Reproductive and Developmental Endocrinology

ea0099p141 | Reproductive and Developmental Endocrinology | ECE2024

Copeptin and oxytocin in MDMA-induced hyponatremia:incidence and severity, mechanisms of action, and the effect of fluid restriction

Atila Cihan , Straumann Isabelle , Vizeli Patrick , Beck Julia , Monnerat Sophie , Holze Friederike , Liechti Matthias , Christ-Crain Mirjam

Importance: 3,4-Methylenedioxymethamphetamine (MDMA, ecstasy) is a trending recreational drug but also has potential to enter clinical practice. Acute hyponatremia is a serious complication arising from ingesting even a single dose of MDMA. The assumed aetiology is a vasopressin release inducing the syndrome of inappropriate anti-diuresis combined with increased thirst causing polydipsia and thus water intoxication.Methods: Pooled analysis of...

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ea0099p142 | Reproductive and Developmental Endocrinology | ECE2024

Decoding desire: a neurofunctional exploration of distressing low sexual desire reveals sexually dimorphic brain responses

Tsoutsouki Jovanna , Ertl Natalie , G Mills Edouard , B Wall Matt , Thurston Layla , Yang Lisa , Hunjan Tia , Phylactou Maria , Bassett Paul , Patel Bijal , Howard Jonathan , Abbara Ali , Goldmeier David , Comninos Alexander , Dhillo Waljit

Background: Distressing low sexual desire, termed Hypoactive Sexual Desire Disorder (HSDD), affects 10% of women and 8% of men. The established top-down neurofunctional model of HSDD in women suggests that in response to erotic cues, excessive activation of higher-level cognitive brain regions (involved in introspection/self-monitoring) suppresses lower-level sexual brain centres, thereby impeding normal sexual function. By contrast, the neurodysfunction in men wit...

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ea0099p143 | Reproductive and Developmental Endocrinology | ECE2024

Receptor-mediated internalisation of the long-acting growth hormone analogue somapacitan in comparison with recombinant human growth hormone and pegvisomant

Brandt Matthaus , Kassianidou Elena , Behrens Carsten , Thygesen Peter

Growth hormone receptor (GHR) internalisation plays a crucial role in GHR activation and signalling by controlling the availability of the receptor for binding growth hormone (GH), regulating the intensity and duration of the GH signal, initiating unique signalling pathways, and maintaining homeostasis in the GH signalling pathway. GHR internalisation occurs mainly through clathrin-mediated endocytosis. Upon GH binding, the GHR undergoes ubiquitination, which is a signal for i...

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ea0099p144 | Reproductive and Developmental Endocrinology | ECE2024

Adopted transgender subjects are over represented and have a different psychosocial profile than their non-adopted counterparts: a case-control study

Yaish Iris , Greenman Yona , Tordjman Karen

Background and Aim: We previously demonstrated (1) that in our transgender clinic, adoptees are significantly overrepresented compared to the general population, suggesting early life traumas may play a role in the etiology of transgenderism. We had also shown a large preponderance (close to 80%) of female sex-assigned-at-birth (SAB), and a trend for presenting for treatment at an older age than non-adopted subjects. In the current study we aimed to further characterize this s...

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ea0099p145 | Reproductive and Developmental Endocrinology | ECE2024

European survey of diagnosis and management of the polycystic ovary syndrome: full report on the ESE PCOS special interest group’s 2023 questionnaire

Livadas Sarantis , Yildiz Bulent , Mastorakos George , Gambineri Alessandra , Pignatelli Duarte , Giorgino Francesco , Andersen Marianne , Obermayer-Pietsch Barbara , P. Macut Djuro

Background: Although polycystic ovary syndrome (PCOS) constitutes a common endocrinopathy, there are several issues which confuse clinicians during everyday practice.Objective: To define the current status of knowledge of the full spectrum of PCOS among European endocrinologists.Methods: A detailed questionnaire comprising 41 items covering various aspects of diagnosis and management of women with PCOS was shared via web among memb...

