Endocrine Abstracts

An experimental study was designed to test a drug candidate for the treatment of diabetes mellitus in rats with streptozotocin (STZ) diabetes.Diabetes was induced in outbred male rats (280–300 g) by single iv injection of streptozotocin 50 mg/kg. The animals showing hyperglycemia (12–15 mM) 72 hours after injection were randomized to receive daily intragastric doses of distilled water, glibenclamid 8 mg/kg, or polyclonal antibodies to C-termina...

Dietressa is a novel drug for the treatment of obesity containing ultra low doses of antibodies to CB1 receptor. A number of new drugs are now at different stages of development, and cannabinoid receptor type 1 is one of the most challenging targets for obesity treatment. However, there are some safety concerns over CB1 receptor antagonists, especially their psychological adverse effects.The study included two parts: the first one was performed on 33 C57...

Background: Osteoprotegerin (OPG) is a bone-related glycopeptide produced by vascular smooth muscle cells due to arterial damage. OPG is considered as an independent predictor of cardiovascular disease in diabetic populations.The aim of this study was to evaluate the interrelation between circulating OPG and coronary vasculature damage in type 2 diabetes mellitus patients.Methods: One hundred and twenty six subjects with stable dia...

Background: Recent evidence has defined that circulating endothelial progenitor cells (EPCs) might have a pivotal role in the presence of atherosclerosis, chronically diseased vessels or following acute vascular injury. We hypothesized that diabetes mellitus (DM) may be related to worsening of ischemic chronic heart failure thereby suppression of mobilization of bone marrow-derived EPCs.The aim of this study was to evaluate predict value of circulating E...

A decade of study has conclusively shown that the reproductive hormone kisspeptin is a critical regulator of the HPG axis acting in the hypothalamus to control GnRH secretion. More recently, the role of kisspeptin outside the HPG axis has received increasing attention with the emergence of associations between kisspeptin, brain processing and behaviour. In this talk, I will provide evidence from studies in rodents to humans, that collectively demonstrate that kisspeptin can in...

A decade of study has conclusively shown that the reproductive hormone kisspeptin is a critical regulator of the HPG axis acting in the hypothalamus to control GnRH secretion. More recently, the role of kisspeptin outside the HPG axis has received increasing attention with the emergence of associations between kisspeptin, brain processing and behaviour. In this talk, I will provide evidence from studies in rodents to humans, that collectively demonstrate that kisspeptin can in...

We are the first who studied the control and the role of transcription factors in the regulation of reproductive functions. Our presentation represents a short review of original data concerning external (temperature, calories restriction) and internal (hormones, protein kinases, RNA interference) in control of selected transcription factors (p53, NFkB, STAT1, CREB1), as well as their role in control of basic ovarian cell functions (proliferation, apoptosis, secretory activity...

Hypothyroidism in pregnancy is generally considered harmful. However, the definition of hypothyroid during pregnancy remains controversial. Measurements of maternal serum TSH have traditionally been used to define hypothyroidism, with values >2.5 mIU/l generally warranting treatment. However, recent data have suggested that the ‘normal’ reference range for serum TSH in healthy pregnant women varies by region as well as by ethnicity. Importantly, changing the uppe...

Progress in reproductive medicine, assisted reproduction, veterinary medicine and animal production and biotechnology is promoted by discovery and application of the new extra- and intracellular regulators of reproductive functions. This is the review of original data concerning the role of some metabolic hormones (GH, leptin, ghrelin and obestatin), growth factors (IGF1, IGFBPs, EGF and thrombopoietin), intracellular mediators of their action (cyclic nucleotides, protein kina...

The status of the neuroendocrine reproductive axis differs between various stages of development and adulthood, and also differs between the sexes, including earlier onset of sexual maturation in females than males and the ability to generate a preovulatory gonadotropin surge in adult females but not adult males. The reproductive axis is controlled by various hormonal and neural pathways that converge upon forebrain GnRH neurons, and many of the developmental and sex differenc...