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Endocrine Abstracts (2015) 37 GP11.04 | DOI: 10.1530/endoabs.37.GP.11.04

Hospital SAS Jerez de la Frontera, Jerez de la Frontera, Andalusia, Spain.


Rationale: Low level of vitamin D can results in secondary hyperparathyroidism (SH) that has been linked to increased cardiovascular risk in general population. However, the spectrum of cardiovascular risk associated with SH in HIV-infected adults remains uncertain. Our main aim was to determine its potential association with different markers of cardiovascular risk in HIV-infected adults.

Methods: Cross-sectional study. Clinical data related to obesity, blood pressure, glucose metabolism, lipid profile, toxics use, and renal function were recorded. Hypovitaminosis D was defined by 25-hydroxy vitamin D level <30 ng/ml. SH was defined by parathyroid hormone >65 pg/ml in presence of hypovitaminosis D. Patients were divided into three groups according to status of vitamin D and the presence of SH: A) SH and hypovitaminosis D; B) hypovitaminosis D without SH, and C) vitamin D sufficient.

Results: 104 HIV patients were included. Median vitamin D was 30.6±13.6 ng/ml. Prevalence of hypovitaminosis D and SH were 53.8 and 13.5% respectively. Quantitatively, all parameters related to cardiovascular risk, except fasting glycaemia, were higher among patients of group A, but only levels of total cholesterol, LDL, and triglycerides reached significant difference (P=0.002; 0.004; and 0.01 respectively). Also, prevalence of obesity (BMI ≥30 kg/m2) was higher in patients that developed SH (group A) when compared to groups B and C (28.6% vs 19% vs 2%, respectively; P=0.004). In multivariate analysis, SH was not associated with any cardiovascular risk factor.

Conclusions: Though, HIV-infected patients with SH due to hypovitaminosis D have worse cardiovascular risk profile, we can not conclude that SH is independently associated with major risk factors. Nevertheless, we think these patients require a tighter monitoring of lipid profile, blood pressure, and renal function. Further studies will be useful to clarify the role of SH in determining unfavourable cardiovascular outcomes in HIV population.

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