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ea0099p146 | Reproductive and Developmental Endocrinology | ECE2024

The role of menstrual cycle changes in the evaluation of women’s reproductive, sexual and mental health – lessons learned from the covid-19 pandemic

Saravinovska Kristina , Marina Ljiljana , Delic Neda , Stefan Sojat Antoan , Radonjic Nevena , Mihajlovic Sladjana , Lackovic Milan , Gunjic Ilija , Petkovic Tijana , Antic Natalija , Jankov Emilija , Arizanovic Zorana , Ivovic Miomira , Vujovic Svetlana

Introduction: It has been shown that women with a previous Sars-CoV-2 infection have long-lasting menstrual cycle (MC) changes.Aim: To investigate the MC changes and their relationship with womens reproductive, sexual and mental health disturbances during the COVID-19 pandemic.Methods: Anonymous survey about reproductive, sexual and mental health was shared with women of reproductive age between May 2022 and November 2023. Al...

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ea0099p147 | Reproductive and Developmental Endocrinology | ECE2024

Revised adolescent PCOS criteria: implications for women’s metabolic well-being

Nowak-Ciołek Maria , Stachowiak Julia , Krok Katarzyna , Sokal Julia , Malczyk Żaneta , Zachurzok Agnieszka

Introduction: Polycystic ovary syndrome (PCOS) is one of the most common endocrinopathies in women. In recent years revised diagnostic criteria for PCOS in adolescent females were disseminated. These new criteria notably encompass the specification of irregular menstrual cycles and hyperandrogenism, with the exclusion of polycystic ovarian morphology. In our study, we aimed to verify whether the clinical presentation of adolescent patients meeting the new criteria is associate...

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ea0099p148 | Reproductive and Developmental Endocrinology | ECE2024

Use of combined oral contraceptive pills in women with and without PCOS: A longitudinal population-based cohort study

Forslund Maria , Melin Johanna , Loxton Deborah , Teede Helena , Joham Anju , Thien Tay Chau

Objective: Combined oral contraceptive pills (COCP), primarily used for contraception; are also indicated in other conditions including polycystic ovary syndrome (PCOS). Evidence on the prevalence and patterns of COCP use in PCOS compared to those without the condition are unknown, and studies in unselected populations, especially longitudinally, are very limited. The aim of this study was to examine prevalence and patterns of COCP use in women with PCOS, compared to the backg...

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ea0099p149 | Reproductive and Developmental Endocrinology | ECE2024

The impact of testosterone on TLR expression in transgender men

Cihan Huseyin , Gungor Ozge , Unal Kocabaş Gokcen , Pehlivan Koroğlu Esma , Gulpınar Kubra , Parıltay Erhan , Omur Ardeniz Fatma , Winzeler Bettina , Şarer yurekli Banu

Background: Sex based differences in the immune system are well-documented in the literature. The influence of sex on the immune system is primarily attributed via chromosomal and sex hormone mediation. Cis men generally exhibit a weaker immune response compared to cis women. This contrast extends to various immune-mediated diseases, where cis men show a higher incidence of cancer but fewer autoimmune diseases than cis women. Testosterone is part of gender affirming masculiniz...

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ea0099p150 | Reproductive and Developmental Endocrinology | ECE2024

Prevalence of polycystic ovary syndrome in women with prediabetes

Sulu Cem , Ozkaya Hande , Damci Taner , Kelestimur Fahrettin , Gonen Mustafa

Objective: To determine the frequency of polycystic ovary syndrome (PCOS) in women with prediabetes compared to control women.Methods: Digital screening and tele-interviews remotely excluded 3218 out of 3465 consecutive women applied for routine check-up. In-person assessments were performed on 247 women, excluding 49. Final analyses included 198 premenopausal women without endocrine disorders (other than prediabetes and PCOS) or conditions affecting gon...

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ea0099p151 | Reproductive and Developmental Endocrinology | ECE2024

Thyroid autoimmunity can negatively influence placental angiogenic factors and hormone secretion

Tańska Kamila , Glinicki Piotr , Rebizant Beata , Zgliczyński Wojciech , Gietka-Czernel Małgorzata

Introduction: Thyroid autoimmunity (TAI) commonly defined as the presence of thyroperoxidase antibodies (TPOAbs) and/or thyroglobulin antibodies (TgAbs) affects up to 15 percent of women of reproductive age and is a well-known risk factor of pregnancy loss. One of the possible explanations of obstetrical complications might be the disturbed process of placentation caused by thyroid antibodies. To test this hypothesis, we evaluated placental hormonal function and placental angi...

