ISSN 1470-3947 (print) | ISSN 1479-6848 (online)

Endocrine Abstracts (2017) 50 S7.3 | DOI: 10.1530/endoabs.50.S7.3

Kisspeptin and the control of reproductive behaviour

Alexander Comninos1,2


1Imperial College, London, UK; 2Imperial College Healthcare NHS Trust, London, UK.


A decade of study has conclusively shown that the reproductive hormone kisspeptin is a critical regulator of the HPG axis acting in the hypothalamus to control GnRH secretion. More recently, the role of kisspeptin outside the HPG axis has received increasing attention with the emergence of associations between kisspeptin, brain processing and behaviour. In this talk, I will provide evidence from studies in rodents to humans, that collectively demonstrate that kisspeptin can integrate reproductive and emotional behaviour with the control of the HPG axis. These findings have important clinical implications for the treatment of patients with related conditions.

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