Endocrine Abstracts

Several lifestyle modification strategies have been suggested to prevent lifestyle-related diseases. However, the situation may be different for health check participants and outpatients. This study aimed to determine suitable lifestyle modification strategies to prevent diabetes in individuals who participated in a medical health check using retrospective cohort study. Individuals who participated in a medical health check in Fukuyama, Japan every year from 2011–2015 wer...

Diabetes is a huge problem affecting 387 million adults by a global prevalence of (8.3%) which is expected to rise to (10.1%) by 2035. Type 2 diabetes, a growing public health problem, is associated with increased morbidity and mortality.Aim: To evaluate the effects of ginger powder supplementation on glycemic status, lipid profile and beta-cell function in obese Egyptian patients with new-onset type 2 Diabetes Mellitus.Design: A r...

Background: Obesity is a multifactorial chronic disease that leads to a cardio-metabolic disease, with increased incidence of atherosclerosis.Aim: Our aim to evaluate premature atherosclerosis in those patient and the impact of different diet on ameliorating its course.Methodology: 100 obese patients were subjected to Hb A1c, Fasting blood glucose, lipid profile, carotid artery duplex, and Brachial artery flow media dilation divide...

Aims/objectives: The aim of this retrospective audit on MANAGEMENT OF ACUTE CHARCOT ARTHROPATHY was to assess the current practice at King’s Mill hospital against the latest National institute of clinical excellence guidelines.Methods: A retrospective audit of 22 patients with diabetes presented with acute Charcot neuro-arthropathy, between January 2016 and August 2018 to the specialist diabetes foot team at KMH. The data was collected from the hosp...

Background: Diabetes-support services facilities available only in few city hospitals. Especially diabetics in rural India lack comprehensive diabetes care plan. NGO’s play key role in psychosocial-support/Counseling/rehabilitation in remote towns of India. Our Project aimed to formulate policy for trained personals to give better & cost-effective Diabetes-support services.Methods: We mobilized training resources from local primary Health-center...

Objective: To assess the prevalence of complications In a cohort of patients with type 2 diabetes mellitus (T2DM).Material and methods: Prospective cohort study. 465 patients with T2DM who were not followed-up at an endocrinology clinic were included. The follow-up was carried out during 26 weeks. The prevalence of complications was evaluated throughout the study. This study was approved by the Ethics and Clinical Research Committee of the University Hos...

Cellular Ca2+ signals have been proposed to activate signal for hormone secretion. In pancreatic β cell which produce insulin, Ca2+ signals have been known contributing insulin secretion. Prior to conduct this study, we confirmed Calbindin-D9k (CaBP-9k) which responsible for regulation of the distribution of free calcium in the cytoplasm. We confirmed Insulin-secreting β cell express CaBP-9k and assumed that CaBP-9k play a certain role in β...

Diabetes mellitus (DM) is a disease of epidemic proportions. Most of DM patients are classified as type 2 diabetes mellitus (T2DM) that is linked with resistance to insulin action on target tissues. In 2015, 415 million people were living with DM worldwide with the highest prevalence rates recorded in the Oceania and the Middle East and North Africa (MENA) regions. In Jordan, a MENA country, the prevalence of DM has increased from 13% to 17% over a 10-year period (1994–20...

Diabetes and acute hyperglycemia are known to increase stroke volume and disability in stroke patients, and deliver worse outcomes after reperfusion therapies. Chronic glycemic status has recently been linked to stroke functional outcome, but its impact on long term prognosis of stroke has rarely been studied. We conducted a study to investigate the impact of glycosylated hemoglobin (HbA1c) levels on functional outcome 1 year after stroke.Methods: Patien...

Background: Dysmetabolic iron overload syndrome (DIOS) is characterized by elevated ferritin and normal transferrin saturation level. Iron metabolism may be linked to the sympathetic overactity. DIOS is seen in 15–20% of the metabolic syndrome cases.Aim: This study aimed to test the hypothesis linking the increased baseline sympathetic drive to the hypertension seen in dysmetablolic iron overload syndrome in cases of metabolic syndrome.<p class=...

Objective: The purpose of this study was to investigate the incidence of obesity, overweight and Hypertension in children and adolescents aged 10–15 in Ahvaz.Methods: This is a epidemiologic study performed on 176 people aged 10–15 in Ahvaz. In 2009, 300 people underwent weight, height and blood pressure measurements. Five years later, the same people were reassessed for obesity, overweight and hypertension, of whom a total of 176 people agreed...

Polycystic ovary syndrome is a common endocrine disorder in women was associated with lipid disorders with increased risk of cardiovascular disease and obesity are associated. This study aimed to compare the lipid profile and fasting plasma glucose levels, insulin resistance in women with polycystic ovary syndrome is done with the control group.Methods: This case–control study on 153 women with PCOS and 449 healthy control subjects from 4 cities in ...

Background: There are about 50% of people living with undiagnosed diabetes worldwide. Moreover, by the time of diabetes diagnosis, chronic disabling complications are already present.Aim: To assess level of A1c by the time of type 2 diabetes diagnosis.Material and methods: We analyzed results of type 2 diabetes screening in three regions of the Republic of Uzbekistan among 2521 people aged 35 or older without known carbohydrates me...