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ea0099p152 | Reproductive and Developmental Endocrinology | ECE2024

Comparative analysis of pain characteristics in women with and without endometriosis

Oren Lana , Thoppil Lijamol , Mkheidze George , Meerzon Yaron , Kaldani Salome , Tandashvili Lela

Objective: Endometriosis is a condition marked by presence of endometrial tissue outside the uterus, causing inflammation, adhesions, and pelvic structural changes.1 Despite its impact on womens quality of life, endometriosis symptoms are viewed as nonspecific, overlapping with other gynecological diseases and are normalized 2, all contributing to a long delay in diagnosis. This cross-sectional study aimed to address these issues by analysing distri...

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ea0099p153 | Reproductive and Developmental Endocrinology | ECE2024

Sexual function, quality of life and gender-related differences in patients with well-differentiated neuroendocrine tumors

Mazzilli Rossella , Zamponi Virginia , Modica Roberta , Scandurra Cristiano , Mancini Camilla , Sesti Franz , Feola Tiziana , Giannetta Elisa , Mauro Maldonato Nelson , Colao Annamaria , Faggiano Antongiulio

Introduction: Neuroendocrine neoplasms (NEN) represent a group of rare neoplasms characterized by wide heterogeneity in terms of biological characteristics and clinical behavior. Despite their increasing relevance in the oncology field, health-related quality of life (HRQoL) and sexual function remain poorly investigated.Aim: To investigate sexual function in patients affected by NEN; to evaluate the impact of clinical severity (presence or absence of me...

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ea0099p154 | Reproductive and Developmental Endocrinology | ECE2024

Aromatase inhibitors and abrupt increase obesity rates among in males during puberty

Jamburia Rezo , Bakhtadze Tekle , Janjgava Shota , Davitashvili Ana , Goletiani Natia , Zhgenti Medea , Giorgadze Elene

Even in the presence of normally circulating androgens, the imbalance between estrogen and androgen in males between the prepubertal and pubertal periods may have an impact on male reproductive function. While there are many variables that affect how each person reaches puberty at different times, boys who are becoming more obese have higher aromatase activity. This enzyme turns testosterone into estradiol permanently, which lowers testosterone levels and raises estrogen level...

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ea0099p207 | Reproductive and Developmental Endocrinology | ECE2024

Diagnosis experiences in an international sample of lean women with PCOS

Masters Melissa , Dropping Kenlee , Parry-Jones Amie , Sinley Rachel

Background: Polycystic Ovary Syndrome (PCOS), an endocrine disorder affecting 9-18% of reproductive-aged women, impacts all body types including those with a normal body mass index (BMI) often termed lean or atypical PCOS. This study aimed to investigate the diagnosis experience in an international sample of lean women with PCOS.Methods: Participants were recruited from social media sites aimed at women with PCOS. Eligibility criteria included being &#88...

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ea0099p211 | Reproductive and Developmental Endocrinology | ECE2024

The impact of motivational interviews and hospitalization in themanagement of obesity associated infertility

Jankovic Dijana , Saravinovska Kristina , Delic Neda , Stefan Sojat Antoan , Gunjic Ilija , Ivovic Miomira , Petkovic Tijana , Antic Natalija , Mitrovic Dragana , Mutavdzic Suzana , Arizanovic Zorana , Vujovic Svetlana , Marina Ljiljana

Introduction: The interplay between obesity and hormones has a profound impact on womens reproductive health, reducing the likelihood of successful conception.Methods: We performed a 6-month longitudinal study. The inclusion criteria were: women aged 20-40 with infertility, regular anovulatory menstrual cycles, BMI 35-40 kg/m², unrelated to other diseases. 30 eligible women were categorized into three groups: Group 1 (G1) received motivational...

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ea0099p352 | Reproductive and Developmental Endocrinology | ECE2024

Early response with fezolinetant treatment of moderate-to-severe vasomotor symptoms associated with menopause in women considered unsuitable for hormone therapy: phase 3b daylight study

Linden Hirschberg Angelica , Bouchard Celine , Cano Antonio , Schaudig Katrin , Martins Karla , Miyazaki Kentaro , Wu Xi , Wang Xuegong

Introduction: There is a need for well tolerated and effective nonhormonal therapies for vasomotor symptoms (VMS) associated with menopause. Fezolinetant is a nonhormonal, selective neurokinin 3 receptor antagonist that is approved for the treatment of moderate-to-severe VMS associated with menopause.Objective: To assess how early a response to fezolinetant in frequency and severity of moderate-to-severe VMS was observed in the 24-week placebo-controlled...

