Endocrine Abstracts

Introduction: Autoimmune polyglandular syndrome type 1 (APS1) – severe disease that is rare in pediatric practice. Clinical sings of APS1 are quite diverse, new components may manifest at any age. Their timely diagnosis is critically important, some symptoms can threaten patient’s life. We present our own clinical observation of the APS1 course in siblings.Case report: A 10-year-old previously healthy boy presented with severe weakness, drowsin...

In recent years, there has been an increase in patients with metabolic syndrome (MS), which is an urgent medical problem. The severity of the clinical manifestations of MS affects the quality of life of patients, while reducing physical and mental health. Obesity leads to anxiety and depressive disorders, neurosis–like conditions, which contributes to a worsening prognosis of the underlying disease.The aim of the work was to assess the level of anx...

The prevalence of MS in different countries is 25–30% and varies depending on the diagnostic criteria used. The severity of the clinical manifestations of MS affects the quality of life (QL) of patients, while the indicators of physical and mental health decrease. The problem of QL of patients suffering from overweight and obesity is relevant and socially significant. Obesity leads to anxiety-depressive disorders, neurosis-like conditions, which contributes to a worsening...

Medical therapy of patients with acromegaly is an important addition to surgical treatment or an alternative to it when it is impossible to use the latter. Long-acting synthetic analogues of somatostatin (octreotide and lanreotide) act on the same subtypes of somatostatin receptors, but the drugs have been shown to differ in efficacy and tolerability.Objective: to achieve complete clinical and laboratory remission in patients with acromegaly, which did n...

Background: Cardiovascular mortality is the leading cause of death in elderly people with diabetes. Traditional cardiovascular risk factors are not principal predictors for cardiovascular events in frail elderly.Aim: This prospective study examined biomarkers associated with cardiovascular mortality in 253 community dwelling elderly aged 65 to 99 years. Patients were divided into four main groups: GROUP A-Patients with type 2 diabetes and history of MACE...

Kisspeptin (metastin, HH13, KiSS-1, KiSS-1 metastasis-suppressor, KiSS-1 metastasis suppressor) is a neuropeptid that is encoded by the KISS1 gene (Messager et al., 2005). Kisspeptin-GPR54 signaling has an significant role in initiating secretion of gonadotropin-releasing hormone at puberty (K. Skorupskaite et al., 2014). Is known that kisspeptin to play a role in tumor suppression (especially in breast tissue), (E.J. M...

Introduction: Many studies have pointed to the importance of chronic inflammation and dyslipidemia in the development of atherosclerosis, but data related to the elderly population are still inconsistent. The aim of the work: To determine the importance of determination of markers of inflammation (C-reactive protein - CRP) and lipid status in elderly (≥65 years), functionally dependent persons.Methods: A prospective study that included 257 patients...

Introduction: Metabolic syndrome (MS) is a common disease with up to 25% of the total adult population and more than 45% of those over 60 years of age. When MS develops a complex of metabolic disorders that contribute to the development of vascular atherosclerotic diseases, such as abdominal obesity, hypertension, insulin resistance, dyslipidemia. Exchange disorders in MS are associated with the development of inflammation in organs and vessels, while the role of neutrophils i...

Introduction: Metabolic syndrome (MS) is a disease that develops in obesity in adult patients with the development of numerous metabolic and vascular disorders. In patients with MS, the risk of developing cardiovascular diseases is increased compared to the general population by 1.78 times as a whole and 2.25 times in women. Currently, the number of overweight children and the development of metabolic complications such as fatty liver, hypertension, and type 2 diabetes are inc...

The defeat of the metabolic syndrome (MS) of young people with the development of severe vascular and diabetic complications determines the relevance of its study for the purpose of early diagnosis. Changes in blood at the preclinical stage of MS are reversible, while the main pathogenetic factors of MS are insulin resistance and dyslipidemia. The aim of the study was to assess the role of biochemical parameters in the pathogenesis of MS.Materials and me...