Endocrine Abstracts

In addition to symptoms of androgen deficiency induced by low serum testosterone concentrations (i.e. classical hypogonadism), also variable phenotypes of androgen insensitivity exist in humans, mainly owing to defective, mutated androgen receptors. A more subtle modulation of androgen effects has been related to the CAG repeat polymorphism (CAGn) in exon 1 of the androgen receptor gene: in vitro, transcription of androgen-dependent target genes is attenuated with incre...

Circumstances of life and food supply have changed in developed countries, resulting in an increasing prevalence of overweight. As a consequence, a complex disorder consisting of visceral obesity, dyslipidemia, insulin resistance and hypertension emerges: the so-called metabolic syndrome leads to the manifestation of diabetes type 2 and cardiovascular disease.In men, testosterone deficiency contributes to the generation of the metabolic syndrome, as demo...

Background: A reliable form of androgen substitution therapy in terms of favorable kinetics and tolerance as well as effective restoration of androgenicity is paramount for hypogonadal men. The i.m. injection of the long-acting ester testosterone undecanoate (TU) offers a convenient modality for testosterone substitution.Methods: We report data from 334 patients (147 with primary (including 38 Klinefelter patients), 100 with secondary hypogonadism and 87...

Background: Testosterone substitution with favourable kinetics and tolerance is important for hypogonadal men. Intramuscular injections of long-acting testosterone undecanoate (TU) offer a convenient modality.Methods: We report data from 281 patients (134 with primary, 88 with secondary hypogonadism and 59 with late-onset (‘mixed’ or ‘metabolic’) hypogonadism aged 15 to 72 years (mean 40±13 years) receiving altogether 4913 intram...

Objective: A reliable form of androgen substitution therapy in terms of favorable kinetics and tolerance as well as effective restoration of androgenicity is paramount in hypogonadal men. A new feasible modality is the intramuscular injection of the long-acting ester testosterone undecanoate (TU).Design: Analysis of safety data accumulated during 101 treatment-years in 66 hypogonadal men receiving altogether 510 injections of 1000 mg TU in 10–14-we...

A reliable form of androgen substitution therapy in terms of favorable kinetics and tolerance as well as effective restoration of androgenicity is paramount in hypogonadal men. A feasible modality is the intramuscular injection of the long-acting ester testosterone undecanoate (TU).We report data from 183 patients (99 with primary, 70 with secondary hypogonadism and 14 with late-onset hypogonadism) aged 15–70 years (mean 37±12 years) receiving ...

Objective: The structure of psychological and somatic complaints of aging male patients in relation to sex hormone patterns and metabolism has not been fully elucidated, especially in regard to late-onset hypogonadism.Methods: We investigated the nature of complaints in 434 consecutive patients aged 50–86 years attending our andrology unit and their association with physical characteristics, life style habits and sex hormone levels.<p class="abs...

Objective: A reliable form of androgen substitution therapy in terms of favorable kinetics and tolerance as well as effective restoration of androgenicity is paramount in hypogonadal men. A feasible modality is the intramuscular injection of the long-acting ester testosterone undecanoate (TU).Design: We report data from 22 patients (15 with primary and 7 with secondary hypogonadism) aged 30 to 65 years (mean 43.8±8 years) who received injections of ...

Testosterone is the hormone that turns males into men and a lack of testosterone, whether of primary or secondary origin, causes hypogonadism characterized by lack of pubertal development or loss of maleness. It was generally assumed that in a man with a normal androgen receptor (AR) androgenicity is regulated by testosterone serum concentrations, slightly modified by SHBG. Only recently it became evident that variations in the AR gene influence testosterone action. Modulation...

Background: Klinefelter syndrome (KS) is the most frequent genetic cause of male infertility. Individuals share the endocrine hallmark of hypergonadotropic hypogonadism, displaying high gonadotropin levels due to deficient testicular function. A single-nucleotide polymorphism (SNP) located within the FSHB promoter region (−211G>T, rs10835638) was recently shown to be associated with reduced serum FSH levels and other reproductive parameters in men. The objec...