Endocrine Abstracts

Introduction: Gayet-Wernicke encephalopathy (WE) is a rare neurological disorder, caused by thiamine (vitamin B1) deficiency. We report a case of tertiary adrenal insufficiency revealing Gayet-Wernicke encephalopathy.Case presentation: A 45-year-old women was admitted with abdominal pain, vomiting and weakness. Her medical history was significant for a long-term self-medication with corticosteroids and chronic vomiting. Clinical examination revealed a cu...

Introduction: Wernicke’s encephalopathy, resulting from thiamine deficiency, is a rare but serious neurological complication of bariatric procedures. The diagnosis is still difficult since the classic clinical triad (confusion, ataxia and oculomotor abnormalities) and the typical radiological features (areas of hyperintensity in mammillary bodies, thalamus, periaqueductal and periventricular gray matter) are not always present. Also, thiamine blood tests are not broadly a...

Introduction: Wernicke’s encephalopathy is a rare neurological disorder initially described in alcohol-dependent and malnourished patients. It is characterised by confusion, ataxia and nystagmus. It is caused by thiamine deficiency. We report the case of a patient with hyperemesis gravidarum and hashitoxicosis complicated by Wernicke’s encephalopathy Observation: A 22 year old patient, 1G0P, without any particular pathological history, was admi...

Transient mild hyperthyroidism is fairly common in women with hyperemesis gravidarum, occurring in up to two-thirds of them. It is also a well known fact that pregnant women with severe hyperemesis gravidarum can progress to develop Wernicke’s encephalopathy. Hyperthyroidism, without any other risk factors, has been described to accelerate the process of thiamine depletion as well. This is much less recognised.We describe the case of a 32-year-old P...

Introduction: Gayet Wernicke’s encephalopathy (GWE) is a severe encephalopathy secondary to acute thiamine (vitamin B1) deficiency which may lead to severe sequelae or death if the diagnosis is delayed. We report the first case in the literature of an association between GWE and primary hyperparathyroidism (PHP) in a man.Observation: He was a 57 years old man, with a personal history of hypertension and primary infertility, who presented with incoer...

A 30-year-old Eritrean female presented with a 1 month history of nausea and vomiting, with 15 kg weight loss but no bowel disturbance. Past medical history included an open cholecystectomy. There was no family history of mineral or bone disorders. She denied any prescribed/over-counter medication and abstained from alcohol. Examination revealed marked cachexia (BMI 16.1 kg/m2). ECG revealed ST depression and T wave inversion.Investigations in...

Introduction: Wernicke Encephalopathy (WE) is an acute neurologic disorder caused by thiamine deficiency. It is characterized by the classic triad of encephalopathy, gait ataxia and oculomotor dysfunction. It occurs in the setting of poor nutrition caused by lack of dietary intake or malabsorption. Since both of them can happen in patients that underwent bariatric surgery it is of utmost importance to prevent, recognize and treat this severe complication.<p class="abstext"...

Background & Aims: NutriAct is a 36-month randomized controlled multi-center trial aiming to analyze the effects of a dietary pattern focusing on a high-protein and high-unsaturated fatty acids (UFA) intake on healthy aging. We aimed to explore changes in intake of macronutrients and determine factors associated with a successful modulation of dietary pattern after 36 months in elderly community dwelling participants.Methods: 502 participants were ra...

Background: Pheochromocytomas and catecholamine-secreting paragangliomas (PPGL) are rare catecholamine-producing tumors. Due to the rarity, limited data on prognosis exists and data are mainly from tertiary centers with potential referral bias. Here, we present population-based mortality data over an observation period of 40 years.Materials and methods: We identified a cohort of 198 PPGL patients diagnosed 1 January 1977 to 31 December 2016 in North and ...

BackgroundLong-term effects of an increase in unsaturated fatty acids and protein on changes in intrahepatocellular lipids (IHL) are still unclear. We aimed to explore the impact of changes in individual macronutrients on IHL changes within the NutriAct intervention trial over 12 months in middle-aged and elderly subjects (50–80 yrs) at risk for age-related diseases.DesignIn the NutriAct randomized contr...