Endocrine Abstracts

Thyroid hormone (TH) signalling regulates tissues function in virtually all organs and exerts a striking impact on brain development and function. The major secretory product of the human thyroid gland is thyroxine (T4), a stable pro-hormone. In order to bind the TH receptor TR, T4 needs to get converted to T3 by deiodination. The hypothalamo-pituitary-thyroid (HPT) axis controls circulating TH levels, that show remarkable stability. However, tissue TH action undergoes vigorou...

Thyroid hormones play an important role in all stages of life, including old age. Several differences have been observed in thyroid function parameters with age, including an increase in circulating thyroid stimulating hormone (TSH) levels gradually increase with age. In order to identify determinants of human longevity, the Leiden Longevity Study (LLS) included 421 families with at least two long-lived Caucasian siblings fulfilling the age criteria (men ≥89 years and wo...

Abstract unavailable....