Endocrine Abstracts

Introduction: Chronic heart failure (cHF) is an often and unrecognized cause of mortality among people with type 2 diabetes (T2D), more often in elderly. Assessment of cHF comprises of a combination of clinical symptoms, echocardiography and a biomarker N-terminal pro b-type natriuretic peptide. It is underestimated and not treated timely. Sodium-glucose cotransporter 2 (SGLT2) inhibitors are treatment of choice for subjects with T2D and cHF, frequently not initiated in elderl...

Introduction: Monotherapy failure in diabetes mellitus type 2 occurs early in the course of disease. Evaluation of the primary pathogenetic mechanism is of primary importance in choosing the optimal combination therapy.Objectives: To investigate influence of meal stimulated C-peptide levels and HOMA B, as markers of residual insulin secretion on the efficasy of adding metformin to sulphonylurea therapy in subjects with metabolic syndrome, type 2 diabetes...

Introduction: Osteoporosis is a metabolic disease characterised by reduction of the bone mass density and deterioration of architecture of the bone and its strength. Continuous process of modeling and remodeling of bones is regulated by action of numerous circulating hormones. Fracture risk makes osteoporosis clinically important disease.Goal of this study was to examine thyroid dysbalance, parathormone secretion disorder as risk factors for osteoporosis...

Background: In spite of being the most frequent genetic form of male hypogonadism, Klinefelter’s syndrome is not so rarely undiagnosed until adulthood. As the severity of manifestations in Klinefelter’s syndrome is proportional to the number of additional X chromosomes, they seem less severe and aparent in its classic form, with a 47,XXY karyotype than in cases of this syndrome with mosaicism and other variants.Case report: A 25-year-old male w...

Metabolic syndrome (MetS) is known to be associated with low levels of vitamin D. The association of vitamin D in postmenopausal women with MetS and osteoporosis has not been investigated. The aim of our investigation was to assess presence of MetS in postmenopausal women treated for osteoporosis.Metods: Fifty-nive women treated with weekly alendronate, vitamin D (Fosavance 5600, MSD) and calcium for 1 year were evaluated. The following parameters were a...

Background: Adrenal incidentalomas (AI) represent incidentaly discovered adrenal mases, without simptoms or signs suggestive of adrenal pathology, at the time of visualization. It is well-known that overt or subclinical hypercorticism, as well as metabolic syndrome (MetS) harbour increased CV risk.There is still persisting debate on eventual cause-effect relationship of AI with metabolic syndrome MetS or probability of simply more frequent occurance of AI among these patients....

Introduction: Prediabetes carries a risk of diabetes and cardiovascular disease (CVD). Assessment of CVD risk in prediabetes is not as routine, as is assessment of diabetes risk. However, it is not less important. This can be done through conventional SCORE charts and through coronary artery calcium (CAC) score. CAC is examined through multislice CT. Calcifications indicate late-stage subclinical coronary atherosclerosis. The AIM of our study was to assess traditional CVD risk...

Introduction: Coronary artery calcium (CAC) is examined through multislice CT. Calcifications indicate late-stage subclinical coronary atherosclerosis. An association exists between CAC with coronary vascular disease (CVD), Agatston score being an independent predictor of CVD. Including CAC may improve CV risk prediction in addition to conventional risk factors. The AIM of our study was to assess CAC in subjects with prediabetes (preDM) at the beginning of the long term follow...

Oestrogen has very complex effects on the CNS. It protects neurons from noxious effects of β amyloid in vitro, ameliorates the cerebral metabolism and increases the level of acetylcholine in the basal forebrain and hippocampus. Its beneficial impact in Alzheimer disease may be attributed in part to its antioxidant activity. On the other hand, it has been demonstrated that oestrogens may exhibit genotoxic effects, especially at elevated tissue concentrations. Ther...

It is well known that Romani people suffer from respiratory and cardiovascular diseases. The aim of our study was to investigate the prevalence of diabetes in the Romani population in Serbia.Methods: During the period October 2006–May 2008, diabetes association of Serbia performed blood glucose measurements in 11 urban and 8 rural Romani communities in Serbia. Blood glucose values, name, age, presence of diabetes, family history for diabetes, time o...