Endocrine Abstracts

Hyperinsulinism has been shown to trigger sympathetic activity experimentally, however the clinical and epidemiologic data on the association of heart rate with hyperinsulinism and insulin resistance. This study was investigated the relationship between insulin resistance and exercise test parameters in unselected consecutive middle aged asymptomatic patients with type II diabetes.Ninety asymptomatic type II diabetics between the ages 36 and 60 without a...

Objective: Vanadium salts have been suggested as a possible therapeutic agent for treating diabetes mellitus in the experimental models of the disease. This study was done to show the correlation between amelioration of diabetic signs and preservation of pancreatic islets in vanadyl sulphate treated streptozotocin - induced diabetic rats.Methods: Diabetes was induced in male Wistar rats by intravenous injection of 40 milligram per kilogram streptozotocin...

Testosterone improves symptoms and exercise capacity in men with heart failure (Pugh et al., Heart, 2003, In Press), and has been demonstrated to lower peripheral vascular resistance in such individuals (Pugh et al., Eur.Heart J. 2003, 24, 909-15), consistent with a systemic vasodilatory activity. The vasodilatory mechanism of testosterone has yet to be investigated in the systemic vasculature. Mesenteric tissue was obtained from male patients (n=14, age=70+2), undergoing gast...

Evidence supports a protective role for testosterone in men with coronary artery disease (CAD) and in the regulation of cytokine function. This study examined the relationship between serum levels of inflammatory cytokines and testosterone in men with CAD. Serum was collected from 69 men (59+1 years) having >75% occlusion of 1 (n=20), 2 (n=18) or 3 (n=31) coronary arteries. Levels of total testosterone (TT), bioavailable testosterone (BT), tumour necrosis factor-alpha (TNFa...

The risk of hypertension is 3-fold increased in women with Turner Syndrome (TS). Coarctation is a known cause of secondary hypertension but for others the aetiology of hypertension is unclear. Studies have demonstrated elevated plasma renin activity (PRA) in girls and young women with TS and hypothesized that the aetiology of hypertension is small vessel renovascular disease. To explore this possibility further blood pressure (BP) and PRA were measured routinely at the Adult T...

Aim: To assess usage of newly available rapid-acting insulin analogues in the antenatal diabetes clinic, and to determine whether introduction of these agents has influenced glycaemic control.Methods: We analysed our diabetes antenatal clinic attendances from April 2002 to June 2003 using the DIABETA 3 database. 290 pregnant women were seen over this period which was divided into three groups: Group I (April to September 2002), Group II (October 2002 to ...

Insulin resistance and/or hyperinsulinemia are risk factors for CVD. Plasma homocysteine is also important risk factor for the development of premature cardiovascular disease (CVD) in type 2 diabetes. The relationship between level of insulin and homocysteine in insulin resistant state is not clear. The aim of our study was to investigate whether plasma homocystein levels are changed by acute hyperinsulinemia and to associate the change of plasma homocysteine with the level of...