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ea0099p353 | Reproductive and Developmental Endocrinology | ECE2024

Renal 11β-hydroxysteroid dehydrogenase type 2 is of central importance for 11-oxygenated androgen biosynthesis and is disrupted in chronic kidney disease

Tomkins Maria , McDonnell Tara , Cussen Leanne , S Sagmeister Michael , Oestlund Imken , Shaheen Fozia , Harper Lorraine , S Hardy Rowan , E Taylor Angela , C Gilligan Lorna , Arlt Wiebke , McIlroy Marie , de Freitas Declan , Conlon Peter , Magee Colm , Denton Mark , O'Seaghdha Conall , Snoep Jacky , Heinz-Storbeck Karl , Sherlock Mark , W O'Reilly Michael

11-oxygenated androgens are a group of adrenal-derived C19 steroids that require activation in peripheral tissues. 11β-hydroxysteroid dehydrogenase type 2 (HSD11B2) has been shown in vitro to be essential for 11-oxygenated androgen activation, converting 11β-hydroxyandrostenedione (11OHA4) to 11-ketoandrostenedione (11KA4), the direct precursor of the potent androgen 11-ketotestosterone (11KT). As the kidney is the major site of HSD11B2 expression, we hypoth...

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ea0099p354 | Reproductive and Developmental Endocrinology | ECE2024

Abstract withdrawn...

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ea0099p355 | Reproductive and Developmental Endocrinology | ECE2024

Gonadal and sexual function in men living with HIV: a real-life single centre experience

Bonaventura Ilaria , Hasenmajer Valeria , Sada Valentina , Cerroni Lorenzo , D'Addario Nicolo , D'Ettorre Gabriella , Mastroianni Claudio , Pozza Carlotta , Gianfrilli Daniele

Background: Hypogonadism and sexual dysfunction, particularly erectile dysfunction (ED), are common in men living with HIV (MLWH), but the link between testosterone levels and sexual function remains unclear in this population. The aim of this study was to estimate the prevalence of hypogonadism and sexual dysfunction and to explore the relationship between HIV-related variables and gonadal and sexual function in MLWH.Materials and Methods: Serum total t...

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ea0099p356 | Reproductive and Developmental Endocrinology | ECE2024

Clinical, biological and socio-professional characteristics of patients harboring the 46,XX/47,XXY mosaic sex chromosome aneuploidy: the MOSAI-XX multicenter study

Zaegel Nadia , Plotton Ingrid , Bouvattier Claire Morel , Chasseloup Fanny , Maiza Jean-Christophe , Vanakker Olivier , Kamenicky Peter , Salenave Sylvie , Lucie Tosca , Veyt Nathalie , Young Jacques , Maione Luigi

Background: Sex chromosome mosaic aneuploidy 46,XX/47,XXy (mKS-XX) is a very rare syndrome, with only twenty-one cases previously reported. No patients series with mKS-XX and no comparative studies between mKS-XX and the common homogeneous Klinefelter syndrome (KS) have so far been described.Aims: To describe the clinical, biological and socio-professional characteristics of the first series of previously unpublished patients with mKS-XX. To find p...

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ea0099p357 | Reproductive and Developmental Endocrinology | ECE2024

Regulation of PGR gene expression in immortalized human endometrial stromal cells

Monserrat Retis Resendiz Alejandra , Paloma Dominguez Mora Martha , Cid-Cruz yesenia , Leon-Juarez Moises , Romero Reyes Jessica , Garcia-Gomez Elizabeth , Camacho-Arroyo Ignacio , Ricardo VAZquez Martinez Edgar

Background: Decidualization, a crucial process for successful pregnancy establishment and maintenance, involves endometrial stromal cell differentiation. This process is orchestrated by estradiol (E2), progesterone, and other stimuli that increase intracellular cyclic adenosine monophosphate (cAMP) levels. The progesterone receptor (PR) plays a pivotal role in regulating decidualization, and alterations in its expression are linked to endometrial pathologies. However, the mech...

