ISSN 1470-3947 (print) | ISSN 1479-6848 (online)

Endocrine Abstracts (2019) 63 P166 | DOI: 10.1530/endoabs.63.P166

Assessment of the functional activity of neutrophilic granulocytes in patients with metabolic syndrome

Olga Smirnova, Eduard Kasparov & Olga Moskalenko

Research Institute of Medical Problems of the North FIC KSC SB RAS, Krasnoyarsk, Russian Federation.

Introduction: Metabolic syndrome (MS) is a common disease with up to 25% of the total adult population and more than 45% of those over 60 years of age. When MS develops a complex of metabolic disorders that contribute to the development of vascular atherosclerotic diseases, such as abdominal obesity, hypertension, insulin resistance, dyslipidemia. Exchange disorders in MS are associated with the development of inflammation in organs and vessels, while the role of neutrophils in MS cellular reactivity is not fully understood.

Aim: To study the characteristics of neutrophil chemiluminescent activity in patients with MS in dynamics.

Materials and methods: We studied 30 patients with MS and 30 practically healthy individuals. The groups did not differ in age and sex. The intensity of the synthesis of reactive oxygen forms NG was determined by chemiluminescence analysis.

Results: The study of luminol-dependent chemiluminescence showed a significant increase in the intensity of spontaneous and induced luminescence in patients with MS, regardless of the degree of obesity. The area under the spontaneous chemiluminescence curve in patients with MS was significantly increased. In the study of zymosan-induced chemiluminescence, the area under the curve is increased in all groups of patients, while in patients with grade III obesity, the total production of reactive oxygen species is significantly higher than in grades I and II. After undergoing a course of treatment, the chemiluminescent activity of neutrophils in MS patients tended to decrease, not reaching the indicators of the control group.

Conclusion: In patients with MS before treatment, there was an increase in neutrophil chemiluminescent activity regardless of the degree of obesity, and after treatment, there was a tendency to decrease, which indicated the effectiveness of the therapy.

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