Background: Metabolic syndrome (MetS) and peripheral endothelial dysfunction (PED) are both independently associated with an increased risk of cardiovascular disease (CVD). PED provides prognostic information beyond that provided by conventional risk factors. However, the association between MetS and PED remains uncertain. We evaluated the association between MetS and PED.Methods: We performed a retrospective analysis of patients who were referred to May...

Objectives: The frequency of Cushing’s disease (CD), ACTH independent Cushing’s syndrome (CS) and autonomous cortisol secretion (ACS) in patients with obesity is not well known and the results of the studies are heterogeneous. Therefore, in the present study, we aimed to assess the frequency of CD, CS, and ACS among patients with obesity.Methods: In this study, 813 consecutive patients [683 female, mean age 46.47±14.23-year-old, mean BMI 3...

Background: Diabetes mellitus or more appropriately type 2 diabetes mellitus (T2DM) is the most heterogeneous form of diabetes which is caused by complex interactions between genetic and environmental factors. Although genome-wide analysis has found several single nucleotide polymorphisms (SNPs) in association with T2DM, their documented role is ambiguous and very few studies have reported about the correlation of particular gene expression with T2DM. In this study, we aimed t...

Introduction: The EMPA-REG OUTCOME is a cardiovascular safety study with empaglifozin that has shown a reduction in cardiovascular mortality and a decrease in hospitalization for heart failure. Our work is based on the analysis of the protocol that recognized five changes, the last, 3 years after the start of the study and which affects the definitions of the elements of the primary composite, and following these modifications, we find that the mortality Cardiovascular was inc...

Background and aims: In 2005, experts from the IDF assigned the risk of developing coronary heart disease in patients with type 1 diabetes mellitus (DM1) at age of 30 and over or patients with DM1 with kidney damage equal to the patients with type 2 diabetes mellitus. The need for a non-invasive preclinical marker for identifying patients with the increased risk of cardiovascular disease is obvious. The assessment of arterial stiffness can play a role of such marker. The aim o...

The aim of the study: Laparoscopic sleeve gastroectomy is now the gold standard for bariatric surgery for the treatment of obesity and metabolic syndrome. Laparoscopic gastroplasty is a relatively innovative procedure that has recently been used throughout the world. The purpose of the study was to assess the perioperative safety and outcome of procedures in 2 years.Materials and methods: Sixty two patients with a body mass index of 35 kg/m2 t...

Introduction: The aim of this study was to investigate the incidence of hypertension and to identify potential risk factors in healthy, non-diabetic recently postmenopausal Greek women with normal renal function.Patients and methods: In this retrospective cohort study, we evaluated 141 recently postmenopausal women at baseline and annually thereafter (follow-up time: 1 to 8 years). Blood samples were obtained and ultrasound evaluations were performed at ...

Acromegaly represents a rare chronic disease mainly caused by GH pituitary adenoma with increased levels of GH and IGF-I. Diabetes mellitus was shown to increase cardiovascular morbidity and mortality in patients with acromegaly. Management of diabetes in acromegaly represents a challenging matter and deserves special considerations due to multiple factors that might be implicated in hyperglycemia including: i) the etiology of diabetes, which could be related to acromegaly per...

Background: Irisin is a new myokin and adipokine related to human obesity and insulin resistance status.Aim: To assess serum irisin level as well as to investigate whether serum irisin is related to glycemic indicators, and micro and macrovascular complications in patients with T2DM.Methods: The study included 60 T2DM patients and 30 healthy controls. Anthropometric measures, neurological assessment and fundus examination were done...

Introduction: The formation of oxidative stress in the biological reaction of inflammation is accompanied by the formation of methylglyoxal (MG), which initiates the glycosylation reaction of proteins. When hyperglycemia MG content significantly increased. MG interacts with the amino groups of lysine and arginine to form further glycation end products (CNG). Glycation is due to the ability of glucose to form irreversible chemical compounds of CNG with amino groups of proteins....

Objectives: Eating disorders often co-occur with diabetes, and this comorbidity is associated with severe medical complications. The DEPS-R is a 16-item diabetes-specific self-report measure of disordered eating that can be completed in <10 min. The purpose of the study was to translate and validate the Russian version of the Diabetes Eating Problem Survey–Revised (DEPS-R).Methods: 372 patients with diabetes mellitus using insulin injections par...

Introduction: Retinol binding protein (RSP) is a member of the adipokine family associated with insulin resistance (IR). With an excess of free fatty acids, the binding of insulin by hepatocyte receptors decreases and hyperinsulinemia develops. RSP is a transport protein for retinol, synthesized in hepatocytes and adipocytes. The level of RSP increased in patients with obesity, diabetes mellitus and non-alcoholic fatty liver disease (NAFLD) correlated positively with the sever...

Introduction: The prison environment is a space that involves certain restrictions on prisoners. The diabetic subject requires, however, special attention. The aim of this work is to evaluate the impact of this medium on the glycemic balance and the metabolic profile.Patients and method: Descriptive cross-sectional study carried out on a health campaign day in a penitentiary center, in the men’s sector, and concerned patients with known diabetes fro...

The aim of investigation to study of optimization of treatment of women of childbearing age with metabolic syndrome.Material and methods: Under supervision were 20 women with a metabolic syndrome who applied for infertility in Center of Endocrinology from 2014–2015. The control group consisted of 20 women without obesity and without disturbances of the menstrual cycle. The age of patients ranged from 20 to 39 years and averaged 28.3±0.64 years....

