Searchable abstracts of presentations at key conferences in endocrinology

ea0081ep881 | Reproductive and Developmental Endocrinology | ECE2022

Noonan Syndrome, Dandy-Walker variant and delayed puberty- a rare association

Lavrador Mariana , Fadiga Lu cia , Ferreira Mafalda Martins , Barros Lui sa , Paiva Isabel

Introduction: The Dandy-Walker complex (DW) comprises a rare intracranial malformation of the posterior fossa and multiple organ anomalies. The association with endocrine pathology is rare - described in isolated cases (Kallman syndrome, primary hypothyroidism (PH) and central precocious puberty). Noonan syndrome (NS) is a genetic disease usually diagnosed at birth, with variable phenotype. Most cases have AD transmission, with the PTPN11 gene mutation responsible for 50%....

ea0014eje1biog | European Journal of Endocrinology Prize Lecture | ECE2007

European Journal of Endocrinology Prize Lecture

Walker Brian

Brian Walker, UK-. AbstractBrian Walker is Professor of Endocrinology at the University of Edinburgh in Scotland where he is administrative head of a 60-strong multidisciplinary research group in the Centre for Cardiovascular Science.He graduated in medicine in Edinburgh in 1986 and completed his clinical training in Glasgow and Edinburgh. Since 1996 he has practised as an honorary consultant i...

ea0013s7biog | Society for Endocrinology Medal Lecture | SFEBES2007

Society for Endocrinology Medal Lecture

Walker Brian

Brian Walker, University of Edinburgh, Edinburgh, United Kingdom. AbstractBrian Walker is Professor of Endocrinology at the University of Edinburgh, where he is administrative head of a 60-strong multidisciplinary research group in the Centre for Cardiovascular Science.He graduated in medicine in Edinburgh in 1986 and completed his clinical training in Glasgow and Edinburgh. Since 1996 he has pra...

ea0011s90 | Contrasting practices in European endocrinology | ECE2006

New endocrinology medicines: when are they good value?

Walker A

Health care payers (governments or insurance plans) are increasingly challenging new health services, including medicines, to prove their value and several European countries have established agencies to help with this task. The example of NICE in England is one example but the Scottish Medicines Consortium (SMC) offers another.In its first four years the SMC has considered 14 endocrinology products, accepting eleven for use (79%). Manufacturers submit e...

ea0005s27 | Prolactin: Novel Aspects | BES2003

PRL and its antagonist: The yin and yang of growth versus differentiation

Walker A

PRL has long been recognized as a hormone that regulates both cell proliferation and differentiation in the mammary gland. Current theory proposes that it is the coexisting steroidal environment which dictates whether PRL is mainly proliferative, as it is during pregnancy, or mainly differentiative, as it is during lactation. While major changes in the steroidal environment may contribute to a shift in response by the mammary gland, other tissues which show both responses to P...

ea0042p16 | (1) | Androgens2016

Identification of protein kinases involved in AR transcriptional regulation in prostate cancer

Walker Scott , Banks Peter , Robson Craig , Coffey Kelly

Phosphorylation of the Androgen Receptor (AR), has been shown to play an important role in directly modulating AR activity. However, the full extent of which protein kinases are involved in the regulation of the AR remains unknown. In order to address which kinases are important in the regulation of AR activity in both androgen sensitive and independent prostate cancer (PCa), a comprehensive siRNA kinome screen was performed. AR transcriptional regulation was evaluated using a...

ea0066pens1.1 | (1) | BSPED2019

The evolving role of the children’s endocrine nurse specialist

Walker Jenny

This is a brief reflection on how the role of the children’s endocrine nurse specialist has evolved over the past 24 years and discussion around what the next 24 years may look like. What have we achieved; what is there still to do and what are the major challenges for the future? When days are filled with phone calls, clinics, paper/ computer work, supporting colleagues and caring for patients- we often forget what we have actually achieved and how much our roles have de...

ea0044cmw2.1 | Workshop 2: Adrenal insufficiency and CAH | SFEBES2016

Dynamic control of tissue glucocorticoids and its implications for replacement therapy

Walker Brian

Although Endocrinologists have focused for decades on circulating concentrations of cortisol, arguably the important concentrations are those within tissues which are available at corticosteroid receptors. Tissue concentrations are influenced by plasma proteins binding cortisol, by physicochemical characteristics of the steroid, by active transport across cell membranes, and by steroid metabolism within target tissues. Many of these factors vary between individuals, and within...

ea0039en2 | (1) | BSPED2015

Bones at ground level

Walker Elaine

An overview of current understanding of bone biology. Including new innovations in therapy,bone growth and vitamin D metabolism. An update on bone health for the specialist nurse working in paediatric endocrinology....

ea0013s7 | Society for Endocrinology Medal Lecture | SFEBES2007

Cortisol and cardiovascular disease: from cradle to grave

Walker Brian

Similarities between the metabolic syndrome and Cushing’s syndrome, and reversibility of the features of Cushing’s syndrome, suggest that cortisol may contribute to pathophysiology in both conditions and that reducing cortisol action may provide a novel therapeutic approach in metabolic syndrome.There is substantial evidence that circulating cortisol concentrations are higher in people with hypertension and glucose intolerance. The basis for th...