Searchable abstracts of presentations at key conferences in endocrinology

ea0042oc6 | (1) | Androgens2016

Transgender: biological model for steroid action

Wildt Ludwig , Winkler-Crepaz Katharina , Boettcher Bettina

Transgender patients are treated by down-regulation oft he pituitary gland and the gonads with GnRH- analogues and the opposite male or female sex steroids, followed by gonadectomy. After gonadectomy, the GnRH analogue is discontinued while the treatment with sex steroids (estrogen or testosterone) is continued. This offers the unique possibility to study the effects of sex steroids on bone density, metabolism, and other regulatory systems in the opposite sex. We present data ...

ea0020p681 | Signal Transduction | ECE2009

A newly identified loss-of-function mutation in helix 5 reveals new insights into signalling mechanisms of the thyrotropin receptor

Winkler Franziska , Kleinau Gunnar , Gruters Annette , Krude Heiko , Krause Gerd , Biebermann Heike

In two siblings suffering from congenital hypothyroidism we identified a homozygous missence mutation Ala579Val in transmembrane helix 5 of the thyrotropin receptor (TSHR) gene which motivated us to investigate molecular details of this mutation.We were interested, firstly, in the functional effects regarding signal transduction and, secondly, in the particular structural properties of the wild type receptor and the Ala579Val mutant. The aim was to gain ...

ea0011p556 | Growth and development | ECE2006

Adrenal (interrenal) development in the zebrafish

To TT , Hahner S , Rohr K , Nica G , Hammerschmidt M , Winkler C , Allolio B

To clarify the role of the pituitary in zebrafish interrenal development we investigated wildtype (wt) zebrafish and 3 pituitary mutants: aal (with lactotrophes only), and pit1 (with corticotrophes only), fgf3-lia (lacking all adenohypophyseal cell types) and in MC2R knockdown embryos (MC2R morphants).The interrenal primordium (IP) is detectable at 22hpf (hours post fertilization) as bilateral clusters of ff1b expressing cells which fuse to one domain at...

ea0094oc2.4 | Endocrine Cancer and Late Effects | SFEBES2023

Communication between peri-prostatic adipocytes and epithelial cells drives prostate cancer aggressivity in obese men

Grunberg Nil , Qian Jiani , Tam Joseph , Lorentzen Marc , Winkler Mathias , Ahmed Hashim , Bevan Charlotte , Fletcher Claire

Prostate Cancer (PC) affects 1-in-6 men in the UK, and obesity 1-in-3, with rates of both increasing. High-fat diet is linked with increased risk of PC death, and volume of peri-prostatic adipose tissue (PPAT) is associated with increased risk of lethal PC/reduced therapy response. Despite this, molecular mechanisms underpinning obesity-driven PC remain poorly-understood. This is important since weight-gain and central obesity are major side-effects of PC trea...

ea0016p290 | Endocrine tumours | ECE2008

Down-regulation of ENO1/MBP-1 gene products by retinoic acid (RA) causes decreased proliferation of the follicular thyroid carcinoma cell line FTC-133

Trojanowicz Bogusz , Winkler Anja , Hammje Kathrin , Chen Zhouxun , Sekulla Carsten , Glanz Dagobert , Schmutzler Cornelia , Mentrup Birgit , Hombach-Klonisch Sabine , Klonisch Thomas , Finke Rainer , Kohrle Josef , Dralle Henning , Hoang-Vu Cuong

Retinoic acid (RA) acts as an anti-proliferative and re-differentiation agent in the therapy of thyroid carcinoma but the molecular mechanisms by which RA mediates these effects are not well understood. We have investigated the effect of RA on the production and post-translational modification of the two ENO1 transcriptional products in the human follicular thyroid carcinoma cell line FTC-133. The single ENO1 transcript encodes a 48 kDa ENO1 with its unique N-terminal enolase ...