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ea0099p358 | Reproductive and Developmental Endocrinology | ECE2024

Congenital hypogonadotropic hypogonadism by PNPLA6 mutations: identification of a wide phenotypic spectrum and functional correlations with the NTE in vitro activity

Maione Luigi , Bouligand Jerome , Rousseau Antoine , Prevost Salome , Naule Lydie , Salenave Sylvie , Chanson Philippe , Kaiser Ursula , young Jacques

Background: PNPLA6 mutations are associated with complex autosomal recessive disorders including congenital hypogonadotropic hypogonadism (CHH): Gordon-Holmes syndrome, Boucher-Neuhauser syndrome and hereditary spastic paraplegia, which include ophthalmologic and neurologic disorders in addition to CHH. PNPLA6 gene encodes the neuropathy target esterase (NTE), an endoplasmic reticulum-associated enzyme intervening in the metabolism of membrane phospholipids.<...

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ea0099p359 | Reproductive and Developmental Endocrinology | ECE2024

Expression of the serotonin signaling pathway in a testicular adrenal rest tumor in a patient with 21-hydroxylase deficiency

Menager Lola , Rives-Feraille Aurelie , Moutard Laura , Rives Nathalie , Lefebvre Herve , Louiset Estelle

Testicular adrenal rest tumors (TART) are frequently detected in male patients with 21-hydroxylase (21-OH) deficiency. Increase in plasma ACTH levels, due to cortisol deficit, is responsible for TART growth. Indeed, glucocorticoid substitution reduces both plasma ACTH and TART development in the majority of patients. Nevertheless, some patients with TART are resistant to the glucocorticoid treatment, suggesting the existence of other factors stimulating TART growth. The aim of...

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ea0099p360 | Reproductive and Developmental Endocrinology | ECE2024

Different adipose tissue depots: metabolic implications in polycystic ovary syndrome

Basnet Jelina , Rezq Samar , M Huffman Alexandra , L yanes Cardozo Licy , G Romero Damian

Background: Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in reproductive-age women. PCOS women often have hyperandrogenemia that is associated with adiposity and a worse metabolic profile. However, the depots-specific effect of different white adipose tissues (WAT) in mediating the systemic metabolic dysfunction is not fully understood in PCOS. Therefore, using a well-established mouse model of PCOS, we aim to test the hypothesis that excess androgen ...

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ea0099p361 | Reproductive and Developmental Endocrinology | ECE2024

Prenatal testosterone exposure and offspring body composition at 7 years-of-age. odense child cohort

Palm Camilla , Glintborg Dorte , Grontved Anders , Jensen Dorte , Hansen Freja , Jorgensen Jan , Christesen Henrik , Jensen Tina , Andersen Marianne

Background: Maternal free testosterone (FT) increases during 3rd trimester pregnancy and FT levels are higher in women with polycystic ovary syndrome (PCOS) compared to controls. Fetal exposure to maternal FT during 3rd trimester was associated with lower weight, length and shorter abdominal circumference at birth, in boys. Furthermore, lower birth weight has been related to higher abdominal fat mass in young children.Aim: To examine associations between...

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ea0099p362 | Reproductive and Developmental Endocrinology | ECE2024

Mental health and illness uncertainty of individuals with polycystic ovarian syndrome: how is the quality of life affected?

Celik Selda , Murat Merve , Anataca Gulden , Peynirci Hande

Introduction: Polycystic ovary syndrome (PCOS) stands out as one of the prevalent endocrine disorders affecting women in their reproductive years, impacting 8-13% of females as per World Health Organization (WHO) statistics. This condition has significant repercussions on a womans sense of self, mental well-being, and overall life quality. While individuals with PCOS often grapple with anxiety and sadness throughout the diagnosis and treatment phases, external factors ca...

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ea0099p363 | Reproductive and Developmental Endocrinology | ECE2024

A multinational study to explore the management of dermatological manifestations associated with polycystic ovary syndrome (PCOS) across europe

Lafara Kyranna , Mintziori Gesthimani , Goulis Dimitrios , Arshad Amynta , Khan Sahrish , Chu Agatha , James Angharad , Abdullayeva Elmira , Dekode Team

Objective: To investigate the management of dermatological manifestations associated with PCOS and its management across Europe.Methods: This multinational retrospective study was conducted from June 2023 to January 2024. All women over 18 years of age attending a first consultation for PCOS from 1st January 2020 to 30th December 2023 in the UK (n=359), Turkey (n=239), Greece (n=92) and Georgia (n=10) were included. Th...

