Searchable abstracts of presentations at key conferences in endocrinology

ea0005oc2 | Reproduction and Development | BES2003

A functional polymorphism in the extrapituitary prolactin promoter has opposing effects on prolactin gene expression in T-lymphocytes and endometrial stromal cells but is not associated with unexplained recurrent miscarriages

Stevens A , Brintnell W , Worthington J , Zoumpoulidou G , Jivraj S , Regan L , Brosens J , Davis J

Prolactin is expressed in lymphoid cells and differentiating (decidualised) endometrial stromal cells (ESCs) under the control of an alternative upstream promoter, distinct from the pituitary-specific promoter. Local prolactin action may have immunomodulatory effects. Th1/Th2 imbalance may be an important cause of habitual abortions in man but the mechanism is unknown. Recently, we characterised a G/T SNP at position -1149 that altered prolactin production by lymphocytes, and ...

ea0095p132 | Miscellaneous/other 2 | BSPED2023

Initial accuracy and family experience evaluation of the Dexcom G7 continuous glucose monitor for hypoglycaemia due to hyperinsulinism

Worth Chris , Worthington Sarah , Ahmad Sumera , O'Shea Elaine , Salomon-Estebanez Maria , Banerjee Indraneel

Background: For children with congenital hyperinsulinism (HI), detection and avoidance of hypoglycaemia is the cornerstone of clinical management and poses significant demands on families. Standard of care remains intermittent fingerprick monitoring but the lack of predictive information has resulted in continuous glucose monitoring (CGM) increasing in popularity. Accuracy is suboptimal in this group and family feedback identifies various barriers to use. We a...

ea0085oc5.9 | Oral Communications 5 | BSPED2022

Evaluation of a low postnatal hypoglycaemia threshold

Worth Chris , Ramya Gokul Pon , R Hashim , H Porte , Worthington Sarah , Dunne Mark , Estebanez Maria Salomon , A Mahaveer , Banerjee Indi

Background and objective: Neonatal hypoglycemia is common and frequently self-resolving, although rare due to congenital hyperinsulinism are associated with high risk of brain injury. The time period for neonatal hypoglycemia has been described in several studies. It is unknown if low hypoglycemia thresholds (<2.0 mmol/l) lead to missed cases of persistent hypoglycaemia. We aimed to ascertain if lower hypoglycemia threshold risked missing persistent forms of hypoglycemia i...

ea0011p413 | Diabetes, metabolism and cardiovascular | ECE2006

Polymorphisms in insulin-like growth factor binding protein-1 (IGFBP-1) are associated with altered circulating IGF-I and lower body mass index in type-2 diabetes mellitus

Heald AH , Stephens RH , McElduff P , Kaushal K , Siddals K , New JP , Worthington J , Ollier WE , Gibson JM

Introduction: Dysregulation of the insulin-like Growth Factor (IGF) system and particularly IGF-I and IGF binding protein-1 (IGFBP-1) has been implicated in the pathogenesis of obesity, diabetes mellitus and its complications such as cardiovascular disease and nephropathy, but relatively little is known about the genomics of the IGF system in health and disease.Methods: Six single nucleotide polymorphisms (SNPs) were genotyped in the IGFBP-1 gene, in a r...

ea0011p414 | Diabetes, metabolism and cardiovascular | ECE2006

Polymorphisms in insulin-like growth factor binding protein-1 (IGFBP-1) are associated with increased type-2 diabetes mellitus prevalence

Heald AH , Stephens RH , McElduff P , Kaushal K , New JP , Worthington J , Ollier WE , Pendleton N , Horan M , Payton A , Gibson JM

Introduction: Dysregulation of the Insulin-like Growth Factor (IGF) system and particularly IGF-I and IGF-binding protein 1 (IGFBP-1) has been implicated in the aetiopathogenesis of obesity, diabetes mellitus and such complications such as cardiovascular disease and nephropathy. However, relatively little is known about the genomics of the IGF system in health and disease.Methods: Six single nucleotide polymorphisms (SNPs) were genotyped in the IGFBP1...