Miscellaneous

Background: Diagnostic thyroid scans using technetium-99m pertechnetate are widely used to differentiate the causes of hyperthyroidism. Only 1-5% of the administered isotope is taken up by the thyroid after 20 minutes resulting in high background radioactivity.Objectives: To determine the effective radiation dose and calculated organ doses after a standard administration of Technetium-99m pertechnetate</ce:under...

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ea0084ps1-05-38 | Miscellaneous | ETA2022

TSH is superior to T4 for the assessment of thyroid function

Andersen Stig , Linding Andersen Stine , Bruun Henrik , Riis Johannes , Noahsen Paneeraq , Westergaard Louise , Karmisholt Jesper

Background: Morbidity and mortality are associated with thyroid hormone levels in populations. This has invited a debate on what is the better parameter for assessment of thyroid function: the controlling hormone thyrotropin (TSH) or peripheral thyroid hormone measurements (thyroxine (T4) and triiodothyronine (T3)).Aim: To assess the ability of TSH and total T4 (TT4) to discriminate between subtle differences in thyroid function.Me...

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ea0084ps1-05-39 | Miscellaneous | ETA2022

The effect of obesity-related allostatic changes on cardio-metabolic risk in euthyroid children

Wasniewska Malgorzata , Tropeano Angelo , Corica Domenico , Curatola Selenia , Li Pomi Alessandra , Pepe Giorgia , Aversa Tommaso

Purpose: The hormonal thyroid changes related to obesity, even when in the euthyroid state, may contribute to the unfavorable cardio-metabolic profile of obese patients. In this retrospective study we aim to investigate the biochemical thyroid changes and the association between serum TSH, FT4, FT3 and cardio-metabolic risk factors in euthyroid obese youths.Methods: Four hundred ninety-one Caucasian euthyroid obese children and adolescents aged 9.93&pm;2...

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ea0084ps1-05-40 | Miscellaneous | ETA2022

Thyroid hormone variability and cardiovascular morbidity in hyperthyroid patients treated with long-term antithyroid drug therapy

Pajamaki Nelli , Laihia Iina , Huhtala Heini , Jaatinen Pia , Metso Saara

Objectives: The variability of thyroid hormone levels during long-term antithyroid drug (ATD) therapy and its possible association with adverse health outcomes has not been previously studied. The aim of this study was to evaluate the association of thyroid function test (TFT) variability and cardiovascular disease (CVD) morbidity during long-term ATD therapy. Furthermore, clinical factors related to high TFT variability during the ATD therapy were identified.<p class="abs...

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ea0084ps1-05-41 | Miscellaneous | ETA2022

I-131 treatment of patients with autonomously functioning thyroid nodules and normal TSH blood level

Lacic Miodrag

Objectives: The purpose of this study was to evaluate the results of radionuclide therapy with iodine-131 (I-131) in patients (pts) with autonomously functioning thyroid nodules (AFTNs) and a normal thyroid stimulating hormone (TSH) blood level.Methods: In this study 110 cytological benign AFTNs in 98 pts (83 female and 15 male) with normal TSH level have been treated with a fixed I-131 doses (370 MBq). Clinical exam, ultrasonography with color Doppler (...

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ea0084ps1-05-42 | Miscellaneous | ETA2022

Not all automated FT4 immunoassays measure accurately in samples of pregnant women and hemodialysis patients

Jansen Heleen , van Herwaarden Antonius , Vervloet Marc , Painter Rebecca , Huijgen Henk , Hillebrand Jacquelien , Boelen Anita , Heijboer Annemieke

Objectives: Free thyroxine (fT4) measurements are performed to detect thyroid disorders and monitor treatment. FT4 is measured using automated immunoassays (IAs) which face established analytical challenges due to low serum concentrations in the picomolar range and the precarious equilibrium between free and bound T4 (to thyroid-binding globulin (TBG) and (pre-)albumin). Furthermore, IAs are known to be affected by the composition of the serum sample (matrix-effects), which ca...

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ea0084ps1-05-43 | Miscellaneous | ETA2022

Treatment of hyperthyroidism reduces the systemic oxidative stress load, as measured by biomarkers of rna and dna damage

Bogelund Larsen Camilla , Ryom Riis Kamilla , Hillert Winter Kristian , List Larsen Emil , Ellervik Christina , Hegedus Laszlo , Brix Thomas , Enghusen Poulsen3 Henrik , Joop Bonnema Steen

Background: Increased oxidative stress has been linked to both hypo- and hyperthyroidism. Whole-body oxidative stress can be estimated by the oxidized guanine nucleosides, 8-oxo-7,8-dihydroguanosine (8-oxoGuo) and 8-oxo-7,8-dihydro-2-deoxyguanosine (8-oxodG), derived from RNA and DNA, respectively. These biomarkers have been associated with increased morbidity and mortality in several diseases but are not well explored in humans with thyroid disorders.<p class="abste...

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ea0084ps1-05-44 | Miscellaneous | ETA2022

The effect of testosterone supplementation on the hpt axis in euthyroid hypogonadal adult men: a prospective observational study

David Karel , Antonio Leen , Claessens Frank , Vanderschueren Dirk , Decallonne Brigitte

Background and Objective: It is known that androgens decrease and estrogens increase TBG. In female to male transsexuals under testosterone replacement, decrease of TBG has been shown, but also an increased T3/T4 ratio despite stable free T4 and TSH, suggesting increased conversion to T3 by testosterone. We wanted to study the HPT axis in hypogonadal cis-males before and after testosterone replacement.Method: Prospective observational study in adult male...

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ea0084ps1-05-45 | Miscellaneous | ETA2022

Abstract Withdrawn...

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ea0084ps1-05-46 | Miscellaneous | ETA2022

Body composition determinants of thyroid function and volume in euthyroid patient with obesity

Sirbu Anca , Busuioc Denisa , Martin Sorina , Barbu Carmen , Fica Simona

The aim of our study was to investigate de relationship between anthropometric and body composition parameters and thyroid function (measured with TSH and free T4), as well as thyroid volume, in patients with obesity.Methods: This is a cross-sectional study including patients with obesity consecutively referred to our tertiary endocrine center for diverse pathologies. TSH and free T4 was measured in all patients and thyroid ultrasound was performed by an...

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Endocrine Abstracts

44th Annual Meeting of the European Thyroid Association (ETA) 2022

Poster Presentations

The sollid study (simplification of low level internal dosimetry): preliminary findings

TSH is superior to T4 for the assessment of thyroid function

The effect of obesity-related allostatic changes on cardio-metabolic risk in euthyroid children

Thyroid hormone variability and cardiovascular morbidity in hyperthyroid patients treated with long-term antithyroid drug therapy

I-131 treatment of patients with autonomously functioning thyroid nodules and normal TSH blood level

Not all automated FT4 immunoassays measure accurately in samples of pregnant women and hemodialysis patients

Treatment of hyperthyroidism reduces the systemic oxidative stress load, as measured by biomarkers of rna and dna damage

The effect of testosterone supplementation on the hpt axis in euthyroid hypogonadal adult men: a prospective observational study

Body composition determinants of thyroid function and volume in euthyroid patient with obesity

BiosciAbstracts