Endocrine Abstracts

Fertility is critically dependent upon episodic gonadotropin hormone secretion. Recent studies using genetic mouse models have identified that a population of kisspeptin neurons located in the arcuate nucleus (ARN) represent the gonadotropin-releasing hormone (GnRH) pulse generator in both males and females. These cells exhibit abrupt periods of synchronised activity for 1-2 min that, in turn, activate GnRH neuron processes to release GnRH over a similar time scale to drive pu...