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ea0099p364 | Reproductive and Developmental Endocrinology | ECE2024

The risk of obesity and metabolic complications in hyperandrogenic physically inactive young women with PCOS

Kuliczkowska-Płaksej Justyna , Jawiarczyk-Przybylowska Aleksandra , Gojny Lukasz , Zdrojowy-Wełna Aleksandra , Lwow Felicja , Bolanowski Marek

Background: Polycystic ovary syndrome (PCOS) is a condition affecting up to 20% of reproductive-aged women. PCOS is associated with obesity and serious metabolic complications. There is a lack of research evaluating differences in metabolic complications between hyperandrogenic physically active and inactive individuals.Objective: We used a cross-sectional study to compare the risk of obesity, metabolic syndrome, visceral adipose index, and insulin resis...

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ea0099p365 | Reproductive and Developmental Endocrinology | ECE2024

Early changes in muscle strength and body composition under gender-affirming hormonal therapy in transgender people assigned female at birth

Hanife Oguz Seda , Erturk Banu , Guneri Sinem , Cetin Alp , Yildiz Bulent

Background: The effects of gender-affirming hormonal therapy (GAHT) on body composition in transgender people assigned female at birth (AFAB) have been an area of interest. However, the impact of GAHT on muscle strength remains inadequately studied. We aimed to evaluate early alterations in muscle strength following GAHT in transgender people AFAB by isokinetic dynamometry, the gold standard for assessment of strength.Subjects and Methods: A total of 20 ...

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ea0099p366 | Reproductive and Developmental Endocrinology | ECE2024

“Brief intelligence test” questionnaire in klinefelter syndrome: may words improve diagnosis?

Vimercati Davide , Marinelli Lorenzo , Cagnina Serena , Daffara Tommaso , Bichiri Andrea , Di Bisceglie Cataldo , Motta Giovanna , Lanfranco Fabio , Zavattaro Marco

Background: The clinical burden of Klinefelter Syndrome (KS) is not limited to the impairment of gonadal function and an increased prevalence of cardio-metabolic, endocrinological and oncological diseases, but also involve several cognitional, behavioural and psychological issues. Because of the wide heterogeneity in clinical phenotype, the diagnosis of KS is still challenging, resulting in a significant number of patients to remain undiagnosed or to have a late diagnosis. Ver...

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ea0099p550 | Reproductive and Developmental Endocrinology | ECE2024

Comprehensive WES reanalysis of rare endocrine patients for the identification of novel disease-causing genes

Yousaf Muhammad , Zanobio Mariateresa , Allosso Francesca , Nigro Vincenzo , Pasquali Daniela

Rare diseases affect more than 300 million people worldwide, often lead to chronic illness, disability, and premature death. The recent advancements in genetics through Next Generation Sequencing (NGS) have revolutionized research and diagnostics. NGS technologies allowed the identification of novel candidate disease-causing genes, significantly also in-depth modification of our understanding of genetic architecture of various rare endocrine diseases. However, despite these re...

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ea0099p551 | Reproductive and Developmental Endocrinology | ECE2024

Endocrine responses to kisspeptin in an unusual case of kallmann syndrome with unilateral anosmia

Tsoutsouki Jovanna , N Comninos Alexander , Phylactou Maria , Patel Bijal , Mills Edouard , Young Megan , Yeung Arthur , Koysombat Kanyada , Modi Manish , Papadopoulou Deborah , Howard Sasha , S Dhillo Waljit , Abbara Ali

Introduction: Kallmann syndrome (KS) is a rare condition characterised by congenital hypogonadotropic hypogonadism (CHH), usually due to defective migration of olfactory axons and GnRH-neurons. KS is typically associated with absent (anosmia) or reduced (microsmia) sense of smell. Unilaterally hypoplastic or absent olfactory bulbs on MRI are reported, although disturbance in smell is usually bilateral. Kisspeptin is a potent stimulator of hypothalamic GnRH-neurons, and endocri...

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ea0099p552 | Reproductive and Developmental Endocrinology | ECE2024

Hypoechoic testicular lesions in klinefelter syndrome show volumetric reduction in response to testosterone therapy

Ferrari Davide , Sesti Franz , Tenuta Marta , Carlomagno Francesco , Gianfrilli Daniele , Pozza Carlotta , Isidori Andrea

Introduction: Patients with Klinefelter Syndrome (KS) often display small, multiple, non-palpable, and typically benign testicular micro-nodules at ultrasonographic examination, representing Leydig cell hyperplasia or Leydig tumors. Increased LH levels raising from testicular damage might play a pivotal role by acting as growth factor for Leydig cells. To date, evidence on the efficacy of testosterone replacement therapy (TRT) on decreasing the micro-nodules volume are lacking...

