Endocrine Abstracts

Delayed wound healing (WH), characterized by ischemia, is exacerbated by glucocorticoid (GC) excess. Local GC availability is regulated by the enzyme 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) which generates the GC cortisol from inactive cortisone. We previously reported improved WH in 11β-HSD1-null mice but regulation of 11β-HSD1 by hypoxia in human skin remains unknown. Primary human dermal fibroblasts (HDF, biological n=3), were treated...

Chronic wounds contribute significantly to patient morbidity, mortality and associated healthcare costs. Glucocorticoid (GC) excess and hypoxia are both associated with impaired wound healing (WH) outcomes. The cyclooxygerase 2 (COX2) pathway is an integral component of inflammation and WH. Locally, GC availability is regulated by the enzyme 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) which generates cortisol from inactive cortisone. Although we recently demon...

Objectives: The clinical significance of antithyroglobulin antibody (TgAb) levels verified concomitantly with undetectable thyroglobulin (Tg) during the follow-up of patients with differentiated thyroid carcinoma remains under debate. The present study aimed to evaluate the presence and prognostic predictive value of TgAb during the follow-up of patients with differentiated thyroid carcinoma.Methods: A retrospective cohort study was performed by reviewin...

Objective: Cushing’s disease (CD) may cause atrophy of different regions of the human brain, mostly affecting the hippocampus and the cerebellum. This study evaluates the use of 3-T MRI of newly diagnosed patients with CD to detect atrophic degeneration with voxel-based volumetry.Methods: Subjects with newly diagnosed, untreated CD were included and underwent 3-T MRI. Images were analyzed using a voxelwise statistical test to detect reduction of bra...

Introduction: thyroid carcinoma is an uncommon malignancy, but it’s incidence appears to be increasing slowly (female 2–3.8/100.000 - male 1.2–2.6/100.000). This is the most common malignant endocrine tumour, represents about 1% of all malignancies. The majority of these patients females, mostly between the age of 30–60. The main differentiated histological types are papillary and follicular. The options of the treatment are surgical removal (mainly total),...

Background: Radiotherapy (RT) with or without chemotherapy is a common treatment for head and neck squamous cell carcinoma (HNSCC) patients and it can cause adverse effects, including dysfunctions of thyroid. The aim of this study was to identify thyroid dysfunction among patients submitted to external RT for treatment of HNSCC, with serial evaluation of thyroid function.Material and methods: This is a retrospective longitudinal study of the follow-up of...

Introduction: Knowing mental representations about the phenomenon of illness and medical care allows the clinical team to have better emotional handling of their patients, with gains in greater adherence to treatments. Graves’ Ophthalmopathy is an inflammatory disease with primary involvement of the extraocular muscles and orbit, being the most frequent extrathyroidal manifestation of Graves’ disease (GD). Many patients have psychological status changes even after su...

The history of a female patient is demonstrated as an example of diagnostic and therapeutical pitfalls in acromegaly. The patient was first operated on a pituitary macroadenoma at her age of 21. Prior to surgery, serum prolactin was found moderately elevated and the patient was raromenorrhoic, without galactorrhea. Soon recurrence of the tumour was trialed with bromocriptine medication, however, without any inhibitory effect on the process. The patient underwent a second neuro...

Type 1 cannabinoid receptor (CB1) is the principal receptor for endocannabinoids in the brain which mainly occurs in preterminal/terminal axons and mediates retrograde neuronal signaling mechanisms. A large body of physiological and electrophysiological evidence indicates the critical role of CB1 in the regulation of hypothalamic functions. Conversely, the distribution of CB1-containing axons in the hypothalamus is essentially unknown. Therefore, we have analyzed the distribut...

Background: Cushing’s syndrome results from chronic exposure to excessive levels of glucocorticoids (GC). The clinical manifestations associated with hypercortisolaemia are variable and differ widely in severity, including hypertension, apparent obesity and metabolic aberrations such as diabetes, dyslipidaemia, ultimately leading to changes similar to the metabolic syndrome. We hypothesised that GC might influence the expression of the genes involved in lipogenesis and gl...