Introduction: Chronic hepatitis and NAFLD represent a global public health problem since they are two common cause of chronic liver disease. Hepatic steatosis (HS) is becoming highly prevalent worldwide and its association with hepatitis B, although controversial previously, is increasingly encountered and thought to be related to host factors.Aim and methods: The aim of this retrospective study is to determine the prevalence of HS in chronic hepatitis B...

Murine protein serine-threonine kinase 38 (MPK38), also known as maternal embryonic leucine zipper kinase (Melk), is a member of the AMP-activated protein kinase (AMPK)-related kinase family and regulates multiple cellular processes, including cell cycle, stem cell self-renewal, apoptosis, carcinogenesis, and metabolism, and is activated in response to apoptosis signal-regulating kinase 1 (ASK1)/TGF-β/p53 signals. A serine/threonine protein phosphatase PP5 has been sugges...

Background: It is known that rheumatoid arthritis (RA) can be a part of autoimmune polyglandular syndrome and be combined with endocrine diseases.Objectives: To study the effects of autoimmune thyroiditis (AIT) and diabetes mellitus (DM) on the clinical and laboratory manifestations of RA.Methods: The study included two groups of patients. The first group of patients included 24 patients (20 women and 4 men, mean age - 68.37±1...

Background: Acute intermittent porphyria (AIP) is characterized by attacks of abdominal pain and neuropsychiatric symptoms. This disease is more frequently and more severely affecting women. Hem deficiency in the liver of AIP patients stimulates an increase in ALA-synthase which triggers an escalating metabolic chain reaction, leading to an increase in the porphyrin content. Treatment of AIP is carbohydrate-rich diet and by treating the attacks with intravenous infusions of gl...

Purpose: Agouti-related protein (AgRP) is known as an orexigenic neuropeptide which is expressed in the hypothalamic arcuate nucleus. It’s possible AgRP is an important molecule in glucocorticoid (GC) induced obesity (e.g. Cushing syndrome), because GC positively regulate hypothalamic AgRP. To clarify the role of AgRP in GC-induced obesity, we investigate here the effect of GC on AgRP deficient mice.Methods: Male wild-type littermates (n=20...

Pathogenesis of Non-alcoholic fatty liver disease in 90% combined with diabetes mellitus (DM) of the second type. Factors cutting: abdominal obesity, excessive content of free fatty acids. Development of insulin resistance through protein kinase. Violation of the transmission of insulin signal leads to damage to the endothelium. Glycation of nitric oxide synthase leads to the development of diabetic complications and violates the sensitivity of the insulin receptors.<p cla...

Obesity affects on the composition of bile: the lithogenicity of bile increases, biliary sludge and cholelithiasis are developing. Under the influence of the active form of oxygen, abnormal forms of bile acids are formed, which negatively affects the development and progression of the pathological process. With the development of inflammation in the liver and pancreas, disturbances in the membrane proteins of glucose transporters occur, the activity of nuclear receptors for th...

Introduction: Pancreatic islet transplantation is an effective treatment for patients with type 1 diabetes mellitus (T1DM) with unstable metabolic control. However, the quality of islets isolated from a donor is negatively affected by the inflammatory environment related to the donor’s brain death and by the stress related to islet isolation and culture. To overcome islet quality loss, some studies have co-cultured islets with mesenchymal stromal cells (MSCs). Considering...

Background: Lipoprotein (a) (Lp(a)) is a low-density lipoprotein like particle which has proatherogenic and a prothrombotic properties. Therefore, increased Lp(a) levels have been reported to be associated with a higher cardiovascular risk in numerous studies. However, the association between Lp(a) and metabolic disorders such as diabetes or metabolic syndrome (MetS) is still controversial. This study aimed to examine the association between Lp(a) levels and presence of MetS i...

Introduction: Blood groups and the Rh factor are involved in several pathologies. Some studies have also identified them as risk factors for diabetes. The objective of this work is to evaluate the possible association between ABO blood groups, rhesus (Positive, Negative) and the risk of diabetes.Patients and methods: This is a case-control study involving 257 diabetic patients followed in the hygiene department and 266 controls followed at Sidi Othmane H...

Introduction: Obesity is a risk factor for cardiovascular disease and diabetes. The objective of this work is to study the prevalence of obesity among a consultant population at the Hygiene Service of the Sidi-Othman District (ASO) in Casablanca.Patients and methods: This is a case-control study of subjects consulting the Sidi Othmane hygiene service. Socio demographic, anthropometric data (weight, height, waist circumference, hip circumference, body mas...

Introduction: The question of the relationship between vitamin D and cardiovascular disease is still open to debate. Recent, exciting and preliminary evidence suggests that vitamin D may play a role in the occurrence of cardiovascular events.Materials and methods: Patients of both sexes, involving 290 patients recruited between September and March, aged between 40 and 80 years, with type 2 diabetes mellitus after informed consent. We excluded patients wi...

Issues: In resource-poor-settings, Unlike Western nations monitoring DIABETES-treatment Adherence is low priority due to lack of training modules/funds/expertise. we analyzed experiences in using locally available Complementary Alternative Medicines [CAM] in rural/tribal areas.Aims: Facilities for diagnosis/treatment located in major cities & are unaffordable to >85%. ADR’s & social stigma worsened situation. CAM must be incorporated alo...

