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Endocrine Abstracts

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Society for Endocrinology BES 2019

Brighton, United Kingdom
11 Nov 2019 - 13 Nov 2019

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Come and exchange knowledge, share experiences and strengthen collaborations across our global community of endocrinologists!

EARLY CAREERS AND PLENARY ORALS

Early Career Prize Lecture Basic Science

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Early Career Prize Lecture Translational

ea0065ec1.1 | Early Career Prize Lecture Basic Science | SFEBES2019

Unravelling of new type 2 diabetes genes with 3D chromatin topology analysis and CRISPR-Cas9 perturbations

Cebola Ines , Miguel-Escalada Irene , Bonas-Guarch Silvia , Ponsa-Cobas Joan , Atla Goutham , Javierre Biola , Ravassard Philippe , Fraser Peter , Ferrer Jorge

Genome-wide association studies have identified nearly 250 loci carrying genetic variants associated with type 2 diabetes (T2D) susceptibility, which are often located within pancreatic islet transcriptional enhancers. Due to the complex nature of transcriptional enhancers, assigning risk variants to true disease susceptibility effector genes has remained a challenge. In this study, we applied promoter capture Hi-C to create a genome-wide map of promoter-enhancer interactions ...
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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