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ea0099p553 | Reproductive and Developmental Endocrinology | ECE2024

Patient and public involvement in simulation via instant messaging – birmingham advance (SIMBA) training improves clinicians’ confidence in managing reproductive endocrinology cases

Ravi Sangamithra , Ogiliev Tamzin , Elhariry Maiar , Sakthivel Pavithra , Radcliffe Abby , Sagu Rahul , Balakrishnan Harshin , Zhou Dengyi , Kempegowda Punith , and Comics team Simba

Introduction: Simulation via Instant Messaging Birmingham Advance (SIMBA) is a virtual simulation-based medical training model that improves clinicians confidence. However, it has lacked input from patients living with these conditions. Engaging patients and members of the public in the formulation and discussion of cases could guide clinicians to tailor management to meet the concerns and expectations of patients better.Method: A two-day co...

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ea0099p554 | Reproductive and Developmental Endocrinology | ECE2024

Revitalizing kidney health in polycystic ovary syndrome: a novel approach— targeting STAT3 signaling for restored mitochondrial function and reduced kidney injury

Rezq Samar , Basnet Jelina , M Huffman Alexandra , Flaherty Joseph , H Hoang Ngoc , Edwards Kristin , L Yanes Cardozo Licy , G Romero Damian

Background: Polycystic ovary syndrome (PCOS) is characterized by hyperandrogenism and polycystic ovaries. Renal injury is prevalent in PCOS, yet the molecular mechanisms are poorly understood. The JAK/STAT3 signaling pathway, activated by the inflammatory cytokine interleukin-6 (IL-6), negatively impacts renal mitochondrial function to induce oxidative stress and renal injury. Despite its chronic activation by excess androgen in extra-renal tissues in PCOS, its role in PCOS as...

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ea0099p555 | Reproductive and Developmental Endocrinology | ECE2024

Klinefelter syndrome is associated with early-onset metabolic defects that are not reversed by testosterone therapy

Chouchane Karim , Hofbauer Susanna , Giordani Ilaria , nathalie vionnet , Barigou Mohammed , Pitteloud Nelly , Hauschild Michael , Papadakis Georgios

Background: Klinefelter syndrome (KFS) is the most common chromosomal aberration in men, characterized by an extra-X chromosome (47, XXY). Besides the well-known reproductive defects, KFS is characterized by a 4-fold increase in metabolic syndrome, cardiovascular morbidity and mortality. The exact cause of this constellation remains unclear.Methods: Data from non-mosaic KFS adults and adolescents, evaluated in the endocrine unit of Lausanne University Ho...

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ea0099p556 | Reproductive and Developmental Endocrinology | ECE2024

4 Cases of postmenopausal hyperandrogenism in glasgow

Leong Ashley , Azharuddin Mohammed , Jones Chris , Abdelrahman Hiba

Background: New onset postmenopausal hyperandrogenism (PMH) is rare and is a diagnostic and therapeutic challenge.Clinical Case: AB, a 69-year woman, had 14-years of hirsutism and 1-year of male-pattern balding. Androgen profile was high: testosterone (T) 4.9nmol/L, androstenedione (A) 3.7nmol/L, 17OHP 2.3nmol/L. DHEAS and pre- and post-1 mg ONDST cortisol was normal. Adrenals and ovaries on CT were unremarkable, hence benign ovarian source assumed. She ...

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ea0099p557 | Reproductive and Developmental Endocrinology | ECE2024

MiRNAs specific for PCOS phenotypes

Trummer Olivia , Hoeller Jonas , Reintar Sharmaine , Tandl Veronika , Foszl Ines , Borzan Valentin , Theiler-Schwetz Verena , Trummer Christian , Lerchbaum Elisabeth , Obermayer-Pietsch Barbara

Background: Polycystic ovary syndrome (PCOS) is a common endocrine condition of unclear origin, characterized by hyperandrogenism (HA), oligo-/amenorrhoea (OM), and polycystic ovarian morphology (PCOM). According to the Rotterdam criteria, PCOS phenotypes A-D range from mild to severe and are defined as phenotype A (HA, OM and PCOM), phenotype B (HA, OM), phenotype C (HA, PCOM) and phenotype D (OM, PCOM). Recent discoveries indicate that microRNAs (miRNAs) play a role in the d...

