, understand what truly matters to our patients, and what technology can provide in this setting. Available data on the use of technology including insulin...

Objective: We developed a novel dual-component molecular assay as an ancillary method to improve clinical decision-making in patients with cytologically indeterminate thyroid nodules. The assay includes next-generation sequencing (NGS) based detection of mutations in 23 thyroid cancer related genes and digital polymerase chain reaction (dPCR) evaluation of the expression levels of a microRNA strongly associated with thyroid cancer. The method was designed as a “rule-out&#...

Aim: To pay attention to the so rare symptom of diffuse toxic goiter (DTG) as fever.Materials and methods: We report about 5 patients (all females, aged 18–38, mean – 31). Before, all patients were examined for fever of unknown origin of long duration. After the others reasons of the febrile body temperature were excluded, DTG was diagnosed. DTG was confirmed by the results of the clinical, hormonal and immunological investigations (T- and B-ce...

Bilateral Macronodular Adrenal Hyperplasia (BMAH) is an uncommon cause (<2%) of endogenous Cushing’s syndrome, characterized by enlarged adrenal glands Althought the exact pathogenetic mechanism remains unclear, recently, it has been reported that aberrant expression of ectopic receptors, such as AVP, GIP, angiotensin II (AT1 receptor) catecholamine, LH, 5HT4 agonists, and leptin, evoked cortisol secretion, which escapes from cortisol-mediated feedback in BMAH. Here w...

The aim of the study was to evaluate the degree of muscle dysfunction and relationship of trunk muscle strength and body composition in patients with osteoporotic vertebral fractures (VFs). Methods. Study comprised 90 men and woman 40-80 years old with primary osteoporosis. Study group (n=60) included patients with at least 1 VF (confirmed by X-rays), control group (n=30) consisted of osteoporotic patients of the same age, BMI and BMD without any fracture. Trunk muscl...