Endocrine Abstracts

BACKGROUND: Untreated Adult Growth Hormone Deficiency (AGHD) is associated with reduced bone mineral density (BMD). PTH plays an important role in bone metabolism and reports suggest that bone and renal target cell insensitivity to PTH may contribute to changes in bone turnover in AGHD.OBJECTIVES: To determine the difference in PTH and phosphocalcium metabolism in untreated AGHD patients who have normal and reduced BMD.METHODS: 13 ...

BACKGROUND: Adult growth hormone deficiency (AGHD) is associated with osteoporosis. Growth Hormone replacement (GHR) results in increased bone mineral density (BMD), with greater benefit derived in men. PTH plays an important role in bone metabolism and reports suggest that bone and renal insensitivity to PTH may contribute to changes in bone turnover in AGHD.OBJECTIVES: To determine the gender difference in PTH, phosphocalcium metabolism and bone turnov...

Osteoporosis is considered to be a cardinal feature of Cushing's syndrome with a reported incidence as high as 90%. We conducted a cross-sectional analysis of baseline bone mineral density (BMD) in 21 patients (4 males) aged 19-63 (median, 37) years with untreated Cushing's syndrome. 18 patients had pituitary dependent disease and 3 adrenal adenomas. Dual energy x-ray absorptiometry (DEXA) was used to measure the BMD at the lumbar spine (L1-L4), left femoral neck (LFN) and tot...

Most patients with vitamin D deficiency and osteomalacia have elevated parathyroid levels with normal or low serum calciums .This hyperparathyroidism is described as secondary hyperparathyroidism and resolves with correction of vitamin deficiency. We describe three cases where there was coexistant osteomalacia vitamin D deficiency, elevated parathyroid hormone and hypercalcaemia.Case 1A 40 year old Asian female presented with a six...

Pubertal gynecomastia is associated with an imbalance between estrogen and androgen action on the breast glandular tissue. It is a common condition presenting at 10-12 years and peaking at 13-14 yrs, followed by involution that is usually complete by 17 yrs. Pathologic entities associated with childhood or adolescence gynecomastia are rare.The purpose of this study was to evaluate the bone mineral density (BMD grams/cm2) of children with puber...

Low bone density in women with androgen insensitivity syndrome [AIS] has been attributed to both androgen and oestrogen deficiency. Tall stature in women with AIS has been attributed to the presence of the Y chromosome and to delayed closure of the epiphyses due to relative sex steroid deficiency. In order to gain greater insight into these interactions we have compared bone density and height in four groups of women-27 women with AIS, 15 women with 46XY gonadal dysgenesis, 25...

If calcium intake and absorption are insufficient plasma calcium is maintained but bone loss ensues. The relationship between calcium intake and parathyroid hormone (PTH) levels in serum of 186 women (mean age 62.4 years) with bone mineral density >2.5 SD below the young adult value and 586 age-matched controls with normal bone mineral density was studied.The approximate calcium intake from dairy products was assessed by a simple questionnaire. All 77...