Endocrine Abstracts

Quantitation of insulin in human plasma was first achieved by Berson and Yallow in 1960, as reported in their seminal paper describing radio-immunoassay (J Clin Invest. 1960(7)39:1157). Despite the wider availability of insulin assays, improvements in immunoassay design and the advent of mass-spectrometric methods to quantitate insulin, insulin assays are used far less than other hormone assays in endocrinological investigations. This is largely due to the dynamic nature of in...

Insulin-like growth factor-1 (IGF-I) is a 70-amino acid peptide hormone which is the principal mediator of the effects of growth hormone (GH). Pituitary GH is secreted in a pulsatile manner and is subjected to various environmental and physiological stimuli. In contrast, IGF-I is synthesised in a more stable manner and has a longer half-life therefore it is a more reliable biomarker of GH status. Hence IGF-I measurements are essential for the diagnosis and treatment of GH defi...

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