Endocrine Abstracts

Introduction: Multiple cancers have been described more commonly in patients with diabetes, and some exhibit increased aggressiveness of the tumor as well. This association has been debated with regard to thyroid cancer. With this work, we aim to clarify whether type 2 diabetes (DM2) or autoimmunity-related diabetes (type 1 diabetes+LADA=DM1) could coexist with thyroid cancers more aggressive as compared to those found in unaffected (non-DM) individuals....

Introduction: Thyroid nodules (TN) may display somatic RAS mutations, that, however, lack of diagnostic value. In our experience, somatic RAS mutation evaluation could be useful since it has a very high negative predictive value. In the past, somatic RAS mutation had been associated with a good prognosis in thyroid cancer.Objective: This study aims to evaluate whether somatic RAS mutation may associate with TN differential growth pattern.<p class="ab...

Context: Pathological transcriptomic landscape has been the driver of the Molecular Biology in the recent years. Massive RNA sequencing techniques have been extended from bulk RNAseq, to single cell sequencing (scRNAseq) and spot-based spatial transcriptomics (ST), and sometimes laboratory cannot afford all of them. We tried to answer the question about which would be the best option in thyroid gland using Hashimoto’s thyroiditis (HT) context.Method...

Fc Receptor-like (FCRL) genes play a role in the immune system by encoding proteins that function as receptors on the surface of immune cells. Peripheral blood B cells, which are positive for FCRL3 and FCRL4, are rarely found in healthy individuals. In previous studies overexpression of FCRL4 was observed in patients with Graves’ disease (GD) but without association with thyroid peroxidase (TPOAb) or thyroglobulin (TgAb) antibodies. Nonetheless, the clinical significance ...

Aims: While hormonal assays are commonly used for thyroid function assessment, Doppler sonography provides valuable information on vascularization and blood flow. This study aimed to examine the potential associations between Doppler parameters and clinical characteristics of hypothyroid patients, such as the autoimmune nature of the disease and adequacy of LT4 replacement.Methods: A total of 338 patients with hypothyroidism, primarily caused by autoimmu...