Endocrine Abstracts

Context: Acromegaly is chronic insidious disease caused by excessive GH secretion by pituitary adenoma. This leads to overproduction of IGF1 and serious disseminated concequences.Material: 14 acromegalic subjects with diagnosed insulin dependent diabetes on stable octreotide LAR) treatment. Patients did not meet recent criteria of biochemical controlled disease (mean GH 4.6 ng/ml, mean IGF1 2.2-fold upper normal limit).Methods: Pat...

In acromegaly, an excessive GH secretion by pituitary adenoma, minimal active disease may be defined as slow progression of characteristic signs and symptoms at presence of slightly elevated or normal IGF1 levels and lack of GH suppression after glucose load. Nadir post-glucose GH level defining active disease is under permanent discussion and depends on assessment methods. IGF1 reference range is wide, must be age-adjusted and often is sex-dependent. From mid-00’s excess...

Background: Neurosurgery is treatment of choice in patients with GH-secreting pituitary adenoma. However, in about 50% of cases surgery is ineffective or contraindicated. Long-acting somatostatin analogues are possible, although expensive therapeutic alternative. Generally, 60–70% of patients with active disease responds to such medical treatment.Aim: Aim of this study was to identify factors influencing medical treatment outcome and to determine if...

Background: Insulin resistance leading to glucose intolerance and even diabetes mellitus is common in acromegaly and is partially caused by pathological high concentrations of growth hormone (GH) and somatomedin C (IGF-1). On the other hand, somatostatin analogues, common treatment option, can cause inhibition of insulin secretion and glucose tolerance disturbances.Aim: Of the study was to determine impact of prolonged somatostatin analogues administrati...

Introduction: Generously supported by IPSEN)-->Impaired glucose tolerance and insulin resistance are frequently associated with acromegaly. The aim of this study was to assess the effect of octreotide-LAR treatment on glucose homeostasis in acromegalic patients.Patients and methods: In this prospective study 16 naïve acromegalic patients were studied before and after 3-month therapy of octreotide-LAR (20 m...

Introduction: Impaired glucose tolerance and insulin resistance are frequently associated with acromegaly. The aim of this study was to assess the impact of long-acting somatostatin analog treatment on glucose homeostasis in acromegalic patients.Patients and methods: In this prospective study 16 naïve acromegalic patients (eight females, eight males; aged 51.5±10.9 years) were studied before and after 3-month therapy with long-acting somatostat...

Background: Neuroendocrine tumors awareness is developing. Carcinoid syndrome and hormonal overproduction may be controlled with somatostatin analogues in majority of cases. However, due to unspecific symptomatology in early stages of disease, majority of cases are diagnosed when process is disseminated. Co-morbidities and coexisting diseases are present in most of patients. Bone loss may be accelerated by metastizing tumor, peptides secreted or decreased absorption of vitamin...

Background: Acromegaly is characterized by disabling symptoms and relevant comorbidities. Insulin resistance, leading to glucose intolerance is one of the most important contributory factor to the cardiovascular mortality in acromegaly.Aim: To assess the impairments of glucose homeostasis in acromegalic patients and find association between activity of the disease and the severity of glucose intolerance.Patients and methods: In thi...

Background: TSH-secreting tumors appears as extremely rare cause of hyperthyroidism. Major clinical feature is preserved TSH level in subjects with apparent thyrotoxicosis. Misdiagnosis of primary thyroid hyper function led to mistreatment with anti-thyroid agents. This worsens disease course and outcome. Neurosurgery success rate is limited by large tumor size and extrasellular expansion. Somatostatin plays key role in regulation of TSH secretion. Tumors in most cases express...

Introduction: Impaired glucose tolerance and overt diabetes mellitus are frequently associated with acromegaly. The aim of this study was to find whether these alterations could be reversed after transsphenoidal surgery.Patients and methods: Two hundred and thirty-nine acromegalic patients were studied before and 6–12 months after transsphenoidal surgery. Diagnosis of active acromegaly was established on the basis of widely recognized criteria. In e...