Background: Cultural/psychological/spiritual/social factors influence quality-of-life (QOL) of population with diabetes [PWD]. We correlated spiritual well-being, religiosity, QOL, depression, and end-of-life despair in terminally ill PWD. We also explored stigmatized-issue of sexual-desire of PWD.Aim: Evaluate spirituality and its relation to depression and the QOL. Analyze impact of anxiety/mental-fatigue due to DIABETIES-diagnosis on sexuality/desire....

Aim: Diabetes and prediabetes become prevalent day by day, likewise their complications are also as important as they are. Lipid profile is also evaluated for cardiovascular diseases which are the major complications of diabetes and prediabetes. Non-HDL cholesterol has begun to be taken as one of the treatment goals, especially in diabetics, with respect to the recent dyslipidemia guidelines. The aim of this study is to compare non-HDL values in women with normal or impaired g...

The proline rich and Gla domain genes PRRG1-4 encode for short transmembrane proteins. PRRG proteins contain a Gla domain with glutamic acid residues which are gamma-carboxylated in a vitamin-K-depend manner. In a previous study, we were able to show a decrease in PRRG1 gene expression during intima thickening in atherosclerosis. In this study, we investigated the association of single nucleotide polymorphisms (SNPs) in the vitamin-K-dependent protein PRRG1 with cardiovascular...

Background and aims: In adipose tissue, excess of energy is stored inside cytosolic lipid droplets as triglycerides. During fasting or exercise, the stored fat is mobilized for utilization as free fatty acids and glycerol via lipolysis. The complete lipolysis of triglycerides is mediated by the orchestrated activation of adipose triglyceride lipase (ATGL) and hormone-sensitive lipase, which have been associated with obesity. There is compelling evidence that the protein compar...

Objectives: 1. To evaluate the effect after two years of bariatric surgery on comorbidities in patients with diabetes mellitus type 2 (DMT2) and obesity grade II or higher.2. Analyze the surgical complications in these patients.Material and methods: Cohort study with intrasubject measures (before-after) in patients with grade II or higher obesity and T2DM, who underwent bariatric surgery (gastric bypass or vertical gastrectomy) at ...

Introduction: Metabolic syndrome (MS) is a common disease with up to 25% of the total adult population and more than 45% of those over 60 years of age. When MS develops a complex of metabolic disorders that contribute to the development of vascular atherosclerotic diseases, such as abdominal obesity, hypertension, insulin resistance, dyslipidemia. Exchange disorders in MS are associated with the development of inflammation in organs and vessels, while the role of neutrophils i...

Objectives: To determine the lifestyle in patients with morbid obesity in a previous group and in a group after performing bariatric surgery.Material and methods: Cross-sectional study in two groups of patients with morbid obesity one before and one after bariatric surgery attended in the Clinical Management Unit of Endocrinology and Nutrition of the Puerta del Mar Hospital in Cádiz. The clinical and analytical data of the patients, the sociodemogra...

Patients with type 1 diabetes (T1DM) and insulin hypersensitivity reaction of any type are at high risk of acute and chronic long term complications of hyperglycaemia and glycaemic variability. Such patients are challenging to manage. We present a case report. A 57 year old lady with T1DM for 21 years managed with insulin pump for 7 years reported new onset intermittent skin reaction at the pump infusion site over the last two years. She described her skin becoming swollen and...

Introduction: Type 2 diabetes has a relationship with fatty liver. Fatty liver can progress to liver fibrosis. This study examined relationship between liver fibrosis and diabetes-related complications in type 2 diabetic patients.Methods: This study analyzed data from the 2007 to 2015 the Korea National Health and Nutrition Examination Survey (KNHANES) in South Korea. Which included values of c-peptide, fasting blood sugar, AST, ALT, and platelet to calc...

Obesity is considered as a major factor of insulin resistance and diabetes mellitus risk. Study on lipid composition of tissues in obesity is relevant in understanding of mechanisms underlying insulin resistance.Aim: The work was initiated to study lipid composition of liver and skeletal muscles tissues in rats with alimentary obesity.Materials and methods: Obesity was induced in rats leading an inactive lifestyle with prolonged hi...

Objectives: The brain plays a major role in controlling the desire to eat. We performed a meta-analysis to assess the association of dopamine transporter (DAT)/dopamine receptor (DR) availabilities from neuroimaging studies with obesity.Methods: We performed a systematic search of MEDLINE and EMBASE for English-language publications. Data were extracted from the publications independently by two reviewers. Effect sizes were correlation coefficient betwee...

Objective: Thyroid dysfunction is frequently associated with functional disturbances of the brain. We performed a meta-analysis of previous positron emission tomography and single-photon emission computed tomography studies using a coordinate-based technique of activation-likelihood estimation (ALE) to investigate the potential background of neuropsychiatric complications in patients with hypo- and hyperthyroidism.Methods: We performed a systematic searc...

Combination of coronary heart disease (CHD) with diabetes mellitus type 2 significantly increases the risk of left ventricular remodeling. The objective of the study was to determine the association of biomarkers of myocardial fibrosis with the level of glycaemia at CHD in patients with and without DM type 2.Methods: We have examined 104 patients with CHD of everage age 64.9±0.3 years old, 27 of them were with DM type 2; 77 patients were without DM ...

