Searchable abstracts of presentations at key conferences in endocrinology

ea0019p256 | Pituitary | SFEBES2009

A case of FSH secreting pituitary adenoma

Muralidhara Koteshwara , Vaughan Nick

A 43-year-old, previously well Asian male was found to have a large intrasellar mass when investigated with an MRI brain for a history of reduced hearing. He had no other clinical history. His visual fields were normal. The tumour had extended to the suprasellar cistern but there was no optic nerve compression. Pre-operative biochemistry showed mild panhypopituitarism with a 0900 a.m. cortisol of 135 mmols/l, a free T4 of 8.5 pmols/l, a free T3 of 3.2 pmo...

ea0031p289 | Pituitary | SFEBES2013

Maternal corticosterone regulates amino acid allocation to fetal growth in mice

Vaughan Owen , Sferruzzi-Perri Amanda , Fowden Abigail

Synthetic glucocorticoid administration during pregnancy reduces birth weight and increases disease risk in the offspring. This study investigated whether increasing maternal natural corticosterone levels, by endogenous stress or exogenous administration, alters fetal amino acid supply in the mouse.C57BL6/J dams (n=82) were exposed to daily restraint and subcutaneous saline injection (stress) or given corticosterone (cort, 82±11 &#...

ea0009p230 | Clinical | BES2005

Differential regulation of Urocortin 3 mRNA expression in the central nervous system by stress and glucocorticoids

Jamieson P , Li C , Vaughan J , Vale W

The CRF-related ligand Urocortin 3 (Ucn 3) is expressed in discrete subcortical areas with highest mRNA levels in the medial amgydala (MEA), hypothalamic median preoptic nucleus (MePO) and the rostral part of the perifornical hypothalamic area (PFN). Close anatomical association between major Ucn 3 terminal fields and the type 2-CRF receptor in hypothalamus, lateral septum and medial amygdala suggest it is well placed to modulate physiological processes including behavioural, ...

ea0031p22 | Bone | SFEBES2013

Renal replacement therapy to treat severe hypercalcaemic crisis: case series

Prague Julia , Mustafa Omar , Whitelaw Ben , Jenkins Rebeka , Crown Anna , Vaughan Nick , Schulte Klaus-Martin , Diaz-Cano Salvador , McGregor Alan

Background: The initial management of hypercalcaemia is well described: aggressive intravenous rehydration and subsequent intravenous bisphosphonates if required. Isolated case reports document the use of haemo/peritoneal dialysis and haemofiltration in the management of severe hypercalcaemia. We report three cases that required renal replacement therapy to treat severe hypercalcaemia.Case series: A 21-year-old male presented with abdominal pain and vomi...

ea0007p66 | Diabetes, metabolism and cardiovascular | BES2004

Testosterone-induced vasodilatation of isolated human mesenteric and pulmonary resistance arteries is independent of the vascular endothelium

Jones R , Rowell K , Pugh P , Shorthouse A , Adam I , Vaughan R , Rocco G , Hopkinson D , Channer K , Jones T

Testosterone reduces myocardial ischaemia in men with coronary artery disease, and improves symptoms and exercise capacity in men with heart failure, effects proposed to be due to testosterone-induced coronary, systemic and pulmonary vasodilatation. Endothelial-independent calcium channel antagonism is proposed as the effector mechanism from in vitro animal studies, but this has yet to be confirmed in humans.In the present study we have investigated the ...

ea0011p407 | Diabetes, metabolism and cardiovascular | ECE2006

Urocortin 2 mediates glucose utilization and insulin sensitivity in skeletal muscle

Chen A , Brar B , Choi CS , Rousso D , Vaughan J , Donaldson C , Smith S , Li C , Kim SN , Nagy T , Shulman G , Lee KF , Vale W

Skeletal muscle is the principal tissue responsible for insulin-stimulated glucose disposal and is thus the major site of peripheral insulin resistance. Urocortin 2 (Ucn2), a corticotropin releasing factor (CRF) family member and the type 2 CRF receptor (CRFR2) are highly expressed in skeletal muscle. To determine the physiological role of Ucn2, we generated mice deficient in this peptide. Using glucose and insulin tolerance tests and hyperinsulinemic euglycemic glucose clamp ...