Endocrine Abstracts

The aim: To evaluate the efficiency and safety of using closed loop systems in patients with type 1 DM living in Russia.Results: 88 respondents (or those legal representatives) with type 1 DM in insulin therapy by closed loop systems, members of Russian-speaking community, were included to the study. 90% of respondents living in Russia. All respondents using do-it-yourself artificial pancreas systems (DIYAPS): Loop (19.3%), Open APS (30.7%) and Andr...

Background and aims: The most outstanding cardioprotective potential has been demonstrated for GLP-1 receptor agonists (GLP-1RA) and SGLT-2 inhibitors (SGLT-2i). But only long-acting GLP-1RA dulaglutide (DULA) and semaglutide decrease stroke incidence, while data concerning the influence of any drug on stroke severity are lack. At the same time, ischemic stroke remains one of the leading causes of death in type 2 diabetes mellitus (DM2). The aim of our study was to investigate...

Background and Aim: Type 2 diabetes mellitus (DM) treatment guidelines give preference to drugs with proven cardioprotective effect, which include sodium-glucose cotransporter type 2 inhibitors (SGLT-2i) and glucagon-like peptide-1 receptor agonists (GLP-1RA). GLP-1RA are known to reduce the stroke risk. Data on SGLT-2i effect on the brain, in conditions of both acute and chronic cerebrovascular disorders, are less complete. The aim of our study was to evaluate the effect of h...

Background and Aim: One of the greatest problem in pregnancy, complicated by diabetes is screening and appropriate care for women, whose diabetes is manifested during pregnancy. The study is aimed at gathering epidemiological data on gestational diabetes mellitus (GDM) and evaluating the of appropriate therapy in this condition.Materials and Methods: Screening for GDM was carried out in – 692 pregnant women. GDM was observed in 3.3% (22 women) and i...

Background: It is generally believed that glycemic targets in diabetic pregnancies should mimic those found in normal pregnancies.Aim: The aim of the present work was to reveal how glycemia indices in pregnant patients with type 1 diabetes mellitus (T1DM), their infants’ birth weight (IBW).Methods: Totally, 128 pregnant women with T1DM were enrolled in the study (mean age – 26±7 yrs; diabetes duration – 10.2&#17...

Background and aimsAlthough bone fracture risk increases in DM, bone mineral density does not completely reflect bone fragility. It is important to explore other methods of osteoporotic fracture risk evaluation. Nowadays bone turnover markers (BTM) investigation is not widely used in clinical practice. On the other hand, the action of some glucose-lowering drugs on bone remodeling is not completely explored. The aim of this study was to investigate and t...

Background:Myocardial infarction (MI) is one of the leading causes of mortality in patients with type 2 diabetes mellitus (DM), therefore it is essential to give preference to a glucose-lowering drug having most prominent cardioprotective properties. Sodium-glucose co-transporter-2 inhibitors (SGLT-2i) have demonstrated an ability to decrease heart failure manifestations, cardiovascular death frequency not having a certain influence on MI occurrence. On ...