Objective: Vitamin D deficiency has been related to extraskeletal manifestations such as insulin resistance, type 2 diabetes mellitus (DM) and obesity. The objective of this study was to assess the prevalence of vitamin D insufficiency and deficiency in a population of patients with prediabetes and with type 2 DM already established, and to see if there were differences according to different parameters.Material and methods: Cross-sectional study, in whi...

Prevention of familial diabetes mellitus is a most urgent problem in diabetology. Genetic susceptibility is a leading factor in diabetes mellitus onset.Aim: The work was initiated to assess potentiality of diabetes mellitus risk prediction based on genealogical analysis.Materials and methods: For the purpose of the study, 53 patients with diabetes mellitus were examined. The probands’ mean age was 14.4 years. Genealogical medi...

Background/Objectives: Although it has been well-established that menopause causes a shift in body fat, thereby eliciting metabolic disturbances in women, there has been no study conducted yet to examine the best obesity parameters to predict the risk of nonalcoholic fatty liver disease (NAFLD) in this population. Thus, the aim of this study was to compare the efficacy of body mass index (BMI), waist circumference (WC), and waist-to-hip ratio (WHR) for screening NAFLD accordin...

Objective: To establish possible associations of the polymorphism of the insulin receptor substrate−1 (IRS-1) gene with the severity of various components of metabolic syndrome in patients with arterial hypertension (AH). We examined 187 patients with AH aged 45–55 years (with history of hypertension less than 5 years, unsystematic administration of antihypertensive drugs and/or failure to achieve target blood pressure (BP) levels when prescribing drug therapy). The...

Introduction: Chronic kidney disease (CKD) is growing problem nowadays. Disorder of mineral metabolism occurs in initialCKD and includes the changes of bone metabolism. Fibroblast growth factor 23 (FGF23) plays an important role in phosphate metabolism. Bearing in mind this physiological role of FGF23, but also it’s role in pathophysiology of mineral and bone metabolism, there is a growing interest in conducting clinical studies in patients affected by CKD. Our aim was to...

Purpose: To determine the frequency of trial of labor after caesarean delivery and the success rate of this trial in women with diabetes as well as in a control population.Materials and methods: This is a retrospective case-control study involving 400 cases: 200 diabetic women compared to 200 non-diabetic women conducted in obstetrics and gynecology department of the university hospital center of Monastir over...

Objectives: Peripheral arterial disease (PAD) is the macrovascular complications of type 2 diabetes mellitus, and type 2 diabetic patients with PAD may have higher incidence of foot amputation and coronary heart disease. We conducted a clinical-based cohort study in northern Taiwan in order to assess PAD in diabetes and its associated risk factors.Methods: This study enrolled type 2 DM patients not older than 65 years old who were seen in diabetes clinic...

Introduction: Gestational diabetes mellitus (GDM) is associated with an increase risk of neonatal and maternal complications. Continuous glucose monitoring (CGM) detects glycemic patterns, which could help predict the development of maternal-fetal complications.Objective: To analyze the different glycemic patterns obtained with CGM and to correlate them with the appearance of maternal-fetal complications in GDM.Methods: Women with ...

Objectives: Leptin is an adipokine responsible for controlling appetite and fat accumulation. The role of leptin in pathophysiology of obesity and diabetes mellitus is an area of active investigation.The aim was to study leptin levels in diabetic and nondiabetic patients with increased body mass index (BMI).Methods: A sample of 246 patients with type 2 diabetic mellitus and 86 age and BMI-matched controls were examined. The mean age of the participants w...

Objectives: Adiponectin is an adipokine that play an important role in glucose metabolism and energy homeostasis. The aim of our study was to evaluate adiponectin levels in type 2 diabetes mellitus patients compared with healthy controls.Methods: A sample of 246 patients with type 2 diabetic mellitus and 86 age and BMI-matched controls were included. The mean duration of diabetes was 9.54 (5–13) years. The mean glucose level was 8.14 (5.56–9.9)...

Introduction: Hydroxymethylglutaric aciduria is a rare metabolic disease that is caused by the deficiency of the enzyme 3-hydroxy-3-methylglutaryl-CoA lyase, which participates in the metabolism of leucine and in the formation of ketone bodies. The symptomatology usually occurs in the first two years of life and consists of nausea, vomiting, diarrhea, hypotoniaanddepressed level of consciousness. Metabolic acidosis occurs during crises as a result of the accumulation of metabo...

Introduction: Type 2 diabetes (T2D) is a heterogeneous disease for which causal mechanisms are incompletely understood and subclassification may improve patient management. In the latest assessment of patients with adult-onset diabetes, Ahlqvist and colleagues (2018) defined five new subgroups: an autoimmune form, two severe forms (insulin-deficient and insulin-resistant diabetes) and two mild forms (obesity and age-related diabetes).Objectives:...

Introduction: People living with human immunodeficiency virus (HIV) are at increased risk of developing metabolic disorders, such as obesity, dyslipidemia, insulin resistance, diabetes and hypertension; which may also be associated with hypercortisolism. Due to the similarity between the metabolic changes present in these two clinical situations, several studies have evaluated whether HIV-infected patients have increased levels of cortisol, but the results are not consensual. ...

