Searchable abstracts of presentations at key conferences in endocrinology

ea0026p535 | Bone/calcium/Vitamin D | ECE2011

Prevalence of metabolic bone disease in Wilson’s disease (WD) patients

Teixeira Sofia , Domingos Joana , Carvalho Rui , Miranda Helena Pessegueiro , Magalhaes Marina

Background: Skeletal changes including demineralization have been reported in WD. The exact mechanism originating these changes isn’t completely understood but some authors have proposed a link to vitamin D (VitD) metabolism.Aim: To investigate the prevalence of demineralization in a cohort of WD patients and correlate it with VitD status and severity of hepatic and neurological involvement.Methods: Thirty-five patients (17 ma...

ea0077p181 | Metabolism, Obesity and Diabetes | SFEBES2021

Bio informatic Analysis Reveals Hundreds of Differentially-Expressed lncRNAs with Potential Roles in β-Cell Proliferation

Wilson Maya , Pullen Timothy

Background and Aims: As a loss of functional β-cell mass contributes to type 2 diabetes (T2D), increasing β-cell proliferation is a potential therapy to compensate for impaired insulin output. Long non-coding RNAs (lncRNAs) regulate several key β-cell genes and the presence of more than 1100 human β-cell enriched lncRNAs raises the potential for wider roles. Here we have identified 5 independent studies that capture the β-cell transcriptome during adap...

ea0070aep1039 | Hot topics (including COVID-19) | ECE2020

Impact of obesity on types of myocardial infarction

Gin Julian , Wilson Andrew

Introduction: Obesity is an independent risk factor of coronary artery disease, and it has also been shown to be associated with increased survival in some instances such as myocardial infarction – dubbed the ‘Obesity Paradox’. However, there is a paucity of studies identifying the type of myocardial infarction – non-ST-segment elevation MI (NSTEMI) or ST-segment MI (STEMI) – that may be differentially prevalant according to BMI (body mass index) ...

ea0077p16 | Adrenal and Cardiovascular | SFEBES2021

Implications of UK adrenalectomy guidelines for remote and rural patients in the Highlands of Scotland: An audit of adrenalectomy practice in a single UK Centre

Wood Kirsty , Macfarlane David , Wilson Ian

Introduction: National audits suggest significant variation in experience of individual surgeons performing adrenalectomies. A 2016 cross specialty consensus statement recommended that adrenal surgeons perform a minimum of six adrenalectomies per year given improved outcomes with higher volume surgeons. Patients in the Scottish Highlands requiring adrenalectomy are referred to a single Consultant Urologist with a specialist interest in retroperitoneal surgery based in Raigmore...

ea0081p747 | Thyroid | ECE2022

Outcomes of incidental thyroid nodules identified during imaging for primary hyperparathyroidism: a retrospective observational clinical study

Yousuf Quratulain , Wilson Paul , Varadhan Laks

Introduction: Pre-operative localization of parathyroid adenoma is generally done by two localization studies: ultrasonography (US) and parathyroid scintigraphy using 99 m-techentium sestamibi SPECT with CT (Tc-MIBI SPECT/CT), which also report on Incidental thyroid nodules. The aim of our retrospective study was to determine the incidence, characteristics and outcomes of these incidental thyroid findings during parathyroid imaging.Method: A database of ...

ea0066p18 | Diabetes 1 | BSPED2019

Botswana children and young people with diabetes partnership project

Nelson Frances , Wilson Kate , Williams Matthew

Introduction: In April 2019 a team of healthcare professionals took a group of young people with type 1 Diabetes to Botswana for a healthcare partnership project with Diabetes Botswana. The trip included a joint diabetes youth camp and the delivery of Botswana’s first ever Diabetes Educational Symposium.Objectives: The primary aim of the project was to provide a reciprocal learning experience for the management of type 1 diabetes for healthcare prof...

ea0036P29 | (1) | BSPED2014

Does continuous subcutaneous insulin infusion therapy improve diabetic control in a district general hospital population?

Lynch Geraldine , Wilson Josephine , D'Cruz Sonali

Background: Type 1 diabetes mellitus is an autoimmune condition resulting in insulin deficiency, causing both long and short term complications. The Diabetes Control and Complications Trial (DCCT) demonstrated that tight glycaemic control and consequent lower HbA1c values reduced the risk of long-term complications. This can be achieved using multiple daily injections (MDI) or newer continuous subcutaneous insulin infusion (CSII) therapy. This is recommended by NICE for those ...

ea0034p159 | Growth and development | SFEBES2014

Identification and characterisation of human foetal adrenocortical progenitor cells

Sampson Jessica , Wilson David , O'Kelly Ita

The human foetal adrenal gland (HFA) comprises of two distinct zones; the foetal zone (FZ) and the definitive zone (DZ). The subcapsular DZ has been proposed to contain a population of adrenocortical progenitors that migrate centripetally to populate the FZ. Rodent studies have identified sonic hedgehog (SHH) signalling in a subcapsular non-steroidogenic progenitor population and its disruption during development causes adrenal hypoplasia. The involvement of SHH in the human f...

ea0032p289 | Clinical case reports - Thyroid / Others | ECE2013

Insulin autoimmune syndrome, IAS (Hirata disease) case report

Chockalingam Ganesh , Wilson Dennis , Clifton-Bligh Roderick

Introduction: Insulin autoimmune syndrome was first described in 1973 by Hirata, characterised by recurrent spontaneous postprandial hypoglycaemia. Serum insulin is extremely high with elevated insulin autoantibodies. More than 170 cases reported worldwide. We report the first case of IAS in Australia.Case report: Eighty one-year old Argentinean woman with 3 month history of intermittent, late postprandial diaphoresis, tremors, palpitations, dizziness an...

ea0029n15 | (1) | ICEECE2012

Diabetic foot in jordan: a qualitative content analysis of self-treated problems

Abu-Qamar Ma'en Zaid , Wilson Anne

Diabetes is a chronic condition that predisposes to a wide range of foot problems that potentially end with ulcer formation. The purpose of this manuscript is to report 68 participants’ diabetic foot problems self-treated with complementary therapies. Participants were recruited from nine healthcare facilities in Jordan and interviewed via survey. Their responses to an individual question seeking information about complementary therapy usage was analysed using content ana...