ISSN 1470-3947 (print)
ISSN 1479-6848 (online)

Searchable abstracts of presentations at key conferences in endocrinology

Published by BioScientifica
Endocrine Abstracts (2007) 14 P271 
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The relationship between carotid intima-media thickness metabolic and anthropometric parameters in healthy subjects

Hatice Akay1, Deniz Gokalp2, Senay Arikan2, Alpaslan Tuzcu2 & Mithat Bahceci2

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Background and aim: Carotid intima-media thickness (IMT), as assessed by B-mode ultrasound, is a commonly used clinical marker that reflects systemic burden of atherosclerosis and value of IMT at or above 1 mm at any age is associated with a significantly increased risk of myocardial infarction. On the basis of such findings, we aimed to clarify the relationship between carotid intima-media thickness and anthropometric and metabolic parameters in virtually healthy subjects.

Subjects and methods: A total of 117 apparently healthy subjects were included to the study (age 20–68 year, mean age: 43±12, BMI:30.1±7.99 kg/m2). Carotid Intima-media thickness (IMT) was measured with ultrasonography. Subjects were divided into two groups according to their IMT higher than 1 mm (group-1) or not (group-2). Total cholesterol, LDL-cholesterol, triglycerides, Hs-CRP, interleukin-1β, interleukin2, interleukin 6, interleukin 8, Tumour necrosis factor α, BMI, body fat mass with bioelectric impedance and body fat distribution (waist and hip circumference) of two groups were compared with independent t test.

Results: BMI, body fat mass, hip circumference, plasma LDL cholesterol, Hs-CRP levels of group-1 were higher than group-2 (Table 1) Interleukin-1β, interleukin2, interleukin 6, interleukin 8, Tumour necrosis factor α, triglycerides, waist circumference of the two groups were not show any statistically difference.

Conclusions: 1-Carotid intima media thickness are closely related increased BMI, fatmass, hip circumference and LDL-cholesterol levels.

2-Hs-CRP is a useful marker of atherosclerosis.

Group-1 (n=17)Group-2 (n=100)P value
BMI37.6±7.128.7±7.3P=0.0001
Body Fatmass40.7±15.224.9±14.3P=0.001
Hip circumference122±18107±14P=0.0001
Hs-CRP7.23±2.953.67±1.50P=0.008
LDL-cholesterol135.4±29.8108.8±33.2P=0.008

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