Background: Bariatric surgery remains the most effective method of weight loss and can result in partial or complete resolution of multiple obesity-related comorbidities. Bariatric surgery should be performed in conjunction with a comprehensive preoperative assessment and a follow-up plan consisting of nutritional, behavioral, and medical programs. The bariatric surgical procedures are associated with significant long-term complications, primarily malnutrition.<p class="ab...

Purpose: Coronary artery disease (CAD) is more common and severe in diabetic patients. The aim of this study is to assess the frequency of silent myocardial ischemia in asymptomatic diabetitics by myocardial perfusion scintigraphy and to correlate the results with risk fators.Methods: We prospectively studied 50 (25 men and 25 women) diabetic patients asymptomatic and without known history of CAD. The minimum duration of diabetes was 15 years for the typ...

Hemoglobin A1c (HbA1c) is formed from the addition of a glucose residue to the N terminus of the Beta chain of a hemoglobin molecule via a non-enzymatic glycation pathway. Its levels correlate with the ambient plasma glucose concentration. The 120-day life span of red blood cells makes HbA1c a useful tool to approximate the diabetic control of patients over three to four months. It has also been found to be an accurate predictor of the microvascular and macrovascular complicat...

Introduction: A number of studies reported that almost every fifth patient with thalassemia hav e diabetes. Various factors could contribute to inadequate retrograde glycemic control in thalassemia patients co-existed with diabetes. According to published data, HbA1C seems to be an insufficient marker of the quality of diabetes control in thalassemia patients.Case report: We present a male 67 years old type 2 diabetes patient with disease history for 15 ...

There is growing evidence that platelet indices correlate with functional status of platelets and with the risk of cardiovascular events. In this study we aimed to assess clinical correlates of mean platelet volume (MPV) in patients with abdominal obesity from different age groups. We investigated 111 adults with abdominal obesity, not receiving antiplatelet therapy. Abdominal obesity was defined in accordance with IDF criteria (2006). Group 1 included 44 patients aged 26&#150...

Background: Monogenic Diabetes is relatively rare, representing only 1–2% of total diabetes cases; nevertheless, it is often misdiagnosed primarily as Type 1 Diabetes, leading to unnecessary insulin therapy and delayed recognition of affected family members.Methods: Case report.Results: We describe a case of a young patient who presented with hyperglycemia in the absence of ketosis and following genetic testing, he proved to h...

Objective: To Find Prevalence of type 2 diabetes mellitus (DM) in Age, BMI, Symptoms And Comorbidities (Hypertension, Dyslipidimia) in Indian Scenario.Methods and plan: This is retrospective observational multicentric Study carried out in our four (4) centres of DIA CARE, Ahmedabad during September to December 2018, We divided patients with newly-diagnosed DM in BMI, Age,Symptoms, Comorbidities(Hypertension, Dyslipidimia). We studied consecutive patients...

Introduction: Insulin autoimmune syndrome (IAS) is characterized by the development of hypoglycemia due to insulin and insulin autoantibodies (IAA) interaction. The disease has a strong association with certain alleles of HLA gene. In most cases the disease affects predisposed persons who take drugs containing the sulfhydryl groups. The IAA are also noticed in patients with other autoimmune pathology and in patients with multiple myeloma or monoclonal gammopathy. In c...

Background and purpose: The rising incidence of diabetes mellitus in Albania intensifies the need for effective health education for DM risk reduction among pharmacists, nurses and other health care practitioners. As a result, continuing diabetes education is pivotal in improving the performance of these professionals and thus providing better health care services.Objective: Our goal was to develop an e-learning course on the management of Diabetes melli...

Background and aims: Type 1 diabetes mellitus (T1DM) results from a severe autoimmune destruction of pancreatic beta cells, which renders patients insulin-dependent for life. The triggering of autoimmunity against beta cells is caused by a complex interaction between environmental, genetic and epigenetic risk factors. Although significant progress has been made in elucidating the genetic factors associated with T1DM, the non-genetic components have remained poorly understood. ...

Aim: To estimate the efficacy of structured lifestyle modification program on clinical and metabolic status in overweight/obese patients with type 2 diabetes (T2DM).Materials and methods: The program was implemented in 2 centers (Moscow, Kazan) and 130 participants were recruited (100-active group, 30-control group). The patients’ characteristics in active group: mean age was 54.6±10.2 years, diabetes duration 6.6±5.6 years, BMI 34.4±...

Objective: The aim of this study is to evaluate the bone mineral density, hip geometry parameters and bone quality, measured by trabecular bone score (TBS) in patients with type 1 diabetes mellitus (T1DM).Materials and methods: We examined 97 patients with T1DM (28 males, 69 females, age: 31 (24.9−37.7) yrs., duration of DM: 11 (7−19.5) yrs., HbA1c: 8.6 (7.1−10) %, BMI: 23.1 (21.9−25.7) kg/m2). The control group consist...

Aim: To study the morphofunctional state of the myocardium in young people with diabetes mellitus 1 using magnetic resonance imaging (MRI) technology.Material and methods: 38 patients (14 men, 24 women), aged 18–36 years old, with an experience of type 1 diabetes from 5 to 16 years old were underwent contrastive mri of the heart. The exclusion criteria were: pronounced electrolyte disorders in the blood, dysproteinemia, chronic liver and kidney fail...

