Endocrine Abstracts

The mineralocorticoid receptor is a ligand-activated transcription factor involved in renal ion homeostasis and blood pressure control. The MR is also expressed in non-renal targets such as heart, vessels, adipose tissue and immune cells where its role remains to be defined. Pharmacological MR antagonists like spironolactone, canrenoate and eplerenone are used for decades in patients with hypertension or, more recently, with heart failure. Therefore pharmacokinetic and toxicol...

Frederic Jaisser, MD, PhD has a permanent position as Director of Research at the National Institute of Health and Medical Research (INSERM) from 1996. Dr Jaisser received his medical training and degrees from the Reims Medical School and qualified as Nephrologist in 1990. In 2003, he joined the Collège de France in Paris as part of an independent INSERM team and is currently the director of a team of the INSERM ...