Searchable abstracts of presentations at key conferences in endocrinology

ea0022p454 | Endocrine tumours &amp; neoplasia (<emphasis role="italic">Generously supported by Novartis</emphasis>) | ECE2010

Peptide receptor radionuclide therapy and NETs: how to select patients?

Ahluwalia Rupa , McKane Gail , Vora Jiten , Vinjamuri Sobhan

Neuroendocrine tumors (NETs) are rare tumours arising from the gastroenteropancreatic axis. They are slow growing and often metastatic. Diagnostic workup requires imaging; both anatomical (ultrasound, CT, MRI) and functional (somatostatin receptor scintigraphy, PET).NETs strongly express somatostatin receptors (SSTRs) of five different subtypes (SSTRs1–5) with SSTR2 being the most common. Some NETs reflect hyperactivity of the guanethidine pathway. ...

ea0013p222 | AMEND Young Investigator's Award | SFEBES2007

Assessment of the efficacy and toxicity of 131I-metaiodobenzylguanidine (131I-MIBG) therapy for metastatic carcinoid tumours

Nwosu AC , Jones L , Poston GJ , Vinjamuri S , Pritchard DM , Vora JP

Introduction: 131I-Metaiodobenzylguanidine (131I-MIBG) is used as palliative therapy in patients with metastatic neuroendocrine tumours (NET), but can cause bone marrow suppression, hypothyroidism and renal impairment.Methods: Retrospective case note analysis identified 58 patients treated with between May 1996 and May 2006. We assessed the efficacy and toxicity of 131I-MIBG therapy in 49 of these patients (12men; mean age at diagnosis: 57.4 years; range...

ea0011p25 | Bone | ECE2006

Effects of growth hormone administration on parathyroid hormone sensitivity and bone mineral metabolism in established osteoporosis

Joseph F , Ahmad A , White HD , Joshi A , Durham B , Vinjamuri S , Ashawesh K , Fraser WD , Vora JP

Introduction: The beneficial effect of GH replacement on bone in AGHD patients is mediated by improvements in target organ sensitivity to PTH and phosphocalcium metabolism. In aging women with established osteoporosis, GH and IGF-1 concentrations are lower and administration of GH has been shown to increase bone turnover and BMD, but the mechanisms remain unclear.Methods: Fourteen postmenopausal women (63.4±2.1 years; mean BMD T score ± ...

ea0002p15 | Clinical case reports | SFE2001

An unusual case of primary hyperparathyroidism due to four individual ectopic adenomata: a case report and review of management options

Stanaway S , Haqqani M , Cave-Bigley D , Gill G , Vinjamuri S , Weston P

IntroductionPrimary hyperparathyroidism (PHP) due to adenoma or hyperplasia is common and is being increasingly diagnosed. Overall 80% are due to single adenoma, 15% to multiglandular hyperplasia, 3% to multiple adenomata (usually 2) and 2% to carcinoma. In 20-30% the glands will be ectopically placed, usually within the neck, though can be anywhere from the skull base to the diaphragm.Surgery is the treatment and a longterm debate...

ea0046p2 | (1) | UKINETS2016

68Gallium-DOTANOC (68Ga-DOTANOC) positron emission tomography (PET) imaging in Bronchial Carcinoids (BC): multicentre evaluation of its role in clinical practice

Lamarca Angela , Pritchard D. Mark , Westwood Thomas , Papaxoinis George , Vinjamuri Sobhan , Valle Juan W , Manoharan Prakash , Mansoor Wasat

Background: New nuclear medicine imaging techniques have improved diagnosis, staging and treatment planning for BC. 68Ga-DOTA PET is preferable to standard somatostatin receptor scintigraphy where available (ENETS guidelines); however, its role in the management of BC remains unclear.Methods: All consecutive patients diagnosed with BC from two ENETS Centres of Excellence were identified retrospectively; patients with high grade tumours or lack...

ea0009p66 | Growth and development | BES2005

The circadian rhythm of osteoprotegerin and its association with parathyroid hormone secretion

Joseph F , Chan B , Corlett P , Durham B , Ahmad A , White H , Wherley N , Vinjamuri S , Gallagher J , Fraser W , Vora J

BACKGROUD: Parathyroid hormone (PTH) is normally secreted in a circadian rhythm and modulates bone turnover through the differential stimulation of receptor activator for nuclear factor kappa-B ligand (RANKL) and suppression of osteoprotegerin (OPG), both of which are fundamental factors in regulating bone turnover. We have studied the relationship between PTH and OPG over a 24-hour period.METHODS: Hourly peripheral venous blood samples were obtained fro...

ea0060p18 | (1) | UKINETS2018

The impact of 68Ga-based PET-CT scanning on the management of patients with sporadic pancreatic neuroendocrine tumours (pNETs)

Cuthbertson Daniel , Barriuso Jorge , Pizanais Michail , Jaffa Matthew , Lamarca Angela , Vivian Gillian , Halloran Tom , Westwood Tom , Prachalias Andreas , O'Reilly Derek , Weismann Hulya , Martin Wendy , Vinjamuri Sobhan , Pritchard D Mark , Hubner Richard , Srirajaskanthan Raj , Ramage John , Raraty Mike , Ganeh Paula , Fenwick Steve , Valle Juan , Yip Vincent

Background: Pancreatic neuroendocrine tumours (panNETs) are rare tumours (prevalence 4/100,000). Diagnosis and staging of panNETs requires biochemical screening, cross-sectional imaging (with CT/MRI), endoscopic ultrasound (EUS) and where available, functional imaging using 68Ga-labelled synthetic octreotide analogues using PET-CT due to its reported higher sensitivity and specificity.Methods: A retrospective, electronic case note study was ca...

ea0060p30 | (1) | UKINETS2018

The impact of 68Ga-based PET-CT scanning on the management of patients with familial pancreatic neuroendocrine tumours (panNETs)

Cuthbertson Daniel , Barriuso Jorge , Pizanias Michail , Jaffa Matthew , Nuttall Christina , Vivian Gillian , Halloran Tom , Westwood Tom , Prachalias Andreas , Lalloo Fiona , Weismann Hulya , Martin Wendy , Vinjamuri Sobhan , Mark Pritchard D. , Fenwick Steve , Ganeh Paula , Raraty Mike , McNamara Mairead , Srirajaskanthan Raj , Ramage John , Manoharan Prakash , Yip Vincent

Background: Pancreatic neuroendocrine tumours (panNETs) may arise as part of an underlying genetic condition such as multiple endocrine neoplasia type 1 (MEN type 1). The value of functional imaging using 68Ga-labelled synthetic octreotide analogues using PET-CT has not been extensively evaluated in patients with MEN1 to determine its value.Methods: We investigated the effect of 68Ga-based PET-CT imaging on patient management in pat...