Introduction: Recently, PCSK9 inhibitors have been approved in our country for familial hypercholesterolemia and for patients with cardiovascular diseases. They are still scarce data in real life patients effects.Objective: Analyse the features of first patients treated with PCSK9 inhibitors in a specific unit of familial dyslipidemia and the effect on lipid profile and other clinical variables.Material and methods: Data from patie...

Context: Anti-programmed cell death-1 (Anti-PD-1) antibodies have revolutionized advanced cancer therapy. Anti-PD1 therapy is responsible for immune-related adverse events, with frequent endocrine manifestations. Acquired generalized lipodystrophy (AGL), is a rare disease, thought to be immune-mediated, characterized by loss of adipose tissue and insulin resistance-associated complications. We describe the first case of AGL induced by immune checkpoint therapy.<p class="ab...

Introduction: Necrotizing external otitis (NEO) is a serious life-threatening infection of the external ear and skull base condition. The precise etiology of this condition is unknown. Diabetes mellitus is well known to be one of the most tightly associated characteristics seen in NEO patients. It is documented that diabetes causes endarteritis and microangiopathy, leading to poor microcirculation and impaired polymorphonuclear cell function.Patients and...

Background: Osteocalcin (Ost) is an osteoblast derived protein locally acting on bone formation. Ost could also have a role in regulation of glucose and fat metabolism. It has been shown that Ost can directly stimulate proliferation of β cells and have effect on secreting insulin, and can act on insulin sensitivity by cytokines. It was not fully investigated in gestational diabetes mellitus. The aim of our study was to investigate osteocalcin in Turkish gestational diabet...

Introduction: False memory, that is, remembering events, prohibitions and recommendations that did not happen. This phenomenon has long been known in forensics as it seems to be much more recognized in everyday life. This also applies to patients who could significantly interfere with communication with the doctor and education opportunities. In the face of surprisingly few papers on this subject regarding diabetes, we would like to present our observation.<p class="abstex...

Background: Glucagon-like peptide-1 (GLP-1) is secreted from L cell at a small intestine and decreases blood glucose by stimulating insulin secretion. Therefore, GLP-1 receptor antagonists (GLP1-RA) is used to treat type 2 diabetes mellitus. In addition to the hypoglycemic effect, GLP-1 has been reported to reduce heart disease and renal dysfunctions. GLP-1 action on the kidneys is a natriuretic effect. Therefore, it may have a renoprotection effect. However, it is unknown whe...

Background: To identify areas of improvement in the management of Type 1 Diabetes Mellitus patients by analysing their clinical data.Methods: Computer records of 333 T1DM patients on follow-up at Tan Tock Seng Hospital from May to October 2017 were reviewed and analysed retrospectively.Results: The average age of diagnosis is 29.75 years-old, and average BMI was 22.59 kg/m2. 18% of patients had concomitant thyroid diseas...

Background: Insulin Lispro 200 units/ml is a concentrated rapid-acting mealtime insulin (MTI) available as a prefilled, disposable pen (IL200) indicated for adults who require >20 units/day of prandial insulin. In comparison with Insulin Lispro 100 unit/ml prefilled pen, IL200 permits the delivery of an insulin dose in half the injection volume [1] and a lower glide force [2]. This study aims to understand physicians’ reasons to prescribe IL200, as well as characteriz...

Introduction: Familial hypercholesterolemia (FH) is a genetic condition associated with elevated cholesterol levels and increased risk of atherosclerotic cardiovascular diseases. Lipid-lowering drugs, i.e. statins, ezetimibe and PCSK9 inhibitors (PCSK9inh) are most often combined for effective treatment of FH. While statins may be continued during pregnancy if deemed necessary, other lipid-lowering drugs lack safety data leaving little pharmacological therapeutic options in pr...

Background and aim: Insulin resistance is associated with type 2 diabetes and obesity but recent studies suggest that it may also be associated with type 1 diabetes (T1D), which may affect glycemic control. Hypoglycemia is a dreaded condition among patients with T1D and may also limit optimal glycemic management. We aimed to investigate insulin sensitivity and metabolic adaptions in healthy control subjects and T1D subjects.Material and methods: <!--SUB:...

Objective: Evaluation of the role of collagen I type turnover in presentation of metabolic syndrome (MS) key components among the Chernobyl nuclear power plant (ChNPP) accident survivors three decades upon.Results: The study involved 100 clean-up workers of the ChNPP accident of the with MS divided into 2 subgroups: 50 patients with acute radiation sickness (ARS) exposed to doses over 1.0 Gy, 50 patients exposed to doses 0.3–0.9 Sv; 37 patients with...

Introduction: Oral glucose tolerance test (OGTT) allows classification of subjects in 3 groups, depending on glycaemia 120 minutes after 75 g glucose ingestion: normal (glycaemia < 1.4 g/L), glucose intolerant (1.4–2 g/L) and diabetic (>2 g/L). Five insulin profiles associated with different incidence rates of diabetes over 10 years of follow-up have also previously been described. Insulin measurement is very sensible to hemolysis and can advantageously be replace...

