Searchable abstracts of presentations at key conferences in endocrinology

ea0011p693 | Reproduction | ECE2006

Association between polymorphisms within the SUR1/Kir6.2 gene region and polycystic ovary syndrome: a case-control study

Barber TM , Zeggini E , Goh MJ , Webber L , Wass JAH , Franks S , McCarthy MI

Hyperinsulinaemia has an important role in the aetiology of Polycystic Ovary Syndrome (PCOS). Logical candidate genes for the development of PCOS therefore include those genes that influence β-cell insulin secretion such as ABCC8 and KCNJ11 on human chromosome 11. These two genes encode the SUR1 and kir6.2 components of the β-cell kATP channel respectively. To our knowledge, these genes have not been studied in women with PCOS previously.<p class="a...