Endocrine Abstracts

Regulators are concerned about the potential for environmental chemicals such as agrochemicals and their metabolites to perturb hormone systems. This has led to recommendations for the testing of potential endocrine disrupting chemicals1. The Steroidogenesis H295R assay is an in vitro cell model used to investigate compound effects on steroid hormone biosynthesis, specifically 17β-estradiol (E2) and testosterone (T). The human H295R adreno-carcinoma ce...

The anti-inflammatory protein, annexin 1 (ANXA1) acts via a formyl peptide receptor (FPR), possibly FPR2, in the neuroendocrine system to mediate feedback effects of glucocorticoids and thereby modulate the HPA responses to immune insults. Here, we explored further the role of ANXA1 and the FPR family in mediating the HPA responses to endotoxin (LPS), focusing on the adrenal cortex.Adult male mice treated with LPS (500 μg/kg, i.p.) showed time-depen...

Andrea Dunaif, Northwestern University, Feinberg School of Medicine, Chicago, United States. AbstractDr Dunaif received her MD from Columbia University College of Physicians and Surgeons, trained in New York and Boston and rose to rank of Associate Professor at the Mount Sinai School of Medicine. Since 1992 Dr Dunaif has held posts at Brigham and Women’s Hospital as Director of Women’s Health and Chief of the...

Introduction: Megestrol acetate (MA) is commonly used to promote weight gain in patients with HIV infection. Adrenal insufficiency (AI) has been reported as an adverse effect of MA but this association is not frequently recognized in clinical practice and only few cases develop symptoms of AI. We describe a case of symptomatic AI precipitated by Graves’ hyperthyroidism in a HIV patient on long-term MA treatment.Case report: A 44-year-old man with HI...

Introduction: Vitamin D insufficiency (D-INSUFF) has been associated with impaired immune response in human inmunodeficiency virus (HIV) patients and a worse prognosis in patients with liver fibrosis. Nevertheless, few studies have explored the influence of D-INSUFF in immunological response and liver parameters in HIV and hepatitis C virus co-infected patients (HIV/HCV) on long term highly active antiretroviral therapy (HAART) with successful immune and virological response. ...

Introduction: Although the importance of disorders in glucose metabolism is well recognized in human immunodeficiency virus (HIV) infected patients; the clinical relevance of prediabetes in this population has been little studied. The aims of this observational study were to determine the prevalence of prediabetes in a cohort of HIV-infected patients on long term highly active antiretroviral therapy (HAART) and to assess whether this condition involves the appearance of partic...

Introduction: Vitamin D deficiency is common among people living with HIV worldwide. There is a lack of studies focusing on prevalence and consequences of low levels of vitamin D in our health care area (south of Spain). The main aim of this study is to know the status of vitamin D and its consequences on parameters related to calcium metabolism in a cohort of patients with HIV infection in our area.Methods/Design: Cross-sectional study encompassing HIV-...

Introduction: Several studies have shown that BMI and visceral adiposity index (VAI) are inversely related to serum 25-hydroxy vitamin D (25OHD) in general population. There is a lack of studies performed in HIV population, whose body fat distribution is altered by lipodystrophy or liver disease. We aimed to analyze the cross-sectional associations of VAI and BMI with the 25OHD concentration and parameters related to calcium-phosphorus metabolism in HIV-infected patients.<...

Introduction: 25-Hydroxyvitamin D (25(OH)D) deficiency is a growing healthcare problem in HIV-infected patients. Evidence suggests that an optimal level of 25(OH)D would avoid secondary hyperparathyroidism but its optimal serum concentration has not been defined in HIV-infection. The aim of our study was to identify the 25(OH)D serum concentration that correlates to i-PTH increase and describe the prevalence of hypovitaminosis D in a cohort of HIV-infected patients.<p clas...

Rationale: Low level of vitamin D can results in secondary hyperparathyroidism (SH) that has been linked to increased cardiovascular risk in general population. However, the spectrum of cardiovascular risk associated with SH in HIV-infected adults remains uncertain. Our main aim was to determine its potential association with different markers of cardiovascular risk in HIV-infected adults.Methods: Cross-sectional study. Clinical data related to obesity, ...