Searchable abstracts of presentations at key conferences in endocrinology
Endocrine Abstracts (2007) 14 P271

ECE2007 Poster Presentations (1) (659 abstracts)

The relationship between carotid intima-media thickness metabolic and anthropometric parameters in healthy subjects

Hatice Akay 1 , Deniz Gokalp 2 , Senay Arikan 2 , Alpaslan Tuzcu 2 & Mithat Bahceci 2

1Dicle University School of Medicine Department of Radiology, Diyarbakir, Turkey; 2Dicle University School of Medicine Department of Endocrinology, Diyarbakir, Turkey.

Background and aim: Carotid intima-media thickness (IMT), as assessed by B-mode ultrasound, is a commonly used clinical marker that reflects systemic burden of atherosclerosis and value of IMT at or above 1 mm at any age is associated with a significantly increased risk of myocardial infarction. On the basis of such findings, we aimed to clarify the relationship between carotid intima-media thickness and anthropometric and metabolic parameters in virtually healthy subjects.

Subjects and methods: A total of 117 apparently healthy subjects were included to the study (age 20–68 year, mean age: 43±12, BMI:30.1±7.99 kg/m2). Carotid Intima-media thickness (IMT) was measured with ultrasonography. Subjects were divided into two groups according to their IMT higher than 1 mm (group-1) or not (group-2). Total cholesterol, LDL-cholesterol, triglycerides, Hs-CRP, interleukin-1β, interleukin2, interleukin 6, interleukin 8, Tumour necrosis factor α, BMI, body fat mass with bioelectric impedance and body fat distribution (waist and hip circumference) of two groups were compared with independent t test.

Results: BMI, body fat mass, hip circumference, plasma LDL cholesterol, Hs-CRP levels of group-1 were higher than group-2 (Table 1) Interleukin-1β, interleukin2, interleukin 6, interleukin 8, Tumour necrosis factor α, triglycerides, waist circumference of the two groups were not show any statistically difference.

Conclusions: 1-Carotid intima media thickness are closely related increased BMI, fatmass, hip circumference and LDL-cholesterol levels.

2-Hs-CRP is a useful marker of atherosclerosis.

Group-1 (n=17)Group-2 (n=100)P value
Body Fatmass40.7±15.224.9±14.3P=0.001
Hip circumference122±18107±14P=0.0001

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