Endocrine Abstracts

Objectives: The value of ultrasound in functional disorders can be significant. That is why the question arises on the use of ultrasound examination of thyroid gland and its echogenity as a screening method in early detection of disfunctions, primarily subclinical and clinical forms of hypothyreosis.Methods: Testing included 328 patients. All examinees underwent ultrasound examination of thyroid gland, the blood was taken for determination of FT4</s...

Relationship of body weight and blood pressure is very complex and still incompletely explained. Obesity, especially visceral, is one of the strongest predictors of arterial hypertension. Hypertension is six times higher in obese than in lean people, with its prevalence increases with an increase in BMI progressively. The mechanisms underlying hypertension in obese are not fully defined. The aim of this research was to determine the influence of various parameters on blood pre...

C reactive protein is a sensitive marker of subclinical inflammation. C-reactive protein is associated with obesity, diabetes mellitus and increased cardiovascular risk. The mechanism of elevated CRP levels could have connections with insulin resistance. Inflammation seems to have significant role in pathogenesis of diabetes and cardiovascular disease. The aim of this study is to show that the subjects with greater insulin resistance, measured by HOMA-IR have higher levels of ...

Fat tissue is highly active tissue, both metabolically and as endocrine tissue, which produced large number of bioactive peptides, known as adipocitokines. They seem to contribute in pathogenesis of obesity, insulin resistance, diabetes mellitus type 2, hypertension, hyperlipidemia, and vascular disease. Adipocitokines and low grade inflammation could be connection between obesity and coexisting diseases. This is the reason we believe that body weight reduction could have posi...

Objectives: It has been reported that metformin administration lowered TSH levels in patients with type 2 diabetes mellitus and hypothyreosis. The aim of the study was to investigate effect of metformin on TSH levels in type 2 diabetic patients with primary hypothyroidism and also in patient with type 2 diabetes mellitus only.Methods: We included in our study 9 type 2 diabetic patients with primary hypothyroidism on stable l-thyroxine replacement doses a...

Objectives: There are reports which suggests that TSH levels are independetly associated with components of metabolic syndrome. The aim of this study was to investigate the relatinship between thyroid stimulating hormone (TSH) and metabolic syndrome (MetS) in owerweight and obese euthyroid subjects.Methods: In 80 euthyroid owerweight and obese subjects, 44 women and 36 man, fasting blood semples were analyzed for glucose, triglycerides and HDL and estima...

Background and Aims: Insulin glargine is a long acting insulin analog that mimics normal basal insulin secretion without pronounced peaks. The aim of this study was to compare insulin glargine with NPH insulin for basal insulin supply in patients with type 1 diabetes.Materials and Methods: A total of 48 type 1 diabetics (mean age 27 yr, BMI 23,1 kg/m2) on long term intensive insulin therapy (IIT) were randomized into 3 different regimens of ba...

Background: The most common method for evaluation of a suspicious thyroid nodule is a fine needle aspiration biopsy (FNAB). Together with ultrasound examination, thyroid scanning using pertechnetate and functional thyroid testing it helps in distinguishing between benign and malignant disease.Objective: Aim of this study is to assess accuracy of FNAB in the diagnostic evaluation of thyroid nodules.Patients: We retrospectively analy...