Endocrine Abstracts

Introduction: Charcot neuroartropathy (CN) is a devastating complication of diabetes rapidly leading to irreversible foot deformity when misdiagnosed. Differential diagnosis with foot infections and other foot-related diseases remains challenging.Case: A 58-year-old woman with type 2 diabetes was hospitalised with a red, swollen left leg and high fever. The diagnosis of erysipelas with a neuropathic wound of the first digit as the entry wound was establi...

Polycystic ovary syndrome (PCOS) is a common hormonal disorder characterised by reproductive hormone dysregulation involving luteinising hormone (LH) hypersecretion and hyperandrogenism, as well as reduced fertility, due to ovulatory disturbance. In addition, women with PCOS are also predisposed to metabolic disturbances such as obesity, insulin resistance, and dyslipidemia, with an increased risk of cardiovascular disease and type 2 diabetes. Currently, as the origins of PCOS...

Introduction: The Dandy-Walker complex (DW) comprises a rare intracranial malformation of the posterior fossa and multiple organ anomalies. The association with endocrine pathology is rare - described in isolated cases (Kallman syndrome, primary hypothyroidism (PH) and central precocious puberty). Noonan syndrome (NS) is a genetic disease usually diagnosed at birth, with variable phenotype. Most cases have AD transmission, with the PTPN11 gene mutation responsible for 50%....

Brian Walker, UK-. AbstractBrian Walker is Professor of Endocrinology at the University of Edinburgh in Scotland where he is administrative head of a 60-strong multidisciplinary research group in the Centre for Cardiovascular Science.He graduated in medicine in Edinburgh in 1986 and completed his clinical training in Glasgow and Edinburgh. Since 1996 he has practised as an honorary consultant i...

Brian Walker, University of Edinburgh, Edinburgh, United Kingdom. AbstractBrian Walker is Professor of Endocrinology at the University of Edinburgh, where he is administrative head of a 60-strong multidisciplinary research group in the Centre for Cardiovascular Science.He graduated in medicine in Edinburgh in 1986 and completed his clinical training in Glasgow and Edinburgh. Since 1996 he has pra...

Health care payers (governments or insurance plans) are increasingly challenging new health services, including medicines, to prove their value and several European countries have established agencies to help with this task. The example of NICE in England is one example but the Scottish Medicines Consortium (SMC) offers another.In its first four years the SMC has considered 14 endocrinology products, accepting eleven for use (79%). Manufacturers submit e...

PRL has long been recognized as a hormone that regulates both cell proliferation and differentiation in the mammary gland. Current theory proposes that it is the coexisting steroidal environment which dictates whether PRL is mainly proliferative, as it is during pregnancy, or mainly differentiative, as it is during lactation. While major changes in the steroidal environment may contribute to a shift in response by the mammary gland, other tissues which show both responses to P...

Introduction: Intrahepatic cholestasis of pregnancy (ICP) is characterised by maternal pruritus and raised serum bile acids, and is associated with adverse fetal outcomes (e.g. preterm birth, neonatal unit admission and stillbirth). Maternal metabolic impacts include higher rates of gestational diabetes mellitus, hypertriglyceridaemia and hypercholesterolaemia. Glucose and lipid metabolism are influenced by gut incretin release, and bile acids are ...

Introduction: Intrahepatic cholestasis of pregnancy (ICP) is characterised by maternal pruritus and raised serum bile acids, and is associated with adverse fetal outcomes (e.g. preterm birth, neonatal unit admission and stillbirth). Maternal metabolic impacts include higher rates of gestational diabetes mellitus, hypertriglyceridaemia and hypercholesterolaemia. Glucose and lipid metabolism are influenced by gut incretin release, and bile acids are ...

Background: In men inhibin B is correlated with sperm count, concentration and testicular volume. Anti-müllerian hormone (AMH) is significantly positively correlated with inhibin B and significantly negatively correlated with FSH. Raised FSH is a traditional marker of infertility. Young male cancer patients treated with gonadotoxic agents are at high risk of hypogonadism (HG). The relationship between inhibin B and AMH with serum total testosterone is unclear.<p class...