Endocrine Abstracts

Soy and red clover extracts contain high concentrations of isoflavones, particularly of genistein, which bind to both estrogen receptors α and ß (ERα and ERß). Lifelong nutrition rich in soy proteins or soy protein isolates appear to exert positive effects on certain health aspects including the development of mammary cancer but the beneficial effects become questionable when soy/isoflavone-rich nutrition starts in later adult life. Stimulatory effects on m...

The endocrine active compound 4-methylbenzylidene-camphor (4-MBC) is frequently used as an UV absorber in sunscreens and various skin care products. Though 4-MBC is weakly estrogenic in the reproductive system of fishes and rodents it shows strong anti-osteoporotic effects. Furthermore, different studies show percutanous absorption of 4-MBC after dermal administration resulting in identical biotransformation in humans and rats. Female Sprague-Dawley rats received five concentr...

UV filters are produced in high amounts for multiple uses. Their main application is in sun lotions for skin protection against accelerated ageing or cancer, but they are also found in many other cosmetics or in plastic materials to prevent their radiation-induced damage. Regardless of these protective properties, UV filters seem to interfere with both the reproductive and the thyroid endocrine axis. We here screened for effects of the UV filter benzophenone 2 (BP2) on thyroid...

4-methylbenzylidene-camphor (4MBC) is an endocrine active compound used as an UV absorber in sunscreens and other cosmetics such as anti-aging lotions and day care products. 4MBC shows weak estrogenic effects on the reproductive system but strong anti-osteoporotic effects after chronic application (Seidlova-Wuttke D et al. 2005 Toxicol Appl Pharmacol. 24:in press). Additionally, 4MBC can be resorbed through the skin (Janjua NR et al. 2004 J Invest Dermatol...