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ea0099p558 | Reproductive and Developmental Endocrinology | ECE2024

Anti-Müllerian hormone as a predictor of ovarian function in patients undergoing radioiodine treatment for thyroid cancer

Havlinova Barbora , Součkova Ilona , Doležal Jiři

Background: Differentiated thyroid carcinoma is the most common endocrinological malignancy with an increasing incidence over the last 30 years. It is the fifth most common cancer among the young population (1539 years), with women being more frequently affected. Surgical removal of the tumour is the standard treatment method. In indicated cases, total thyroidectomy with subsequent adjuvant radioiodine administration is performed, despite international trends towards les...

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ea0099p559 | Reproductive and Developmental Endocrinology | ECE2024

Assesing the proficiency and alignment of ChatGPT 3.5 responses with guidelines in addressing frequently asked questions by transgender individuals

Tekin Selin , Erturk Banu , Hanife Oguz Seda , Yildiz Bulent

Background: ChatGPT, an advanced language model, employs sophisticated deep learning techniques to generate human-like responses. It stands as one of the most extensive publicly accessible language models. Despite the longstanding application of Artificial Intelligence (AI) in diverse domains, its application in healthcare raises concerns about the reliability of information. It is equally important to assess whether the provided information is supported by dependable referenc...

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ea0099p560 | Reproductive and Developmental Endocrinology | ECE2024

Dampened HPG axis activity and improved reproductive lifespan in dummerstorf superfertile mouse lines

Weitzel Joachim , Carolin Ludwig , Marten Michaelis

Research in the field of reproductive biology is largely based on informative mouse models. Almost all of these mouse models (~99%) exhibit an unfavourable reproductive phenotype - these mouse models are subfertile or infertile in one or possibly both sexes. In contrast, the number of animal models that show an enhanced reproductive phenotype is extremely rare. Nevertheless, these mouse models could be very informative in identifying mechanisms and pathways associated with enh...

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ea0099p561 | Reproductive and Developmental Endocrinology | ECE2024

In vitro analysis of FSHR internalization and signalling mediated by two different FSH preparations

Baschieri Lara , Lazzaretti Clara , Mascolo Elisa , Perri Carmela , Sperduti Samantha , Fusco Claudia , Simoni Manuela , Casarini Livio

Follicle stimulating hormone (FSH) is produced by the anterior pituitary gland and is a key hormone in the reproductive system. FSH is a heterodimeric glycoprotein composed with two extensively glycosylated protein subunits (α and β) N-glycosylated in two positions (Asn52 and Asn78in the FSHα subunit and Asn7 and Asn24 in the FSHβ subunit). Due to different glycosylation pattern, several FSH isoforms may different...

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ea0099p562 | Reproductive and Developmental Endocrinology | ECE2024

Assessment of muscle mass and strength in women with PCOS following oral contraceptive therapy

Aksun Seren , Karacoban Levend , Idilman Ilkay , Yildiz Bulent

Background and Aim: Polycystic ovary syndrome (PCOS) is characterized by androgen excess and ovulatory dysfunction and appears to be associated with alterations in muscle mass and function. Combined oral contraceptives are commonly used for the long-term management of PCOS and their potential impact on muscle mass and strength remains unknown. This study aimed to assess whether oral contraceptive (OC) use along with general lifestyle advice would alter muscle mass and strength...

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ea0099p563 | Reproductive and Developmental Endocrinology | ECE2024

Investigation of circulating androgens’ circadian variations: expanding the knowledge by monitoring phase II metabolites

Ponzetto Federico , Parasiliti Caprino Mirko , Campioni Lorenzo , Marinelli Lorenzo , Settanni Fabio , Nonnato Antonello , Mengozzi Giulio , Giordano Roberta , Ghigo Ezio

Background: Many endogenous steroid hormones are reported to be subjected to distinct circadian rhythms, which are driven by central regulators, hormonal bioavailability and half-life. Recently, the measurement of androgens phase II metabolites has gained interest in the diagnosis and management of different endocrinological pathologies, such as polycystic ovarian syndrome (PCOS), female adrenal hyperandrogenism and hirsutism, prostate cancer, but their circadian patterns have...

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26th European Congress of Endocrinology

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