Background: Microalbuminuria was originally established as a predictor of renal failure in patients with diabetes mellitus and an indipendent risk factor for cardiovascular disease. The aim of our study is to assess the relationship between microalbuminuria and the other risk factors in diabetics and their prevalence.Methods: 120 patients with type 2 diabetes, were hospitalized at the Internal Medicine in the University Hospital Center ‘Mother Teres...

We have interviewed 246 people aged 18–55 years: 126 with DM type 2 with a duration of more than 5 years; 120 – without DM. The median body mass index (BMI) was 28.81 (23.51; 32.65) kg/m2: at DM – 29.12 (24.48; 33.35); without DM – 27.92 (22.85; 31.26). The presence of DM didn’t show any differences in eating behavior (DEBQ questionnaire) in contrast to BMI and gender. The emotiogenic style has become the leading one, the incentive for food ...

Lipodystrophy is a rare disorder characterised by loss of adipose tissue, severe insulin resistance, diabetes, hypertriglyceridemia, hepatic steatosis with hypoleptinemia. Renal complications are also present but end stage renal disease is less frequent in partial lipodystrophy. We report efficacy and pharmacokinetics of metreleptine during hemodialysis in one case of partial lipodystrophy. A caucasian female presented with acute pancreatitis, major hypertriglyceridemia (25 g/...

Introduction: In the geographical area of southern Spain, in the province of Huelva, we have detected prevalent cases of Dunnigan’s partial hereditary lipodystrophy. The genealogy, the suspicion phenotype and the coordination with the Genetics Service and Reference center, have borne fruit, and more and more families are detected in Our Area. The lipodystrophies, in general, are rare diseases that affect the adipose tissue, disappearance of it in different parts of the bo...

Intro: Diabetic Ketoacidosis (DKA) is a medical emergency characterised by hyperglycemia, ketosis and acidosis. If left untreated it can lead to cerebral oedema, acute kidney injury, Adult Respiratory Distress Syndrome andeven death. Euglycaemic DKA (EuDKA) without hyperglycaemia is rare but increasing cases of EuDKAbeing reported in patients taking SGLT2 inhibitors.Case report: A 53 year old, Type 2 Diabetic was admitted for an elective cholecystecomy. ...

Introduction: Ovarian senescence and fluctuating levels of sex hormones is associated with metabolic derangement and central obesity. The aim of this study was to explore the association between serum levels of sex hormones and metabolic health in non-obese postmenopausal women.Patients and methods: This cross-sectional study included a total of 457 non-obese postmenopausal (BMI <30 kg/m2) women, retrieved from the Menopause Clinic of Aret...

Introduction: Single nucleotide polymorphic variants of the methylenetetrahydrofolate reductase (MTHFR) gene have been related with a tendency to gain weight according to recent studies. The aetiology of atypical anorexia nervosa remains under investigation and might be associated with the genetic background. The aim of this study was to evaluate the association between the presence of A1298C or C677T polymorphisms of the MTHFR gene and weight status in a sample of adolescent ...

Background: Higher body weight is associated with greater bone mineral density (BMD). Lean mass (LM) is positively related with bone parameters in adolescence. However, a number of controversial studies have suggested that fat mass (FM) has beneficial effect or has detrimental effect on BMD in adolescence. These contradictory results of FM on bone parameters might be developed by the non-linear relationship in the adolescent population.Objective: We eval...

Before releasing of SGLT-2 inhibitor, triple combination of metformin, DPP-4 inhibitor and TZD except sulfonylurea was commonly used in our center because it could be best option for delaying progression of diabetes by improving both insulin resistance and secretory dysfunction. SGLT-2 inhibitor is commonly used and recommended as initial combination with metformin in most guidelines because of cardiovascular risk and weight reduction, but theoretically add on to above combina...

Aims: The introduction of Western diet has changed the prevalence of overweight and obesity in Korean young population. The aim of this study was to evaluate the obesity status and its effect on β-cell function and insulin resistance in a healthy young population in Korea.Methods: This was a large-scale, community-based study conducted from January 2007 to December 2010. A total of 2,587 subjects (1,066 men and 1,521 women) aged 19–29 years who...

Introduction: Increased B12 deficiency among T2DM patients using metformin has been reported. Holotranscobalamin (HoloTc), the bioactive form of B12, is proposed as a specific and sensitive marker of B12 deficiency. Methods to evaluate vitamin B12 deficiency in these patients remain controversial.Methods: First, we studied the prevalence of vitamin B12 deficiency in a group of 106 T2DM patients treated by Metformin, not supplemented by B12. Antacids were...

Background: There are several markers of renal function such as estimated glomerular filtration rate (GFR) calculated by serum creatinine and cystatin C and urinary albumin-creatinine excretion ratio (ACR). Recently, a few studies showed relationships between markers of renal function and carotid arterty intima-media thickness (IMT), but the results were inconsistent. The aim of this study is to compare serum cystatin C as risk factors for atherosclerosis in Korean type 2 diab...

Introduction: Depression, anxiety and eating disorders appear more frequently in patients with type 2 diabetes and are associated with worse metabolic control and higher risk of developing micro and macrovascular complications. The aim of this study was to determine the prevalence of psychiatric comorbidities in diabetic patients, candidates for therapy with SGLT2 inhibitors (SGLT2i) and to evaluate their clinical profile and degree of metabolic control before beginning the tr...