Endocrine Abstracts

The LRP5 gene is believed to be primarily associated with bone metabolism via Wnt signalling. The latter pathway, however, seems to control various other systems outside the skeleton. We identified the C/T (c.4037:A1330V) polymorphism in the LRP5 gene using a restriction analysis of the PCR product in a cohort of 165 white untreated pre-and post-menopausal women. In a subset of 84 post-menopausal women we analysed the association between the LRP5 genotype and circulatin...

Objective: Skeletal disability pathogenesis is multifactorial. Many studies have proved a negative relation of smoking on calcium-phosphate metabolisms, bone density and quality; however in some other papers these results have not been confirmed. The aim of the study was to monitor the influence of the length of smoking, a number of cigarettes smoked and the age of the first use of cigarettes on the whole-body bone density.Methods: Whole-body densitometr...