Endocrine Abstracts

Introduction: Both endothelial dysfunction and albuminuria have been shown to be related to cardiovascular risk. We aimed to investigate relations between endothelial dysfunction, albuminuria and frequency of the microvascular complication in type 2 diabetic patients.Method: Forty type 2 diabetic patients (24 microalbuminuria and 16 macroalbuminuria) with a mean age of 57.2±10.8 years and 25 healthy control subjects with a mean age of 54.1±9.6 ...

Introduction: Alterations in glucose homeostasis and diabetes mellitus (DM) are the most common metabolic comorbidities in acromegaly. DM has been reported in 16–56% of patients with acromegaly. It is estimated that 20% of patients with acromegaly have developed DM before the formal diagnosis of acromegaly. We report a case of a patient with acromegaly secondary to a pituitary macroadenoma who presented with diabetes.Case report: A 47- year-old fema...

Introduction: Although the thyroid isthmus seems like a structure that connects bilateral lobes, it is an undiscovered area that needs to be explored. Currently, the data is evolving that the increase in the risk of malignancy is higher in the isthmic nodules, and extrathyroidal extensions and lymph node metastases are more common in isthmic-derived malignant thyroid nodules. Therefore, we aimed to compare the malignancy rate of isthmic and lobar nodules, the ultrasonographic ...

Introduction: Subacute thyroiditis (SAT) has been reported after COVID-19 infection and SARS-CoV-2 vaccination. SAT has a mild and self-limiting course. This is the first reported case of thyroid storm following the SARS-CoV-2 vaccineCase: A 32-year-old female patient had mild anterior neck pain, fatigue, tremor 2 weeks after being administered with the second dose of COVID-19 mRNA vaccine BNT162b2 (Pfizer–BioNTech). Initial biochemical investigatio...

In recent years there has been increasing evidence for neuroendocrine dysfunction as a sequel of aneurysmal subarachnoid hemorrhage (SAH). One investigation has assessed pituitary function in SAH-survivors in a longitudinal design 3 and 12 months after the hemorrhage, but nothing is known about the dynamics of the hypothalamo-pituitary axis in the years following the bleeding. We present the data of 5 patients who had sustained aneurysmal SAH and had undergone their first endo...

Objective: Insulin insufficiency which is the result of deficiency of β-cells is the common feature for all types of diabetes. Therefore protection of functional β-cell mass is the keystone of diabetes treatment. Betatrophin, a newly determined hormone, has been identified as a potent stimulator that increases the production and expansion of β-cells in mice. However, very little is known about the physiological role of betatrophin in h...

Introduction: In primary hypothyroidism, the increase in TRH may cause hyperplasia in the pituitary gland. It has been reported that long-standing hypothyroidism might also cause irreversible pituitary damage, which may lead to a deficiency in one or more pituitary hormones. Herein, we report a case with primary autoimmune hypothyroidism causing pituitary enlargement mimicking pituitary macroadenoma and secondary adrenal insufficiency. Case: A 17-year-ol...

Introduction: Giant prolactinomas are rare tumors accounting for 2–16% of all prolactinomas. They may be aggressive and invasive. Rarely, they might not have a suprasellar component and grow downward. Such extension can make it difficult to distinguish pituitary adenoma from other skull base tumors. We present a case that was considered to be chordoma based on clinical and radiological imaging features, but was diagnosed as prolactinoma by pituitary biopsy.<p class="a...

Introduction: Coronavirus disease-19 (COVID-19) pandemic renders high morbidity and mortality. Glucocorticoid excess is characterized by increased susceptibility to infections due to impairment of the innate and adaptive immune system. Manifestations of Cushing disease (CD) including diabetes mellitus (DM), hypertension, and obesity are risk factors for severe COVID-19 disease. We present three CD patients with different clinical courses of COVID-19. The patients’ general...