Searchable abstracts of presentations at key conferences in endocrinology

ea0029oc6.2 | Female Reproductioin Basic | ICEECE2012

Ghrelin modulates fertilization, early embryo development and implantation

Luque E. , Vincenti L. , Stutz G. , Santillan M. , Ruiz R. , Fiol de Cuneo M. , Martini A.

Ghrelin (Ghr) acts as a link between energy balance and reproduction; hence, hyperghrelinemia reduces reproductive success. In addition, this hormone has an evident physiological role on reproduction, since Ghr and/or its receptor are synthesized by gametes/embryos and several reproductive tissues (including decidua/placenta); in addition, Ghr plasma concentration rises during gestation.The objectives of our study were to evaluate the effects of ghrelin ...

ea0049s23.1 | Endo Oncology: prolactin, GH and metabolic hormones in oncology pathogenesis (Endorsed by Endocrine Connections) | ECE2017

Prolactin regulation of prostate stem cells: potential implications in prostate cancer

Goffin Vincent

Prostate stem cells have been proposed to participate in prostate cancer initiation. Furthermore, based on their androgen-independence, they are suspected to trigger prostate cancer recurrence when the tumor is no longer responsive to anti-androgens. Therefore better understanding the regulation of this particular cell pool may have important therapeutic relevance. In the human prostate, expression of prolactin (PRL) and activation of its major downstream signaling effector St...

ea0037s7.3 | Novel mechanisms of central weight regulation | ECE2015

Hypothalamic tanycytes in metabolic regulation

Prevot Vincent

The survival of an organism relies on its ability to promptly, effectively and reproducibly communicate with brain networks that control food intake and energy homeostasis. To achieve this, circulating factors of hunger and satiety reflecting nutrient availability must cross the blood-brain barrier (BBB) to reach effectors neurons. A defect in this process invariably leads to uncontrolled body weight. Here we will discuss the key role played in this process by a peculiar type ...

ea0031se1.6 | (1) | SFEBES2013

Suspicious hypoglycaemia; was it insulin?

Marks Vincent

Hypoglycaemia – especially in elderly hospital in-patients – is far less uncommon in non-diabetic patients than was previously thought but is only very rarely due to accidental or malicious ‘insulin’ (including insulin analogues and sulphonylurea) administration. The question of when to suspect that this might be the case and how to confirm or refute it is one that crops up from time to time in every community. Sometimes it is relatively simple and easy to ...

ea0028oc3.4 | Obesity, thyroid and Addison's disease | SFEBES2012

Glucose absorption capacity of the mature adipose tissue is increased after Bardet-Biedl syndrome induced ciliary defect in adipocytes’ precursors

Marion Vincent

A defining trait of modern civilization is easy access to food combined with minimum energy expenditure. This unbalance is responsible for the emergence of considerable wide-spread obesity and its harrowing cortege of life-threatening complications such as type-2 diabetes. Rare genetic disorders that manifest with obesity are of great value in discovering new pieces of the jigsaw on the origins of obesity as they allow us to link a phenotype with a specific protein or group of...

ea0026s22.3 | Non traditional effects of pituitary hormones | ECE2011

Prolactin, stem cells and prostate cancer

Goffin Vincent

Androgen-independent recurrence is the major limit of androgen ablation therapy for prostate cancer. Identification of alternative pathways promoting prostate tumor growth is thus needed. Signal transducer and activator of transcription 5 (Stat5) has been recently shown to promote human prostate cancer cell survival/proliferation and to be associated with early prostate cancer recurrence. Stat5 is the main signaling pathway triggered by prolactin (PRL), a polypeptide hormone m...

ea0025s5.3 | The novel role of primary cilia in endocrine disease and obesity | SFEBES2011

The importance of primary cilium in adipogenic differentiation

Marion Vincent

Long considered as a vestige of evolution, the primary cilium has recently emerged as a crucial orgnalle in the regulation of cell function. Ciliated cells are ubiquitously present in the organism and until recently only two cellular types were considered as unciliated cells, namely the adipocyte and the hepatocyte. An in vitro approach evidenced that the preadipocyte was transiently ciliated during its terminal differentiation phase and that the primary cilium was acti...

ea0025s7.2 | Eat, bond, reproduce – what the hypothalamus dictates | SFEBES2011

The role of tanycytes in the regulation of the reproductive axis

Prevot Vincent

The neuroendocrine fraction of GnRH neurons sends axon to the median eminence of the hypothalamus where they release their neurohormone into the pituitary portal vasculature to regulate the reproductive axis. Specialized unciliated ependymal cells named tanycytes, which line the floor of the third ventricle, confer to the median eminence its peculiar cytoarchitecture. Tanycyte cell bodies are located in the ventral border of the third ventricle but they also send processes to ...

ea0050p048 | Bone and Calcium | SFEBES2017

Annual incidence of acute severe hypocalcaemia due to hypoparathyroidism: a 3 year consecutive study amongst patients with severe hypocalcaemia presenting to A&E

Davies Zoe , Vincent Royce , Aylwin Simon

Background: Patients with hypoparathyroidism may present acutely with hypocalcaemia and these patients may have multiple admissions; however, data on the incidence of acute and recurrent acute hypoparathyroidism are scarce in the literature.Aim: We wished to determine: (1) the causes of severe hypocalcaemia amongst A&E attendances (2) the incidence of acute hypocalcaemia due to hypoparathyroidism amongst A&E attendances, and (3) the incidence of ...

ea0050p048 | Bone and Calcium | SFEBES2017

Annual incidence of acute severe hypocalcaemia due to hypoparathyroidism: a 3 year consecutive study amongst patients with severe hypocalcaemia presenting to A&E

Davies Zoe , Vincent Royce , Aylwin Simon

Background: Patients with hypoparathyroidism may present acutely with hypocalcaemia and these patients may have multiple admissions; however, data on the incidence of acute and recurrent acute hypoparathyroidism are scarce in the literature.Aim: We wished to determine: (1) the causes of severe hypocalcaemia amongst A&E attendances (2) the incidence of acute hypocalcaemia due to hypoparathyroidism amongst A&E attendances, and (3) the incidence of ...