Searchable abstracts of presentations at key conferences in endocrinology

ea0090ep131 | Calcium and Bone | ECE2023

Hypercalcemic hyperparathyroidism after bariatric surgery–primary or tertiary? Case report

Zajickova Katerina

Bariatric surgery significantly reduces obesity-related comorbidities. Secondary hyperparathyroidism (SHPT), due to calcium malabsorption and vitamin D deficiency, has been frequently reported, however, in patients after bariatric surgery. Whether chronic SHPT after bariatric surgery could ultimately evolve into tertiary hyperparathyroidism has not been clarified. Here, we report a 59-old-woman who presented with osteoporosis (T score at the lumbar spine -4.1 and T score at th...

ea0049ep326 | Clinical case reports - Thyroid/Others | ECE2017

Equivocal preoperative imaging including 18F-fluorocholine PET-CT in primary hyperparathyroidism and nodular thyroid disease – case report

Zajickova Katerina

66-year old woman came first for an evaluation of nodular thyroid disease. Primary hyperparathyroidism (PHPT) was incidentally diagnosed during the entrance lab test with total calcium 2.62 mmol/l and PTH 93 ng/l. Serum creatinine was normal and 25 OH vitamin D was 97 nmol/l. Dual-energy X-ray absorptiometry was carried out and revealed osteoporosis at lumbar spine. Moreover, there were two low-trauma fractures in a recent patient history. Although hypercalcemia was mild, the ...

ea0056p240 | Calcium & Vitamin D metabolism | ECE2018

Thyroid oncocytes may complicate 18F-fluorocholine PET-CT localization of parathyroid adenomas in primary hyperparathyroidism

Zajickova Katerina

18F-fluorocholine positron emission tomography/X-ray computed tomography (PET-CT) was carried out in our patients with primary hyperparathyroidism (PHPT) and inconclusive preoperative neck ultrasound and 99Tc-sestaMIBI scintigraphy to localize abnormal parathyroid glands before surgery. The results were retrospectively evaluated and compared to postoperative histopathological findings. A total of 9 patients (1 man, 8 women) with sporadic PHPT was enrolled...

ea0063p494 | Calcium and Bone 2 | ECE2019

Multiglandular parathyroid disease in patients with primary hyperparathyroidism and inconclusive conventional imaging

Zajickova Katerina , Bendlova Bela

Abstract: The incidence of multiglandular parathyroid disease (MGD) varies in the range 7–33%. Negative preoperative imaging is a strong predictor of MGD in patients with primary hyperparathyroidism (PHPT). We retrospectively evaluated a cohort of 13 patients with PHPT and inconclusive MIBI scintigraphy and/or neck ultrasound (mean age 64 years, total calcium 2.74 mmol/l and parathyroid hormone (PTH) 114 ng/l). All subjects subsequently underwent additional imaging with f...

ea0073aep100 | Calcium and Bone | ECE2021

Denosumab rebound effect associated with breast cancer recurrence – a coincidence? Case report

Zajickova Katerina , Kasalicky Petr

Denosumab discontinuation leads to loss of bone mineral density (BMD) achieved with treatment and in some patients to multiple vertebral fractures (VFx). Beyond bone, antiresorptive agents such as denosumab may affect breast cancer biology. We report a 69-year-old woman treated with the aromatase inhibitor anastrazole for breast cancer who suffered from five spontaneous vertebral fractures after denosumab cessation. Initially, she received four years of ibandronate followed by...

ea0011p575 | Neuroendocrinology and behaviour | ECE2006

Association between the LRP5 gene and serum post-menopausal follicle stimulating hormone levels

Zofkova I , Zajickova K , Hill M

The LRP5 gene is believed to be primarily associated with bone metabolism via Wnt signalling. The latter pathway, however, seems to control various other systems outside the skeleton. We identified the C/T (c.4037:A1330V) polymorphism in the LRP5 gene using a restriction analysis of the PCR product in a cohort of 165 white untreated pre-and post-menopausal women. In a subset of 84 post-menopausal women we analysed the association between the LRP5 genotype and circulatin...

ea0081p470 | Thyroid | ECE2022

McCune-Albright syndrome diagnosed in adulthood with GNAS mutation-related hyperthyroidism and elevated anti-TPO antibodies. Case report.

Zajickova Katerina , Sykorova Vlasta , Mastnikova Karolina , Vcelak Josef

McCune-Albright syndrome (MAS) is a rare mosaic disorder caused by a postzygotic activating mutation in the GNAS gene encoding the G protein alpha subunit. Although clinical manifestations may be heterogeneous, MAS is often characterized by the triad of fibrous dysplasia, café-au-lait skin pigmentations and hyperfunctioning endocrinopathy. We report here a 58-year old woman who presented for evaluation of hyperthyroidism, associated with nodular thyroid disease and elevat...

ea0070aep127 | Bone and Calcium | ECE2020

Familial hypocalciuric hypercalcemia in a young man: Grey zones of the differential diagnosis in 10-year clinical follow up

Zajickova Katerina , Moravcova Jitka , Včelák Josef

Herein, we report currently a 39-year old male with a 13-year history of asymptomatic hypercalcemia (mean 2.88 mmol/l; reference range 2.15–2.55 mmol/l) and mildly elevated parathyroid hormone (mean 68.7 ng/l; reference range 15–65 ng/l). Initially, in years 2007–2010 his laboratory picture was compatible with the diagnosis of Familial hypocalciuric hypercalcemia (FHH) with calcium-to-creatinine clearance ratio (Ca/Cr) between 0.008–0.009.Genetic testin...

ea0016p645 | Reproduction | ECE2008

Serum osteoprotegerin in polycystic ovary syndrome

Zajickova Katerina , Hill Martin , Dvorakova Katerina , Stanicka Sona , Vondra Karel , Vrbikova Jana

Osteoprotegerin (OPG) is a potent inhibitor of osteoclastic bone resorption. Besides osteoblasts, OPG is expressed by both endothelial and vascular smooth muscle cells. Moreover, elevated serum OPG has been found in conditions associated with insulin resistance such as obesity, diabetes and/or Cushing syndrome.The aim of the present study was to investigate the relationship between serum OPG and insulin resistance in women with polycystic ovary syndrome ...

ea0016oc4.7 | Bone and adrenal | ECE2008

Molecular analysis of the calcium sensing receptor (CaSR) gene in 40 patients suspected to have familial hypocalciuric hypercalcemia (FHH)

Defrance-Faivre Frederique , Odou Marie-Francoise , Porchet Nicole , Weill Jacques , Guedj Am , Cardot-Bauters Catherine , Wemeau Jean-Louis , Vantyghem Marie-Christine

Neonatal severe hyperparathyroidism (NSHPTH) and FHH, usually defined as a ratio of calcium clearance/creatinin clearance <0.01 with normal kidney function and vitamin D status, are caused by respectively heterozygote and homozygote inactivating mutations of the CaSR gene. The aim of this study was to assess the interest of analyzing CaSR in hypercalcalcemic subjects suspected to have FHH.Patients and methods: Forty hypercalcaemic subjects fro...